Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Conan K. Wang"'
Autor:
Marie Morin, Mathias Jönsson, Conan K. Wang, David J. Craik, Sandie M. Degnan, Bernard M. Degnan
Publikováno v:
PLoS Biology, Vol 22, Iss 5 (2024)
Externí odkaz:
https://doaj.org/article/1902b4ea26344836a283417aba2ab393
Autor:
Mathias Jönsson, Marie Morin, Conan K. Wang, David J. Craik, Sandie M. Degnan, Bernard M. Degnan
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Many echinoderms form seasonal aggregations prior to spawning. In some fecund species, a spawning event can lead to population outbreaks with detrimental ecosystem impacts. For instance, outbreaks of crown-of-thorns starfish (COTS
Externí odkaz:
https://doaj.org/article/f15eb17f0e24436da6c2ee3f3bc8c0f1
Autor:
Yen-Hua Huang, Qingdan Du, Zhihao Jiang, Gordon J. King, Brett M. Collins, Conan K. Wang, David J. Craik
Publikováno v:
Molecules, Vol 26, Iss 18, p 5554 (2021)
Cyclotides have attracted great interest as drug design scaffolds because of their unique cyclic cystine knotted topology. They are classified into three subfamilies, among which the bracelet subfamily represents the majority and comprises the most b
Externí odkaz:
https://doaj.org/article/bf931ce588d9487d96c58271bccceb1f
Autor:
Sixin Tian, Thomas Durek, Conan K. Wang, Christina N. Zdenek, Bryan G. Fry, David J. Craik, Simon J. de Veer
Publikováno v:
Journal of Medicinal Chemistry. 65:15698-15709
Factor XIIa (FXIIa) is a promising target for developing new drugs that prevent thrombosis without causing bleeding complications. A native cyclotide (MCoTI-II) is gaining interest for engineering FXIIa-targeted anticoagulants as this peptide inhibit
Autor:
Yuhui Zhang, Li Wang, Benjamin J. Tombling, Carmen Lammi, Yen-Hua Huang, Yue Li, Martina Bartolomei, Bin Hong, David J. Craik, Conan K. Wang
Publikováno v:
Journal of the American Chemical Society. 144:19485-19498
Optimization of peptide stability is essential for the development of peptides as bona fide alternatives to approved monoclonal antibodies. This is clearly the case for the many peptides reported to antagonize proprotein convertase subtilisin-like/ke
Autor:
Marie Morin, Mathias Jönsson, Conan K. Wang, David J. Craik, Sandie M. Degnan, Bernard M. Degnan
Publikováno v:
Molecular Ecology.
Autor:
Zhian Chen, Yanfang Cui, Yin Yao, Bo Liu, Joseph Yunis, Xin Gao, Naiqi Wang, Pablo F. Cañete, Zewen Kelvin Tuong, Hongjian Sun, Hao Wang, Siling Yang, Runli Wang, Yew Ann Leong, David Simon Davis, Jiahuan Qin, Kaili Liang, Jun Deng, Conan K. Wang, Yen-Hua Huang, Jonathan A. Roco, Sam Nettelfield, Huaming Zhu, Huajun Xu, Zhijia Yu, David Craik, Zheng Liu, Hai Qi, Christopher Parish, Di Yu
Publikováno v:
Science Immunology. 8
In antibody responses, mutated germinal center B (B GC ) cells are positively selected for reentry or differentiation. As the products from GCs, memory B cells and antibody-secreting cells (ASCs) support high-affinity and long-lasting immunity. Posit
Autor:
Yen-Hua Huang, Brett M. Collins, Huawu Yin, Conan K. Wang, David J. Craik, Yanfeng Gao, Gordon J. King, Xiuman Zhou
Publikováno v:
Journal of the American Chemical Society. 143:18536-18547
Peptides have potential to be developed into immune checkpoint inhibitors, but the target interfaces are difficult to inhibit. Here, we explored an approach to mimic the binding surface of PD-1 to design inhibitors. Mimicking native PD-1 resulted in
Publikováno v:
Atherosclerosis. 330:52-60
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a clinically validated target for treating cardiovascular disease (CVD) due to its involvement in cholesterol metabolism. Although approved monoclonal antibodies (alirocumab and evolocumab) tha
Autor:
Marie Morin, Mathias Jönsson, Conan K. Wang, David J. Craik, Sandie M. Degnan, Bernard M. Degnan
Marine animals in the wild are often difficult to access, so that biologists have to extrapolate from the study of animals in captivity. However, the implicit assumption that physiological and cellular processes of animals in artificial environments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2f69970ea1bd6a5fa92e631e9bb5dd2
https://doi.org/10.1101/2022.07.21.501052
https://doi.org/10.1101/2022.07.21.501052