Výsledky vyhledávání - "Concepción Gómez-Moutón"

Establishment and Maintenance of Cell Polarity During Leukocyte Chemotaxis

Autor: Santos Mañes, Concepción Gómez-Moutón

Publikováno v: Cell Adhesion & Migration. 1:69-76

The term polarity refers to the differential distribution of the macromolecular elements of a cell, resulting in its asymmetry in function, shape and/or content. Polarity is a fundamental property of all metazoan cells in at least some stages, and is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40933d8e72536dd90dc8fb58083e43f3
https://doi.org/10.4161/cam.1.2.4547

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Filamin A interaction with the CXCR4 third intracellular loop regulates endocytosis and signaling of WT and WHIM-like receptors

Autor: Concepción Gómez-Moutón, Sonia Jiménez-Baranda, Fumihiko Nakamura, Rosa M. Peregil, Santos Mañes, Thomas P. Stossel, Thierry Fischer

Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a rare congenital immunodeficiency often caused by mutations in the last 10 to 19 C-terminal amino acids of CXCR4. These mutations impair CXCR4 internalization and increas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816bacbb2925969e760e1f2b4972a8ee
https://europepmc.org/articles/PMC4347305/

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Autor: Concepción Gómez-Moutón, Esther Leonardo, Emilia Mira, Rosa Ana Lacalle, Santos Mañes

Publikováno v: Clinical and Experimental Metastasis. 19:313-318

Tumor cells acquire the ability to enter blood vessels surrounding the primary tumor, endowing them with the capacity to disseminate and become established in distant sites, originating a metastasis. Determination of the intravasation ability of tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8e1de1dcfb7f360887737350b08d8fd
https://doi.org/10.1023/a:1015563031769

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Membrane raft microdomains in chemokine receptor function

Autor: Concepción Gómez-Moutón, Rosa Ana Lacalle, Santos Mañes, Emilia Mira, Gustavo del Real, Carlos Martínez-A

Publikováno v: Seminars in Immunology. 13:147-157

Cell chemotaxis requires the acquisition and maintenance of both spatial and functional asymmetry between initially equivalent cell parts. In leukocytes one becomes the leading edge and the other, the rear edge or uropod. The acquisition of this cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139dc1049f8263fe1b44c48df1c5ba86
https://doi.org/10.1006/smim.2000.0306

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The Matrix Metalloproteinase-9 Regulates the Insulin-like Growth Factor-triggered Autocrine Response in DU-145 Carcinoma Cells

Autor: Concepción Gómez-Moutón, Leonor Kremer, Rosa Ana Lacalle, Mercedes Llorente, Emilia Mira, Carlos Martínez-A, Santos Mañes

Publikováno v: Journal of Biological Chemistry. 274:6935-6945

The androgen-independent human prostate adenocarcinoma cell line DU-145 proliferates in serum-free medium and produces insulin-like growth factors (IGF)-I, IGF-II, and the IGF type-1 receptor (IGF-1R). They also secrete three IGF-binding proteins (IG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa7f565707095b4d1d0c6a6dcd2ec35e
https://doi.org/10.1074/jbc.274.11.6935

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Filamin-A regulates actin-dependent clustering of HIV receptors

Autor: Alfonso Valencia, Antonella Viola, Santos Mañes, Dimiter S. Dimitrov, Lorena Martínez-Prats, Rosa Ana Lacalle, Concepción Gómez-Moutón, Sonia Jiménez-Baranda, Ana M. Rojas, Carlos Martínez-A, Emilia Mira, Rafael Delgado

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Human immunodeficiency virus (HIV)-1 infection requires envelope (Env) glycoprotein gp120-induced clustering of CD4 and coreceptors (CCR5 or CXCR4) on the cell surface; this enables Env gp41 activation and formation of a complex that mediates fusion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4470aad7fb832cf4e285f0cfedf4cb
http://hdl.handle.net/11577/3267492

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T cell costimulation by chemokine receptors

Autor: Barbara Molon, Santos Mañes, Carlos Martínez-A, Antonio Lanzavecchia, Monica Bettella, Concepción Gómez-Moutón, Antonella Viola, Giorgia Gri

Publikováno v: Nature immunology. 6(5)

Signals mediated by chemokine receptors may compete with T cell receptor stop signals and determine the duration of T cell-antigen-presenting cell interactions. Here we show that during T cell stimulation by antigen-presenting cells, T cell chemokine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20984782bff3df63b62612455e7f9cdd
https://pubmed.ncbi.nlm.nih.gov/15843794

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Mastering time and space: immune cell polarization and chemotaxis

Autor: Sonia Jiménez-Baranda, Rosa Ana Lacalle, Concepción Gómez-Moutón, Carlos Martínez-A, Emilia Mira, Santos Mañes

Publikováno v: Seminars in immunology. 17(1)

Many immune cells can detect the direction and intensity of an extracellular chemical gradient, and migrate toward the source of stimulus. This process, called chemotaxis, is essential for immune system function and homeostasis, and its deregulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751bde840692a9c20a73351df7e5313d
https://pubmed.ncbi.nlm.nih.gov/15582490

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