Optimization of pyridylpiperazine-based inhibitors of the Escherichia coli AcrAB-TolC efflux pump

Autor: Compagne, Nina, Jiménez-Castellanos, Juan-Carlos, Meurillon, Virginie, Pradel, Elizabeth, Vieira Da Cruz, Anais, Piveteau, Catherine, Biela, Alexandre, Eveque, Maxime, Leroux, Florence, Deprez, Benoit, Willand, Nicolas, Hartkoorn, Ruben C., Flipo, Marion

Publikováno v: In European Journal of Medicinal Chemistry 5 November 2023 259

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On the Hunt for Next-Generation Antimicrobial Agents: An Online Symposium Organized Jointly by the French Society for Medicinal Chemistry (Société de Chimie Thérapeutique) and the French Microbiology Society (Société Française de Microbiologie) on 9–10 December 2021

Autor: Antraygues, Kevin¹ (AUTHOR) kevin.antraygues@univ-lille.fr, Compagne, Nina¹ (AUTHOR) nina.compagne.etu@univ-lille.fr, Ruggieri, Francesca¹ (AUTHOR) francesca.ruggieri@univ-lille.fr, Djaout, Kamel² (AUTHOR) kamel.djaout@ibl.cnrs.fr, Edoo, Zainab² (AUTHOR) zainab.edoo@inserm.fr, Eveque, Maxime¹ (AUTHOR) maxime.eveque@univ-lille.fr, Faïon, Léo¹ (AUTHOR) leo.faion@univ-lille.fr, Gioia, Bruna¹ (AUTHOR) bruna.gioia@univ-lille.fr, Tangara, Salia¹ (AUTHOR) salia.tangara@univ-lille.fr, Vieira Da Cruz, Anais¹ (AUTHOR) anais.vieira-da-cruz@inserm.fr, Villemagne, Baptiste¹ (AUTHOR) baptiste.villemagne@univ-lille.fr, Flipo, Marion¹ (AUTHOR) marion.flipo@univ-lille.fr, Baulard, Alain² (AUTHOR) alain.baulard@pasteur-lille.fr, Willand, Nicolas¹ (AUTHOR) alain.baulard@pasteur-lille.fr

Publikováno v: Pharmaceuticals (14248247). Apr2022, Vol. 15 Issue 4, pN.PAG-N.PAG. 14p.

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Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae.

Autor: Vieira Da Cruz A; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000, Lille, France., Jiménez-Castellanos JC; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, F-59000, Lille, France., Börnsen C; Buchmann Institute for Molecular Life Sciences and Institute for Biophysics, Goethe University Frankfurt, Max-von-Laue-Str. 15, D-60438, Frankfurt am Main, Germany., Van Maele L; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, F-59000, Lille, France., Compagne N; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000, Lille, France., Pradel E; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, F-59000, Lille, France., Müller RT; Institute of Biochemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 9, D-60438, Frankfurt am Main, Germany., Meurillon V; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000, Lille, France., Soulard D; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, F-59000, Lille, France., Piveteau C; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000, Lille, France., Biela A; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000, Lille, France., Dumont J; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000, Lille, France., Leroux F; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000, Lille, France.; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur Lille, US 41-UAR 2014-PLBS, F-59000, Lille, France., Deprez B; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000, Lille, France., Willand N; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000, Lille, France., Pos KM; Institute of Biochemistry, Goethe-University Frankfurt, Max-von-Laue-Str. 9, D-60438, Frankfurt am Main, Germany. pos@em.uni-frankfurt.de., Frangakis AS; Buchmann Institute for Molecular Life Sciences and Institute for Biophysics, Goethe University Frankfurt, Max-von-Laue-Str. 15, D-60438, Frankfurt am Main, Germany. achilleas.frangakis@biophysik.org., Hartkoorn RC; Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, F-59000, Lille, France. ruben.hartkoorn@inserm.fr., Flipo M; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000, Lille, France. marion.flipo@univ-lille.fr.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2024 Jan; Vol. 16 (1), pp. 93-111. Date of Electronic Publication: 2023 Dec 20.