Zobrazeno 1 - 10
of 305
pro vyhledávání: '"Components of the Immune System"'
Autor:
Cecilia Fahlquist-Hagert, Thomas Rea Wittenborn, Mattias Krogh Pedersen, Lisbeth Jensen, Søren Egedal Degn
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110887- (2024)
Summary: Autoantibodies generated in germinal centers (GCs) contribute to the pathogenesis of autoimmune diseases. GCs are controlled by specialized FoxP3+ T-follicular regulatory cells (Tfr), but their role in established autoimmunity is unclear. We
Externí odkaz:
https://doaj.org/article/c7ff3c58a05746c98976385d37751a35
Autor:
Matthijs J.D. Baars, Evelien Floor, Neeraj Sinha, José J.M. ter Linde, Stephanie van Dam, Mojtaba Amini, Isaäc J. Nijman, Joren R. ten Hove, Julia Drylewicz, G.Johan A. Offerhaus, Miangela M. Laclé, Bas Oldenburg, Yvonne Vercoulen
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110550- (2024)
Summary: Patients with long-standing inflammatory bowel disease (IBD) face an increased risk of developing colitis-associated cancer (CAC). Although IBD-induced prolonged inflammation seems to be involved in CAC pathogenesis, the specific molecular c
Externí odkaz:
https://doaj.org/article/589bcf3cd14349a187c71e387a5367fd
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110528- (2024)
Summary: Circulating T cells, which migrate from the periphery to sites of tissue inflammation, play a crucial role in the development of various chronic inflammatory conditions. Recent research has highlighted subsets of tissue-resident T cells that
Externí odkaz:
https://doaj.org/article/becaae96c98848c68844dd539fbda8f3
Autor:
Marco R. Bladergroen, Tamas Pongracz, Wenjun Wang, Simone Nicolardi, Sesmu M. Arbous, Anna Roukens, Manfred Wuhrer
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110374- (2024)
Summary: Total plasma protein N-glycosylation (TPNG) changes are a hallmark of many diseases. Here, we analyzed the TPNG of 169 COVID-19 patients and 12 healthy controls, using mass spectrometry, resulting in the relative quantification of 85 N-glyca
Externí odkaz:
https://doaj.org/article/361a6771232c499a9447afbc045d63f3
Autor:
Patricia A. Assis, Ronald M. Allen, Matthew A. Schaller, Steven L. Kunkel, Jennifer R. Bermick
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110114- (2024)
Summary: Sepsis survivors are at high risk for infection-related rehospitalization and mortality for years following the resolution of the acute septic event. These infection-causing microorganisms generally do not cause disease in immunocompetent ho
Externí odkaz:
https://doaj.org/article/18e590a40ae8482c8753a9df7aa72c04
Autor:
Ronan C. Bracken, Lindsay M. Davison, Dennis P. Buehler, Maci E. Fulton, Emily E. Carson, Quanhu Sheng, Lindsey K. Stolze, Christelle Guillermier, Matthew L. Steinhauser, Jonathan D. Brown
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110011- (2024)
Summary: Combinatorial signaling by proinflammatory cytokines synergizes to exacerbate toxicity to cells and tissue injury during acute infections. To explore synergism at the gene-regulatory level, we investigated the dynamics of transcription and c
Externí odkaz:
https://doaj.org/article/968e40391d4f4f4f936e241935d0f84b
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110097- (2024)
Summary: Systemic neutrophil dysregulation contributes to atherosclerosis pathogenesis, and restoring neutrophil homeostasis may be beneficial for treating atherosclerosis. Herein, we report that a homeostatic resolving subset of neutrophils exists i
Externí odkaz:
https://doaj.org/article/3513ac0002b1471c86347db97531e2f2
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110067- (2024)
Summary: Dendritic cells (DC) play a crucial role in the initiation of immune responses. TRIM41, an E3 ubiquitin ligase, can facilitate targeting protein degradation. The purpose of this study is to analyze the role of TRIM41 in the pathogenesis of a
Externí odkaz:
https://doaj.org/article/129e5062009e45a0b3aba1b3d9692379
Autor:
Nicole S. Sarna, Shanay H. Desai, Benjamin G. Kaufman, Natalie M. Curry, Anne M. Hanna, Michael R. King
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109999- (2024)
Summary: The efficacy of T cell therapies in treating solid tumors is limited by poor in vivo persistence, proliferation, and cytotoxicity, which can be attributed to limited and variable ex vivo activation. Herein, we present a 10-day kinetic profil
Externí odkaz:
https://doaj.org/article/efd8f64110df41aa8dc6ed0f2c165f50
Autor:
Flavia Giannessi, Zulema Percario, Valentina Lombardi, Andrea Sabatini, Alessandra Sacchi, Veronica Lisi, Luca Battistini, Giovanna Borsellino, Elisabetta Affabris, Daniela F. Angelini
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109960- (2024)
Summary: Limited information exists regarding the impact of interferons (IFNs) on the information carried by extracellular vesicles (EVs). This study aimed at investigating whether IFN-α2b, IFN-β, IFN-γ, and IFN-λ1/2 modulate the content of EVs r
Externí odkaz:
https://doaj.org/article/4a8663a5a64f4802b47c701a3736fe80