Systematic dissection and trajectory-scanning mutagenesis of the molecular interface that ensures specificity of two-component signaling pathways

Autor: Emma A. Lubin, Barrett S. Perchuk, Jeffrey M. Skerker, Orr Ashenberg, Emily J. Capra, Michael T. Laub

Publikováno v: PLoS Genetics, Vol 6, Iss 11, p e1001220 (2010)
PLoS
PLoS Genetics

Two-component signal transduction systems enable bacteria to sense and respond to a wide range of environmental stimuli. Sensor histidine kinases transmit signals to their cognate response regulators via phosphorylation. The faithful transmission of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cdd0fe220c69398bdbd10c8834e724
http://europepmc.org/articles/PMC2991266?pdf=render

Networks of high mutual information define the structural proximity of catalytic sites: implications for catalytic residue identification

Autor: Morten Nielsen, José M. Delfino, Elin Teppa, Cristina Marino Buslje, Tomás Di Domenico

Publikováno v: PLoS Computational Biology, Vol 6, Iss 11, p e1000978 (2010)
PLoS Computational Biology
Buslje, C M, Teppa, E, Di Doménico, T, Delfino, J M & Nielsen, M 2010, ' Networks of High Mutual Information Define the Structural Proximity of Catalytic Sites: Implications for Catalytic Residue Identification ', P L o S Computational Biology (Online), vol. 6, no. 11 . https://doi.org/10.1371/journal.pcbi.1000978
Scopus-Elsevier

Identification of catalytic residues (CR) is essential for the characterization of enzyme function. CR are, in general, conserved and located in the functional site of a protein in order to attain their function. However, many non-catalytic residues

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3259373c836d5c8f01d79c0bf53d16e
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21079665/?tool=EBI

Domain altering SNPs in the human proteome and their impact on signaling pathways

Autor: Yichuan Liu, Aydin Tozeren

Publikováno v: PLoS ONE, Vol 5, Iss 9, p e12890 (2010)
PLoS ONE

Single nucleotide polymorphisms (SNPs) constitute an important mode of genetic variations observed in the human genome. A small fraction of SNPs, about four thousand out of the ten million, has been associated with genetic disorders and complex disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5547dbd5218e97f977b64bdf40650dc2
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20886114/pdf/?tool=EBI

Molecular modeling of mechanosensory ion channel structural and functional features

Autor: Renate Gessmann, Kyriacos Petratos, Nikos Kourtis, Nektarios Tavernarakis

Publikováno v: PLoS ONE, Vol 5, Iss 9, p e12814 (2010)
PLoS ONE

The DEG/ENaC (Degenerin/Epithelial Sodium Channel) protein family comprises related ion channel subunits from all metazoans, including humans. Members of this protein family play roles in several important biological processes such as transduction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ff382b1133dcce92aaa91229570de0
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20877470/?tool=EBI

Symmetric key structural residues in symmetric proteins with beta-trefoil fold

Autor: Yanzhao Huang, Jianhui Feng, Yi Xiao, Mingfeng Li

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 11, p e14138 (2010)

To understand how symmetric structures of many proteins are formed from asymmetric sequences, the proteins with two repeated beta-trefoil domains in Plant Cytotoxin B-chain family and all presently known beta-trefoil proteins are analyzed by structur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e45a80ea1a176153d4a7279a24d083
https://pubmed.ncbi.nlm.nih.gov/21152439