Výsledky vyhledávání - "Computer Science/Numerical Analysis and Theoretical Computing"

QAPgrid: A Two Level QAP-Based Approach for Large-Scale Data Analysis and Visualization

Autor: Pablo Moscato, Regina Berretta, Mario Inostroza-Ponta

Publikováno v: PLoS ONE
PLoS ONE, Vol 6, Iss 1, p e14468 (2011)

Background The visualization of large volumes of data is a computationally challenging task that often promises rewarding new insights. There is great potential in the application of new algorithms and models from combinatorial optimisation. Datasets

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da1a6b83cb3faa3127a3c84bd805538
http://europepmc.org/articles/PMC3022583

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Hierarchical Clustering Using the Arithmetic-Harmonic Cut: Complexity and Experiments

Autor: Romeo Rizzi, Luke Mathieson, Pritha Mahata, Pablo Moscato

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 12, p e14067 (2010)

Clustering, particularly hierarchical clustering, is an important method for understanding and analysing data across a wide variety of knowledge domains with notable utility in systems where the data can be classified in an evolutionary context. This

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Emergent Properties of Tumor Microenvironment in a Real-Life Model of Multicell Tumor Spheroids

Autor: Roberto Chignola, Edoardo Milotti

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 11, p e13942 (2010)

Multicellular tumor spheroids are an important {\it in vitro} model of the pre-vascular phase of solid tumors, for sizes well below the diagnostic limit: therefore a biophysical model of spheroids has the ability to shed light on the internal working

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http://europepmc.org/articles/PMC2994713

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Quantification of three-dimensional cell-mediated collagen remodeling using graph theory

Autor: Cemal Cagatay Bilgin, Bülent Yener, Amanda W. Lund, Ali Can, George E. Plopper

Publikováno v: PLoS ONE, Vol 5, Iss 9 (2010)
PLoS ONE

Background: Cell cooperation is a critical event during tissue development. We present the first precise metrics to quantify the interaction between mesenchymal stem cells (MSCs) and extra cellular matrix (ECM). In particular, we describe cooperative

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http://europepmc.org/articles/PMC2948014?pdf=render

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Genetic Variants and Their Interactions in the Prediction of Increased Pre-Clinical Carotid Atherosclerosis: The Cardiovascular Risk in Young Finns Study

Autor: Riikka Rontu, Mikko Hurme, Leo-Pekka Lyytikäinen, Nina Mononen, Mika Kähönen, Markus Juonala, Olli T. Raitakari, Leena Taittonen, Terho Lehtimäki, Yue-Mei Fan, Tomi Laitinen, Carita Eklund, Sebastian Okser, Nina Hutri-Kähönen, Tero Aittokallio, Laura L. Elo, Nina Peltonen, Jorma Viikari, Jussi Hernesniemi

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 6, Iss 9, p e1001146 (2010)

The relative contribution of genetic risk factors to the progression of subclinical atherosclerosis is poorly understood. It is likely that multiple variants are implicated in the development of atherosclerosis, but the subtle genotypic and phenotypi

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http://europepmc.org/articles/PMC2947986

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A kernelisation approach for multiple d-hitting set and its application in optimal multi-drug therapeutic combinations

Autor: Elena Prieto, Pablo Moscato, Drew Mellor, Luke Mathieson

Publikováno v: PLoS ONE, Vol 5, Iss 10, p e13055 (2010)
PLoS ONE

Therapies consisting of a combination of agents are an attractive proposition, especially in the context of diseases such as cancer, which can manifest with a variety of tumor types in a single case. However uncovering usable drug combinations is exp

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https://hdl.handle.net/10453/122168

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Random texts do not exhibit the real Zipf's law-like rank distribution

Autor: Ramon Ferrer-i-Cancho, Brita Elvevåg

Publikováno v: PLoS ONE, Vol 5, Iss 3, p e9411 (2010)
PLoS ONE
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Recercat. Dipósit de la Recerca de Catalunya
instname

Background: Zipf's law states that the relationship between the frequency of a word in a text and its rank (the most frequent word has rank , the 2nd most frequent word has rank ,…) is approximately linear when plotted on a double logarithmic scale

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https://hdl.handle.net/2117/175991

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Non-Linear Neuronal Responses as an Emergent Property of Afferent Networks: A Case Study of the Locust Lobula Giant Movement Detector

Autor: Paul F. M. J. Verschure, Sergi Bermúdez i Badia, Ulysses Bernardet

Publikováno v: PLoS Computational Biology
PLoS Computational Biology, Vol 6, Iss 3, p e1000701 (2010)

In principle it appears advantageous for single neurons to perform non-linear operations. Indeed it has been reported that some neurons show signatures of such operations in their electrophysiological response. A particular case in point is the Lobul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea91cac863278dd4e43054a2da59bf7
http://europepmc.org/articles/PMC2837398

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Temperature control of fimbriation circuit switch in uropathogenic Escherichia coli: quantitative analysis via automated model abstraction

Autor: Hiroyuki Kuwahara, Michael S. Samoilov, Chris J. Myers

Publikováno v: PLoS Computational Biology, Vol 6, Iss 3, p e1000723 (2010)
PLoS Computational Biology

Uropathogenic Escherichia coli (UPEC) represent the predominant cause of urinary tract infections (UTIs). A key UPEC molecular virulence mechanism is type 1 fimbriae, whose expression is controlled by the orientation of an invertible chromosomal DNA

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http://europepmc.org/articles/PMC2845655?pdf=render

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Spatial and topological organization of DNA chains induced by gene co-localization

Autor: François Képès, Ivan Junier, Olivier C. Martin

Publikováno v: PLoS Computational Biology
PLoS Computational Biology, Public Library of Science, 2010, 6 (2), pp.1000678
PLoS Computational Biology, Public Library of Science, 2010, 6 (2), pp.1000678. ⟨10.1371/journal.pcbi.1000678⟩
PLoS Computational Biology, Vol 6, Iss 2, p e1000678 (2010)
Plos Computational Biology 2 (6), 1000678. (2010)
PLoS Computational Biology, 2010, 6 (2), pp.1000678. ⟨10.1371/journal.pcbi.1000678⟩

Transcriptional activity has been shown to relate to the organization of chromosomes in the eukaryotic nucleus and in the bacterial nucleoid. In particular, highly transcribed genes, RNA polymerases and transcription factors gather into discrete spat

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https://hal.archives-ouvertes.fr/hal-00484355

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