Ratio-based analysis of differential mRNA processing and expression of a polyadenylation factor mutant pcfs4 using arabidopsis tiling microarray

Autor: Yingjia Shen, Denghui Xing, Xiaohui Wu, Jianti Zheng, Qingshun Quinn Li, Diana M. Kroll, Guoli Ji

Publikováno v: PLoS ONE, Vol 6, Iss 2, p e14719 (2011)
PLoS ONE

Background Alternative polyadenylation as a mechanism in gene expression regulation has been widely recognized in recent years. Arabidopsis polyadenylation factor PCFS4 was shown to function in leaf development and in flowering time control. The func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d9f1e12016139a762bdecec90cdcdb6
http://europepmc.org/articles/PMC3045369?pdf=render

Accurate protein structure annotation through competitive diffusion of enzymatic functions over a network of local evolutionary similarities

Autor: Andreas Martin Lisewski, Serkan Erdin, Shivas R. Amin, Eric Venner, R. Matthew Ward, Olivier Lichtarge

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e14286 (2010)
PLoS ONE

High-throughput Structural Genomics yields many new protein structures without known molecular function. This study aims to uncover these missing annotations by globally comparing select functional residues across the structural proteome. First, Evol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153b0e98abbe5ff0c7aca65b345c4341
http://europepmc.org/articles/PMC3001439?pdf=render

Networks of high mutual information define the structural proximity of catalytic sites: implications for catalytic residue identification

Autor: Morten Nielsen, José M. Delfino, Elin Teppa, Cristina Marino Buslje, Tomás Di Domenico

Publikováno v: PLoS Computational Biology, Vol 6, Iss 11, p e1000978 (2010)
PLoS Computational Biology
Buslje, C M, Teppa, E, Di Doménico, T, Delfino, J M & Nielsen, M 2010, ' Networks of High Mutual Information Define the Structural Proximity of Catalytic Sites: Implications for Catalytic Residue Identification ', P L o S Computational Biology (Online), vol. 6, no. 11 . https://doi.org/10.1371/journal.pcbi.1000978
Scopus-Elsevier

Identification of catalytic residues (CR) is essential for the characterization of enzyme function. CR are, in general, conserved and located in the functional site of a protein in order to attain their function. However, many non-catalytic residues

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3259373c836d5c8f01d79c0bf53d16e
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21079665/?tool=EBI

Sub-Nanoscale Surface Ruggedness Provides a Water-Tight Seal for Exposed Regions in Soluble Protein Structure

Autor: Erica Patricia Schulz, Marisa Alejandra Frechero, Gustavo A. Appignanesi, Ariel Fernández

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 9 (2010)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Soluble proteins must maintain backbone hydrogen bonds (BHBs) water-tight to ensure structural integrity. This protection is often achieved by burying the BHBs or wrapping them through intermolecular associations. On the other hand, water has low coo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42839b2af651625a2d5513f300caeec9
http://europepmc.org/articles/PMC2941462

Molecular modeling of mechanosensory ion channel structural and functional features

Autor: Renate Gessmann, Kyriacos Petratos, Nikos Kourtis, Nektarios Tavernarakis

Publikováno v: PLoS ONE, Vol 5, Iss 9, p e12814 (2010)
PLoS ONE

The DEG/ENaC (Degenerin/Epithelial Sodium Channel) protein family comprises related ion channel subunits from all metazoans, including humans. Members of this protein family play roles in several important biological processes such as transduction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ff382b1133dcce92aaa91229570de0
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20877470/?tool=EBI