Zobrazeno 1 - 10
of 231
pro vyhledávání: '"Commandeur, J.N.M."'
Autor:
Capinha, L., Zhang, Y., Holzer, A.-K., Ückert, A.-K., Zana, M., Murphy, C., Mazidi, Z., Grillari, J., Commandeur, J.N.M., Dinnyes, A., van der Water, B., Leist, M., Jennings, P.
Publikováno v:
In Toxicology Letters 1 September 2022 368 Supplement:S214-S214
Akademický článek
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Publikováno v:
British Journal of Clinical Pharmacology, 83(3), 572-583. Wiley-Blackwell
Zhang, Y, Vermeulen, N P E & Commandeur, J N M 2017, ' Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N-desethylamodiaquine ', British Journal of Clinical Pharmacology, vol. 83, no. 3, pp. 572-583 . https://doi.org/10.111/bcp.13148, https://doi.org/10.1111/bcp.13148
Zhang, Y, Vermeulen, N P E & Commandeur, J N M 2017, ' Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N-desethylamodiaquine ', British Journal of Clinical Pharmacology, vol. 83, no. 3, pp. 572-583 . https://doi.org/10.111/bcp.13148, https://doi.org/10.1111/bcp.13148
Aims: Oxidative bioactivation of amodiaquine (AQ) by cytochrome P450s to a reactive quinoneimine is considered as an important mechanism underlying its idiosyncratic hepatotoxicity. However, because internal exposure to its major metabolite N-desethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7e20edbd69bfb7bba21f5e369b0ae86c
https://research.vu.nl/en/publications/da5c73e2-baee-41ec-b2ec-b2da8f09b9f0
https://research.vu.nl/en/publications/da5c73e2-baee-41ec-b2ec-b2da8f09b9f0
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Orhan, H.1,2, Commandeur, J.N.M.2, Sahin, G.1, Aypar, U.3, Sahin, A.3, Vermeulen, N.P.E.2 vermeule@few.vu.nl
Publikováno v:
Xenobiotica. Mar2004, Vol. 34 Issue 3, p301-316. 16p. 1 Diagram, 2 Charts, 19 Graphs.
Autor:
Capoferri, L., Leth, R., ter Haar, E., Mohanty, A.K., Grootenhuis, P.D.J., Vottero, E.R., Commandeur, J.N.M., Vermeulen, N.P.E., Jorgensen, F.S., Olsen, L., Geerke, D.P.
Publikováno v:
Capoferri, L, Leth, R, ter Haar, E, Mohanty, A K, Grootenhuis, P D J, Vottero, E R, Commandeur, J N M, Vermeulen, N P E, Jorgensen, F S, Olsen, L & Geerke, D P 2016, ' Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations. ', Proteins, vol. 84, no. 3, pp. 383-396 . https://doi.org/10.1002/prot.24985
Proteins, 84(3), 383-396. Wiley-Liss Inc.
Proteins, 84(3), 383-396. Wiley-Liss Inc.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::43dbe1d3b7a3b5f32fe748dada369460
https://research.vu.nl/en/publications/83a5b71c-8c07-4002-977b-abda6b10f509
https://research.vu.nl/en/publications/83a5b71c-8c07-4002-977b-abda6b10f509
Publikováno v:
Rooseboom, M, Vermeulen, N P E & Commandeur, J N M 2002, ' Enzymatic pathways of beta elimination of chemopreventive selenocysteine Se conjugates ', Methods in Enzymology, vol. 348, pp. 191-200 . https://doi.org/10.1016/S0076-6879(02)48638-7
Methods in Enzymology, 348, 191-200. Academic Press Inc.
Methods in Enzymology, 348, 191-200. Academic Press Inc.
Publikováno v:
Remirez, D, Commandeur, J N M, de Groot, E & Vermeulen, N P E 1995, ' Mechanism of protection of lobenzarit against paracetamol-induced toxicity in rat hepatocytes. ', European Journal of Pharmacology. Environmental Toxicology and Pharmacology Section, vol. 293, pp. 301-308 . https://doi.org/10.1016/S0014-2999(95)80087-5
European Journal of Pharmacology. Environmental Toxicology and Pharmacology Section, 293, 301-308. Elsevier BV
European Journal of Pharmacology. Environmental Toxicology and Pharmacology Section, 293, 301-308. Elsevier BV
Autor:
Kolkman, A.J., Draaisma, V.R.J., Tessari, M., Vottero, E.V., Ampt, K.A.M., Commandeur, J.N.M., Irth, H., Vermeulen, N.P.E., Honing, M., Wijmenga, S.S.
Publikováno v:
Journal of Biomolecular Structure & Dynamics, 2011
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Publikováno v:
Commandeur, J N M, Stijntjes, G J, Wijngaard, J & Vermeulen, N P E 1991, ' Metabolism of L-cysteine S-conjugates and N-(trideuteroacetyl)-L-cysteine S-conjugates of four fluoroethylenes in the rat. Role of balance of deacetylation and acetylation in relation to the nephrotoxicity of mercapturic acids. ', Biochemical Pharmacology, vol. 42, no. 1, pp. 31-38 . https://doi.org/10.1016/0006-2952(91)90677-W
Biochemical Pharmacology, 42(1), 31-38. Elsevier Inc.
Biochemical Pharmacology, 42(1), 31-38. Elsevier Inc.
The relationship between the relative nephrotoxicity of the mercapturic acids (NAc) of the fluorinated ethylanes tetrafluoroethylene (TFE), chlorotrifluoroethylene (CTFE), 1,1-dichloro-2,2-difluoroethylene (DCDFE) and 1,1-dibromo-2,2-difluoroethylene