Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Concepción González-Bello"'
Autor:
Diana Rodríguez, Emilio Lence, Juan C. Vázquez-Ucha, Alejandro Beceiro, Concepción González-Bello
Publikováno v:
ACS Omega, Vol 9, Iss 24, Pp 26484-26494 (2024)
Externí odkaz:
https://doaj.org/article/0865ee5187ce473b94d52eeebb5f07a6
Autor:
Ángela Rodríguez, María Maneiro, Emilio Lence, José M. Otero, Mark J. van Raaij, Paul Thompson, Alastair R. Hawkins, Concepción González-Bello
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Irreversible inhibition of the enzyme type I dehydroquinase (DHQ1), a promising target for anti-virulence drug development, has been explored by enhancing the electrophilicity of specific positions of the ligand towards covalent lysine modification.
Externí odkaz:
https://doaj.org/article/cd7d202952bc4340a777bcf1a88518ac
Autor:
Isaac Alonso-García, Juan Carlos Vázquez-Ucha, Marta Martínez-Guitián, Cristina Lasarte-Monterrubio, Salud Rodríguez-Pallares, Pablo Camacho-Zamora, Soraya Rumbo-Feal, Pablo Aja-Macaya, Lucía González-Pinto, Michelle Outeda-García, Romina Maceiras, Paula Guijarro-Sánchez, María José Muíño-Andrade, Ana Fernández-González, Marina Oviaño, Concepción González-Bello, Jorge Arca-Suárez, Alejandro Beceiro, Germán Bou
Publikováno v:
Antibiotics, Vol 12, Iss 6, p 999 (2023)
The OXA-10 class D β-lactamase has been reported to contribute to carbapenem resistance in non-fermenting Gram-negative bacilli; however, its contribution to carbapenem resistance in Enterobacterales is unknown. In this work, minimum inhibitory conc
Externí odkaz:
https://doaj.org/article/d295d8a9ebce435da5297ab375a70884
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
β-Lactam antibiotics represent about 70% of all antibacterial agents in clinical use. They are safe and highly effective drugs that have been used for more than 50 years, and, in general, well tolerated by most patients. However, its usefulness has
Externí odkaz:
https://doaj.org/article/48c735e1802e4dd1bf830cfd2e8c396d
Autor:
Juan A. Rubiolo, Emilio Lence, Concepción González-Bello, María Roel, José Gil-Longo, Manuel Campos-Toimil, Eva Ternon, Olivier P. Thomas, Antonio González-Cantalapiedra, Henar López-Alonso, Mercedes R. Vieytes, Luis M. Botana
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Crambescins are guanidine alkaloids from the sponge Crambe crambe. Crambescin C1 (CC) induces metallothionein genes and nitric oxide (NO) is one of the triggers. We studied and compared the in vitro, in vivo, and in silico effects of some crambescine
Externí odkaz:
https://doaj.org/article/1eef203b891b4fab85fd7cc696d7ece3
Autor:
Inmaculada Andreu, Emilio Lence, Concepción González-Bello, Cristobalina Mayorga, M. Consuelo Cuquerella, Ignacio Vayá, Miguel A. Miranda
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Lapatinib (LAP) is an anticancer drug generally used to treat breast and lung cancer. It exhibits hypersensitivity reactions in addition to dermatological adverse effects and photosensitivity. Moreover, LAP binds to serum proteins and is readily biot
Externí odkaz:
https://doaj.org/article/5b73dfb7750d4ad6bf8e22ffbc4f330d
Autor:
Oscar Molins-Molina, Raúl Pérez-Ruiz, Emilio Lence, Concepción González-Bello, Miguel A. Miranda, M. Consuelo Jiménez
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Triflusal is a platelet antiaggregant employed for the treatment and prevention of thromboembolic diseases. After administration, it is biotransformed into its active metabolite, the 2-hydroxy-4-trifluoromethylbenzoic acid (HTB). We present here an i
Externí odkaz:
https://doaj.org/article/5d3748bb3f2346468cdea3ff8f701ab4
Autor:
Cristina Lasarte-Monterrubio, Juan C. Vázquez-Ucha, Maria Maneiro, Jorge Arca-Suárez, Isaac Alonso, Paula Guijarro-Sánchez, John D. Buynak, Germán Bou, Concepción González-Bello, Alejandro Beceiro
Publikováno v:
Antibiotics, Vol 10, Iss 2, p 210 (2021)
Treatment of infections caused by Acinetobacter spp., particularly A. baumannii, is a major clinical problem due to its high rates of antibiotic resistance. New strategies must be developed; therefore, restoration of β-lactam efficacy through the us
Externí odkaz:
https://doaj.org/article/5bf0a613c47c4d0a88f564f7b67ab07c
Autor:
Bou, Isaac Alonso-García, Juan Carlos Vázquez-Ucha, Marta Martínez-Guitián, Cristina Lasarte-Monterrubio, Salud Rodríguez-Pallares, Pablo Camacho-Zamora, Soraya Rumbo-Feal, Pablo Aja-Macaya, Lucía González-Pinto, Michelle Outeda-García, Romina Maceiras, Paula Guijarro-Sánchez, María José Muíño-Andrade, Ana Fernández-González, Marina Oviaño, Concepción González-Bello, Jorge Arca-Suárez, Alejandro Beceiro, Germán
Publikováno v:
Antibiotics; Volume 12; Issue 6; Pages: 999
The OXA-10 class D β-lactamase has been reported to contribute to carbapenem resistance in non-fermenting Gram-negative bacilli; however, its contribution to carbapenem resistance in Enterobacterales is unknown. In this work, minimum inhibitory conc
Autor:
Cristina Lasarte-Monterrubio, Paula Guijarro-Sánchez, Juan Carlos Vázquez-Ucha, Isaac Alonso-Garcia, Laura Alvarez-Fraga, Michelle Outeda, Marta Martinez-Guitian, Andrea Peña-Escolano, Romina Maceiras, Emilio Lence, Concepción González-Bello, Jorge Arca-Suárez, German Bou, Alejandro Beceiro
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
Emergence of cefiderocol resistance among carbapenemase-producing Enterobacterales, particularly those in the Enterobacter cloacae complex (ECC), is becoming of alarming concern; however, the mechanistic basis of this phenomenon remains poorly unders