Zobrazeno 1 - 10
of 773
pro vyhledávání: '"Computational protein design"'
Publikováno v:
Synthetic and Systems Biotechnology, Vol 9, Iss 2, Pp 217-222 (2024)
The protein inverse folding problem, designing amino acid sequences that fold into desired protein structures, is a critical challenge in biological sciences. Despite numerous data-driven and knowledge-driven methods, there remains a need for a user-
Externí odkaz:
https://doaj.org/article/762b6f7f54c245aa81c0ea7d21056e87
Autor:
Bhargava Nemmaru, Jenna Douglass, John M. Yarbrough, Antonio DeChellis, Srivatsan Shankar, Alina Thokkadam, Allan Wang, Shishir P. S. Chundawat
Publikováno v:
Frontiers in Energy Research, Vol 12 (2024)
Non-productive binding of cellulolytic enzymes to various plant cell wall components, such as lignin and cellulose, necessitates high enzyme loadings to achieve efficient conversion of pretreated lignocellulosic biomass to fermentable sugars. Protein
Externí odkaz:
https://doaj.org/article/e572b85ec8494c48b8dd08439db22195
Akademický článek
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Autor:
Rahul Kaushik, Kam Y.J. Zhang
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6467-6472 (2022)
The structural information of a protein is pivotal to comprehend its functions, protein–protein and protein–ligand interactions. There is a widening gap between the number of known protein sequences and that of experimentally determined structure
Externí odkaz:
https://doaj.org/article/ce3de8e08fbc425c9e2418937d256f61
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 3019-3029 (2022)
One of the hallmarks of cancer cells is their ability to evade apoptosis, which confers survival advantages and resistance to anti-cancer drugs. Cancers often exhibit overexpression of anti-apoptotic BCL-2 proteins, the loss of which triggers apoptos
Externí odkaz:
https://doaj.org/article/e94f73b8a32b430ca36ac6aca0a17acd
Autor:
Stephen McCarthy, Shane Gonen
Publikováno v:
Heliyon, Vol 8, Iss 12, Pp e12280- (2022)
Symmetric protein assemblies play important roles in nature which makes them an attractive target for engineering. De novo symmetric protein complexes can be created through computational protein design to tailor their properties from first principle
Externí odkaz:
https://doaj.org/article/ca2b963ab29940809abafc77d94f9b25
Autor:
Ali Bootwala, Hyun Hwan An, Meghan Whitney Franklin, Benjamin J. Manning, Lucy Y. Xu, Shruti Panchal, Joseph D. Garlick, Reshica Baral, Michael E. Hudson, Gevorg Grigoryan, Mark A. Murakami, Kristen Hopson, Daniel S. Leventhal
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The optimal use of many biotherapeutics is restricted by Anti-drug antibodies (ADAs) and hypersensitivity responses which can affect potency and ability to administer a treatment. Here we demonstrate that Re-surfacing can be utilized as a generalizab
Externí odkaz:
https://doaj.org/article/4a3b4c9302ed43f8bcb616f28001d45c
Akademický článek
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Akademický článek
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Publikováno v:
Molecules, Vol 28, Iss 14, p 5353 (2023)
Wild-type cytochrome P450 CYP102A1 from Bacillus megaterium is a highly efficient monooxygenase for the oxidation of long-chain fatty acids. The unique features of CYP102A1, such as high catalytic activity, expression yield, regio- and stereoselectiv
Externí odkaz:
https://doaj.org/article/f539e846aed847418c23b2b85ba06f46