Zobrazeno 1 - 10
of 360
pro vyhledávání: '"Complement component C3"'
Autor:
Dinko Šoić, Jerko Štambuk, Marko Tijardović, Toma Keser, Gordan Lauc, Tomislav Bulum, Marijana Vučić Lovrenčić, Sandra Vučković Rebrina, Martina Tomić, Mislav Novokmet, Lea Smirčić-Duvnjak, Olga Gornik
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
AimChanges in N-glycosylation have been described in numerous diseases and are being considered as biomarkers of ongoing pathological condition. Previous studies demonstrated the interrelation of N-glycosylation and type 1 diabetes (T1D), particularl
Externí odkaz:
https://doaj.org/article/76ef09323a1d4b40af492af36c42a050
Autor:
Anne Landsem, Åse Emblem, Corinna Lau, Dorte Christiansen, Alexandra Gerogianni, Bård Ove Karlsen, Tom Eirik Mollnes, Per H. Nilsson, Ole-Lars Brekke
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionPlatelets have essential functions as first responders in the immune response to pathogens. Activation and aggregation of platelets in bacterial infections can lead to life-threatening conditions such as arterial thromboembolism or sepsis
Externí odkaz:
https://doaj.org/article/0679ee2f1ecd4d07aa04f0face1e0719
Publikováno v:
Molecules, Vol 28, Iss 14, p 5363 (2023)
Highly neurotoxic A1-reactive astrocytes have been associated with several human neurodegenerative diseases. Complement protein C3 expression is strongly upregulated in A1 astrocytes, and this protein has been shown to be a specific biomarker of thes
Externí odkaz:
https://doaj.org/article/bdd2b3fb6c454afdbb6c5b5700076128
Autor:
Margalida Mateu-Borrás, Laura Zamorano, Alex González-Alsina, Irina Sánchez-Diener, Antonio Doménech-Sánchez, Antonio Oliver, Sebastián Albertí
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)
Pseudomonas aeruginosa is a major cause of nosocomial bloodstream infections. This microorganism secretes two major proteases, alkaline protease A (AprA) and elastase B (LasB). Despite several in vitro studies having demonstrated that both purified p
Externí odkaz:
https://doaj.org/article/a96118ef6722402c84c059c4a94e537e
Publikováno v:
International Journal of Behavioral Nutrition and Physical Activity, Vol 14, Iss 1, Pp 1-12 (2017)
Abstract Background Sedentary behaviour, obesity and insulin resistance are associated with pro-inflammatory status. Limited data on whether physical activity modulates inflammatory status and counteracts obesity and insulin resistance associated low
Externí odkaz:
https://doaj.org/article/9b7ddd3c4fda4b63870eaed388e1f3ea
Publikováno v:
Renal Replacement Therapy, Vol 3, Iss 1, Pp 1-10 (2017)
Abstract Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Most cases of aHUS are caused by uncontrolled complement activatio
Externí odkaz:
https://doaj.org/article/e9599809750e415dba87f98ebe15a441
Autor:
Dennis V. Pedersen, Trine A. F. Gadeberg, Caroline Thomas, Yong Wang, Nicolas Joram, Rasmus K. Jensen, Sofia M. M. Mazarakis, Margot Revel, Carine El Sissy, Steen V. Petersen, Kresten Lindorff-Larsen, Steffen Thiel, Nick S. Laursen, Véronique Fremeaux-Bacchi, Gregers R. Andersen
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Properdin (FP) is a positive regulator of the immune system stimulating the activity of the proteolytically active C3 convertase C3bBb in the alternative pathway of the complement system. Here we present two crystal structures of FP and two structure
Externí odkaz:
https://doaj.org/article/ac896c2448754a3fb20a2396a833fbe7
Akademický článek
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Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Autor:
Jennifer G. Nolasco, Leticia H. Nolasco, Qi Da, Sonya Cirlos, Zaverio M. Ruggeri, Joel L. Moake, Miguel A. Cruz
Publikováno v:
TH Open, Vol 02, Iss 03, Pp e338-e345 (2018)
von Willebrand factor (VWF) is a multimeric protein composed of monomeric subunits (∼280 kD) linked by disulfide bonds. During hemostasis and thrombosis, ultralarge (UL) VWF (ULVWF) multimers initiate platelet adhesion. In vitro, human C3 binds to
Externí odkaz:
https://doaj.org/article/3336b2a3967c45acbd64eff286c182c8