Complement inhibitor CD55 governs the integrity of membrane rafts in pancreatic beta cells, but plays no role in insulin secretion

Autor: Petter Storm, Erik Renström, Ben C. King, Petter Vikman, Emilia Ottosson-Laakso, Anna M. Blom, Vini Nagaraj

Publikováno v: Biochemical and Biophysical Research Communications; 460(3), pp 518-524 (2015)

CD55 is a glycosylphosphatidylinositol-anchored protein, which inhibits complement activation by acting on the complement C3 convertases. CD55 is widely localized in the cholesterol rich regions of the cell plasma membrane termed membrane rafts. CD55

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5931b947af4465c1169d9be4c786ba42
https://pubmed.ncbi.nlm.nih.gov/25797618

A Corresponding Tyrosine Residue in the C2/Factor B Type A Domain Is a Hot Spot in the Decay Acceleration of the Complement C3 Convertases

Autor: Lynne M. Mitchell, Nasima Muqim, M. Edward Medof, Megan P. Dybvig, John P. Atkinson, Lisa Kuttner-Kondo, Dennis E. Hourcade

Publikováno v: Journal of Biological Chemistry. 278:52386-52391

The cleavage of C3 by the C3 convertases (C3bBb and C4b2a) determines whether complement activation proceeds. Dissociation (decay acceleration) of these central enzymes by the regulators decay-accelerating factor (DAF), complement receptor 1 (CR1), f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7160ab2104916ed0db601e388109c335
https://doi.org/10.1074/jbc.m304620200

An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)

Autor: Selina Stippa, Jörg Köhl, Peter F. Zipfel, Martin Oppermann, Christine Skerka, Lars G. Fritsche, Bernhard H. F. Weber, Manoj K. Pandey, Andrea Hartmann, Claudia N. Keilhauer, Nadine Lauer

Publikováno v: Human molecular genetics. 19(23)

A frequent deletion of complement factor H (CFH)-related genes CFHR3 and CFHR1 (ΔCFHR3/CFHR1) is considered to have a protective effect against age-related macular degeneration (AMD), although the underlying mechanism remains elusive. The deletion s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8a78d95aa41bc32f3e2c1c83764839
https://pubmed.ncbi.nlm.nih.gov/20843825

Die pharmakologische Inhibition der intrazerebralen Entzündungsreaktion durch systemische Administration des rekombinanten Komplement-Inhibitors Crry-Ig vermittelt eine Neuroprotektion im experimentellen Schädel-Hirn-Trauma in der Maus

Autor: A. Scheffler, Wolfgang Ertel, Philip F. Stahel, V. M. Holers, Amir M. Hossini, C. E. Heyde, Iris Leinhase, Oliver I. Schmidt

Publikováno v: Chirurgisches Forum 2005 ISBN: 3540248889
122. Kongress der Deutschen Gesellschaft für Chirurgie; 20050405-20050408; München; DOC05dgch2629 /20050615/

Activation of complement plays a central role in the pathogenesis of neuroinflammation leading to secondary brain injury following a traumatic insult to the brain. In a previous study, we were able to show improved neurological recovery in brain-inju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1be05516988177f94d406f90beabf1d
https://doi.org/10.1007/3-540-26560-0_117

Alternative pathway of complement: recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of the pathway

Autor: H J Müller-Eberhard, Otto Götze, R G Medicus

Publikováno v: The Journal of Experimental Medicine

In this study the physiological role of properdin and the differential subunit composition of the solid phase enzymes of the pathway have been explored. Cell-bound C3 and C5 convertase differ in their C3b requirement. Apparently one molecule of C3b i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e88dca879c717f13a3f5f6246efb7c
https://doi.org/10.1084/jem.144.4.1076