Výsledky vyhledávání - "Concepcion Rodriguez"

Akademický článek

Therapeutic strategy for spinal muscular atrophy by combining gene supplementation and genome editing

Autor: Fumiyuki Hatanaka, Keiichiro Suzuki, Kensaku Shojima, Jingting Yu, Yuta Takahashi, Akihisa Sakamoto, Javier Prieto, Maxim Shokhirev, Estrella Nuñez Delicado, Concepcion Rodriguez Esteban, Juan Carlos Izpisua Belmonte

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Abstract Defect in the SMN1 gene causes spinal muscular atrophy (SMA), which shows loss of motor neurons, muscle weakness and atrophy. While current treatment strategies, including small molecules or viral vectors, have shown promise in improving mot

Externí odkaz: https://doaj.org/article/10b9828b196546fa8165e5097af9a12a

Zobrazit plný text záznamu

Akademický článek

In vivo rescue of genetic dilated cardiomyopathy by systemic delivery of nexilin

Autor: Yanjiao Shao, Canzhao Liu, Hsin-Kai Liao, Ran Zhang, Baolei Yuan, Hanyan Yang, Ronghui Li, Siting Zhu, Xi Fang, Concepcion Rodriguez Esteban, Ju Chen, Juan Carlos Izpisua Belmonte

Publikováno v: Genome Biology, Vol 25, Iss 1, Pp 1-14 (2024)

Abstract Background Dilated cardiomyopathy (DCM) is one of the most common causes of heart failure. Multiple identified mutations in nexilin (NEXN) have been suggested to be linked with severe DCM. However, the exact association between multiple muta

Externí odkaz: https://doaj.org/article/11999baaed2c4ab9b5d8511020581917

Zobrazit plný text záznamu

Akademický článek

Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

Wiskott-Aldrich syndrome is caused by mutations in WASP, but the underlying mechanisms remain to be explored. Here the authors reveal that WASP deficiency results in aberrant RNA splicing, and that WASP regulates the transcription of splicing factor

Externí odkaz: https://doaj.org/article/42d4032a62a14197874f6f1fa9c583d6

Zobrazit plný text záznamu

Akademický článek

A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body

Autor: Shuhui Sun, Shuai Ma, Yusheng Cai, Si Wang, Jie Ren, Yuanhan Yang, Jiale Ping, Xuebao Wang, Yiyuan Zhang, Haoteng Yan, Wei Li, Concepcion Rodriguez Esteban, Yan Yu, Feifei Liu, Juan Carlos Izpisua Belmonte, Weiqi Zhang, Jing Qu, Guang-Hui Liu

Publikováno v: The Innovation, Vol 4, Iss 1, Pp 100380- (2023)

Exercise benefits the whole organism, yet, how tissues across the body orchestrally respond to exercise remains enigmatic. Here, in young and old mice, with or without exercise, and exposed to infectious injury, we characterized the phenotypic and mo

Externí odkaz: https://doaj.org/article/1b1e2ed4f9a647a8add861fa7719337b

Zobrazit plný text záznamu

Akademický článek

In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche

Autor: Chao Wang, Ruben Rabadan Ros, Paloma Martinez-Redondo, Zaijun Ma, Lei Shi, Yuan Xue, Isabel Guillen-Guillen, Ling Huang, Tomoaki Hishida, Hsin-Kai Liao, Estrella Nuñez Delicado, Concepcion Rodriguez Esteban, Pedro Guillen-Garcia, Pradeep Reddy, Juan Carlos Izpisua Belmonte

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Short term systemic expression of the reprogramming factors Oct-3/4, Sox2, Klf4, c-Myc (OSKM) rejuvenates aging cells and promotes tissue regeneration. Here the authors show that myofiber-specific expression of OSKM accelerates muscle regeneration by

Externí odkaz: https://doaj.org/article/ec46029f8e914da49e6eeddd4f0bc4ed

Zobrazit plný text záznamu

Akademický článek

Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium

Autor: Tomoaki Hishida, Eric Vazquez-Ferrer, Yuriko Hishida-Nozaki, Yuto Takemoto, Fumiyuki Hatanaka, Kei Yoshida, Javier Prieto, Sanjeeb Kumar Sahu, Yuta Takahashi, Pradeep Reddy, David D. O’Keefe, Concepcion Rodriguez Esteban, Paul S. Knoepfler, Estrella Nuñez Delicado, Antoni Castells, Josep M. Campistol, Ryuji Kato, Hiroshi Nakagawa, Juan Carlos Izpisua Belmonte

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

It is widely believed that cellular senescence plays a critical role in both aging and cancer, and that senescence is a fundamental, permanent growth arrest that somatic cells cannot avoid. Here we show that Myc plays an important role in self-renewa

Externí odkaz: https://doaj.org/article/31205045cd044c04b4a97467e784b2c0

Zobrazit plný text záznamu

Akademický článek

Mutations in foregut SOX2+ cells induce efficient proliferation via CXCR2 pathway

Publikováno v: Protein & Cell, Vol 10, Iss 7, Pp 485-495 (2019)

Abstract Identification of the precise molecular pathways involved in oncogene-induced transformation may help us gain a better understanding of tumor initiation and promotion. Here, we demonstrate that SOX2+ foregut epithelial cells are prone to onc

Externí odkaz: https://doaj.org/article/650bfe1468004174b4f346e6bcc81813

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání