Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Con, Dogovski"'
Autor:
Stanley C. Xie, Yinuo Wang, Craig J. Morton, Riley D. Metcalfe, Con Dogovski, Charisse Flerida A. Pasaje, Elyse Dunn, Madeline R. Luth, Krittikorn Kumpornsin, Eva S. Istvan, Joon Sung Park, Kate J. Fairhurst, Nutpakal Ketprasit, Tomas Yeo, Okan Yildirim, Mathamsanqa N. Bhebhe, Dana M. Klug, Peter J. Rutledge, Luiz C. Godoy, Sumanta Dey, Mariana Laureano De Souza, Jair L. Siqueira-Neto, Yawei Du, Tanya Puhalovich, Mona Amini, Gerry Shami, Duangkamon Loesbanluechai, Shuai Nie, Nicholas Williamson, Gouranga P. Jana, Bikash C. Maity, Patrick Thomson, Thomas Foley, Derek S. Tan, Jacquin C. Niles, Byung Woo Han, Daniel E. Goldberg, Jeremy Burrows, David A. Fidock, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael D. W. Griffin, Matthew H. Todd, Leann Tilley
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a ne
Externí odkaz:
https://doaj.org/article/74ceb3d2587846d1a75544faccf7d8f1
Autor:
Jessica L. Bridgford, Stanley C. Xie, Simon A. Cobbold, Charisse Flerida A. Pasaje, Susann Herrmann, Tuo Yang, David L. Gillett, Lawrence R. Dick, Stuart A. Ralph, Con Dogovski, Natalie J. Spillman, Leann Tilley
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Artemisinin (ART) is a widely used antimalarial drug, but its mechanism of action is poorly understood. Here, Bridgford et al. show that ART kills parasites by a two-pronged mechanism, causing protein damage and compromising proteasome function, and
Externí odkaz:
https://doaj.org/article/65e9ecff6a5e4bf9bde0b3289d249518
Autor:
Michelle Cummins, Con Dogovski, Remy Robert, Malcolm Alderton, Damien Chong, David Proll, Luisa Pontes-Braz, Anna Raicevic, Meghan Hattarki, Stewart Nuttall, Olan Dolezal
Publikováno v:
Antibodies, Vol 3, Iss 2, Pp 215-231 (2014)
Ricin is a potent glycoprotein toxin that is structurally composed of two subunits joined via a disulfide bond: a ~30 kDa subunit A (RTA) and a ~32 kDa subunit B (RTB). There are fears of ricin being used as a weapon for warfare and terrorism and, as
Externí odkaz:
https://doaj.org/article/9ceb17fb645d4b9bb1c7cdedfbe0b062
Autor:
Yawei Du, Carlo Giannangelo, Wei He, Gerald J. Shami, Wenya Zhou, Tuo Yang, Darren J. Creek, Con Dogovski, Xinsong Li, Leann Tilley
Publikováno v:
Antimicrob Agents Chemother
Current best practice for the treatment of malaria relies on short half-life artemisinins that are failing against emerging Kelch 13 mutant parasite strains. Here, we introduce a liposome-like self-assembly of a dimeric artesunate glycerophosphocholi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07531b608765d259bd5c7458b4e41f5e
https://doi.org/10.1128/aac.02065-21
https://doi.org/10.1128/aac.02065-21
Autor:
Stewart Nuttall, Matthew A. Perugini, Iveth González, Joanne L. Casey, Abdulmonem Sanalla, Miles Barraclough, Con Dogovski, Julie Angerosa, Kathy Parisi, Olan Dolezal, Katherine Griffiths, Michael Foley
Publikováno v:
Antibodies, Vol 2, Iss 1, Pp 66-81 (2013)
The single variable new antigen receptor domain antibody fragments (VNARs) derived from shark immunoglobulin new antigen receptor antibodies (IgNARs) represent some of the smallest known immunoglobulin-based protein scaffolds. As single domains, they
Externí odkaz:
https://doaj.org/article/458c969cfbb34fab84dcab36bb4e534e
Autor:
Patrick F. James, Con Dogovski, Renwick C.J. Dobson, Michael F. Bailey, Kenneth N. Goldie, John A. Karas, Denis B. Scanlon, Richard A.J. O’Hair, Matthew A. Perugini
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 7, Pp 1384-1394 (2009)
Human apolipoprotein C-I (apoC-I) is an exchangeable apolipoprotein that binds to lipoprotein particles in vivo. In this study, we employed a LC-MS/MS assay to demonstrate that residues 38–51 of apoC-I are significantly protected from proteolysis i
