Dalbavancina como tratamiento antibiótico de pacientes con endocarditis y/o bacteriemia por cocos grampositivos, en la práctica clínica habitual

Autor: Carmen Hidalgo-Tenorio, Samantha Elisabeth de Jesus, Concepción Fernández-Roldán, Rosario Javier, Juan Pasquau

Publikováno v: Cirugía Cardiovascular, Vol 25, Iss 1, p 70 (2018)

Externí odkaz: https://doaj.org/article/430949884eee4fcf91aa4f22d65ec604

Efficacy and safety of early treatment with sarilumab in hospitalised adults with COVID-19 presenting cytokine release syndrome (SARICOR STUDY): protocol of a phase II, open-label, randomised, multicentre, controlled clinical trial

Autor: Jesús Rodríguez-Baño, Antonio Luque-Pineda, Julian Torre-Cisneros, M Ángeles Esteban-Moreno, Rafael León López, Sheila Cárcel Fernández, Laura Limia Pérez, Alberto Romero Palacios, María Concepción Fernández-Roldán, Eduardo Aguilar Alonso, Inés Pérez Camacho, Nicolás Merchante, Julián Olalla, Marta Santos

Publikováno v: BMJ Open, Vol 10, Iss 11 (2020)

Introduction About 25% of patients with COVID-19 develop acute respiratory distress syndrome (ARDS) associated with a high release of pro-inflammatory cytokines such as interleukin-6 (IL-6). The aim of the SARICOR study is to demonstrate that early a

Externí odkaz: https://doaj.org/article/163f0988921e4d2b87b1245e7cc548b1

Role of IP-10 to Predict Clinical Progression and Response to IL-6 Blockade With Sarilumab in Early COVID-19 Pneumonia. A Subanalysis of the SARICOR Clinical Trial

Autor: Marta Trigo-Rodríguez, Sheila Cárcel, Ana Navas, Reinaldo Espíndola-Gómez, José Carlos Garrido-Gracia, María Ángeles Esteban Moreno, Rafael León-López, Pedro María Martínez Pérez-Crespo, Eduardo Aguilar Alonso, David Vinuesa, Alberto Romero-Palacios, Inés Pérez-Camacho, Belén Gutiérrez-Gutiérrez, Francisco Javier Martínez-Marcos, Concepción Fernández-Roldán, Eva León, Alexandra Aceituno Caño, Juan E Corzo-Delgado, Elena Perez-Nadales, Cristina Riazzo, Carmen de la Fuente, Aurora Jurado, Julián Torre-Cisneros, Nicolás Merchante

Publikováno v: Open Forum Infectious Diseases. 10

Background The Clinical Trial of Sarilumab in Adults With COVID-19 (SARICOR) showed that patients with coronavirus disease 2019 (COVID-19) pneumonia and increased levels of interleukin (IL)-6 might benefit from blockade of the IL-6 pathway. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::632a1f67efef716ccdcfcaca5b0445dc
https://doi.org/10.1093/ofid/ofad133

Early Use of Sarilumab in Patients Hospitalized with COVID-19 Pneumonia and Features of Systemic Inflammation: the SARICOR Randomized Clinical Trial

Autor: Nicolás Merchante, Sheila Cárcel, José Carlos Garrido-Gracia, Marta Trigo-Rodríguez, María Ángeles Esteban Moreno, Rafael León-López, Reinaldo Espíndola-Gómez, Eduardo Aguilar Alonso, David Vinuesa García, Alberto Romero-Palacios, Inés Pérez-Camacho, Belén Gutiérrez-Gutiérrez, Francisco Javier Martínez-Marcos, Concepción Fernández-Roldán, Pedro María Martínez Pérez-Crespo, Alexandra Aceituno Caño, Eva León, Juan E. Corzo, Carmen de la Fuente, Julián Torre-Cisneros

Publikováno v: Antimicrobial Agents and Chemotherapy. 66

The objective of this study was to investigate the efficacy and safety of early treatment with sarilumab, added to standard of care (SOC), in hospitalized adults with COVID-19. Methods included phase II, open-label, randomized, controlled clinical tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501628048cffdba82360ad6d06db7b1b
https://doi.org/10.1128/aac.02107-21

Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases

Autor: Isabel Almeida, Divi Cornec, Torsten Witte, Tania F. Rowley, Tianlu Li, Elena Carnero-Montoro, Mariana Brandão, Antonio Garcia-Gomez, Nancy Azevedo, Esmeralda Neves, Ana Lisa Taylor Tavares, Ana Campar, Jacques-Olivier Pers, Nicolas Hunzelmann, Ellen De Langhe, Ernst R. Dow, Magdolna Deák, Jorge Kageyama, Francisco Javier Garrancho, Gerard Espinosa, Carlo Chizzolini, Laleh Khodadadi, Falk Hiepe, Maria Angeles Aguirre-Zamorano, Marta E. Alarcón-Riquelme, Rosario Lopez-Pedrera, Anne Buttgereit, Ricard Cervera, Javier Rodríguez-Ubreva, Fernanda Genre, Jerome Wojcik, Begoña Ubilla Garcia, Héctor Navarro-Linares, Maria Orietta Borghi, N.T. Baerlecken, Katja Kniesch, Yolanda Jiménez Gómez, Zuzanna Makowska, Martin Kerick, Elena Trombetta, Pierre-Emmanuel Jouve, Lorenzo Beretta, Ricardo Blanco Alonso, Bénédicte Rouvière, Isabel Díaz Quintero, Michael Zauner, Ralf Lesche, Daniel Toro-Domínguez, Manuel Rodriguez Maresca, Attila Balog, Pier Luigi Meroni, Qingyu Cheng, Georg Stummvoll, Johan Frostegård, Javier Martín, Márta Bocskai, Joerg Mueller, Tommaso Schioppo, Chris Chamberlain, Sonja Dulic, László Kovács, Raquel López Mejías, Velia Gerl, Francesc Català-Moll, Robert J. Benschop, Sara Remuzgo, Carolina Artusi, María Teruel, Eduardo Collantes-Estevez, Miguel A. González-Gay, Silvia Thiel, Bernard Lauwerys, Maria Gerosa, Yves Renaudineau, Pedro Carmona-Sáez, Raquel Faria, Rocío Aguilar-Quesada, Sepideh Babaei, Nuria Barbarroja, Maria Hernandez-Fuentes, María Concepción Fernández Roldán, Sambasiva P. Rao, Aurélie De Groof, Montserrat Alvarez, Anne-Lise Maudoux, Sikander Hayat, Guillermo Barturen, Maria Juarez, Damiana Álvarez-Errico, Alfonso Corrales Martínez, Julie Ducreux, Lucas Le Lann, Norberto Ortego, Jacqueline Marovac, Sandrine Jousse-Joulin, Enrique Raya, Laurence Laigle, Concepción Marañón, Esteban Ballestar, Manuel Martínez-Bueno, Barbara Vigone, Rik Lories, Doreen Belz, Gabriella Kádár, Gaia Montanelli, Fátima Farinha, Divya Thiagaran, M.C. Castro-Villegas, Christophe Jamin, Alain Saraux, Carlos Vasconcelos, Emanuele de Rinaldis, Donatienne Wynar, Enrique de Ramón, Antonio López-Berrio, Tania Anjos, Alejandro Escudero-Contreras, Ian White, Valérie Devauchelle-Pensec, Ignasi Rodríguez-Pintó, Nieves Varela, Quentin Simon, Michaela Lehner, Inmaculada Jiménez Moleón, Aleksandra Maria Dufour, Rafaela Ortega-Castro, Marialbert Acosta-Herrera, Mcdonald Fiona Mcdougall, Yiannis Ioannou, Jonathan Cremer, António Marinho, Jordi Martorell-Marugán

Publikováno v: Arthritis and Rheumatism
Arthritis and Rheumatism, Wiley, 2020, ⟨10.1002/art.41610⟩
Arthritis and Rheumatism, 2020, ⟨10.1002/art.41610⟩
Arthritis & rheumatology, Vol. 73, no.6, p. 1073-1085 (2021)

OBJECTIVE: Clinical heterogeneity, a hallmark of systemic autoimmune diseases, impedes early diagnosis and effective treatment, issues that may be addressed if patients could be classified into groups defined by molecular pattern. This study was unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1563952d4b64a5f243c20fd857065753
https://hdl.handle.net/10668/17043