Externí odkaz:
https://doaj.org/article/89e66b82093245dc8c5ecf64eee803c2
Autor:
Con Dogovski, Stanley C Xie, Gaetan Burgio, Jess Bridgford, Sachel Mok, James M McCaw, Kesinee Chotivanich, Shannon Kenny, Nina Gnädig, Judith Straimer, Zbynek Bozdech, David A Fidock, Julie A Simpson, Arjen M Dondorp, Simon Foote, Nectarios Klonis, Leann Tilley
Publikováno v:
PLoS Biology, Vol 13, Iss 4, p e1002132 (2015)
Successful control of falciparum malaria depends greatly on treatment with artemisinin combination therapies. Thus, reports that resistance to artemisinins (ARTs) has emerged, and that the prevalence of this resistance is increasing, are alarming. AR
Externí odkaz:
https://doaj.org/article/b0443abb5c3b4803bfc017d66cf718e2
Autor:
Stanley C, Xie, Riley D, Metcalfe, Hirotake, Mizutani, Tanya, Puhalovich, Eric, Hanssen, Craig J, Morton, Yawei, Du, Con, Dogovski, Shih-Chung, Huang, Jeffrey, Ciavarri, Paul, Hales, Robert J, Griffin, Lawrence H, Cohen, Bei-Ching, Chuang, Sergio, Wittlin, Ioanna, Deni, Tomas, Yeo, Kurt E, Ward, Daniel C, Barry, Boyin, Liu, David L, Gillett, Benigno F, Crespo-Fernandez, Sabine, Ottilie, Nimisha, Mittal, Alisje, Churchyard, Daniel, Ferguson, Anna Caroline C, Aguiar, Rafael V C, Guido, Jake, Baum, Kirsten K, Hanson, Elizabeth A, Winzeler, Francisco-Javier, Gamo, David A, Fidock, Delphine, Baud, Michael W, Parker, Stephen, Brand, Lawrence R, Dick, Michael D W, Griffin, Alexandra E, Gould, Leann, Tilley
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Here, we describe inhibitors of the Plasmodium proteasome, an enzymatic complex that malaria parasites rely on to degrade proteins. Starting from inhibitors developed to treat cancer, derivatives were designed and synthesized with the ai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a17d17dad9983ee3c287198b34e727b8
https://pubmed.ncbi.nlm.nih.gov/34548400
https://pubmed.ncbi.nlm.nih.gov/34548400
Autor:
Benigno F. Crespo-Fernandez, Eric Hanssen, Elizabeth A. Winzeler, Ioanna Deni, Lawrence Cohen, Du Yawei, Daniel C. Barry, Leann Tilley, Riley D. Metcalfe, David L. Gillett, Kurt E. Ward, Bei-Ching Chuang, Hirotake Mizutani, Lawrence R. Dick, Anna Caroline Campos Aguiar, David A. Fidock, Kirsten K. Hanson, Boyin Liu, Alexandra E. Gould, Stanley C. Xie, Rafael Victorio Carvalho Guido, Francisco-Javier Gamo, Tanya Puhalovich, Shih-Chung Huang, Daniel Ferguson, Paul Hales, Con Dogovski, Sabine Ottilie, Nimisha Mittal, Craig J. Morton, Sergio Wittlin, Robert J. Griffin, Delphine Baud, Tomas Yeo, Michael D. W. Griffin, Jake Baum, Stephen Brand, Alisje Churchyard, Jeffrey Ciavarri, Michael W. Parker
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
The Plasmodium falciparum proteasome is a potential antimalarial drug target. We have identified a series of amino-amide boronates that are potent and specific inhibitors of the P. falciparum 20S proteasome (Pf20S) beta5 active site and that exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1732262eee41ce63468baae5797862
Autor:
Con Dogovski, Michael A Gorman, Natalia E Ketaren, Judy Praszkier, Leanne M Zammit, Haydyn D Mertens, Gary Bryant, Ji Yang, Michael D W Griffin, F Grant Pearce, Juliet A Gerrard, Geoffrey B Jameson, Michael W Parker, Roy M Robins-Browne, Matthew A Perugini
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83419 (2013)
Given the rise in drug-resistant Streptococcus pneumoniae, there is an urgent need to discover new antimicrobials targeting this pathogen and an equally urgent need to characterize new drug targets. A promising antibiotic target is dihydrodipicolinat
Externí odkaz:
https://doaj.org/article/576bb07699574f23beff6f14ff20f259