Efficient pilot-scale synthesis of the key cefonicid intermediate at room temperature

Autor: Comito Marziale, Monguzzi Riccardo, Tagliapietra Silvia, Palmisano Giovanni, Cravotto Giancarlo

Publikováno v: Green Processing and Synthesis, Vol 11, Iss 1, Pp 96-105 (2022)

Cefonicid is a common second-generation cephalosporin, and the 7-amino-3-[sulphomethyl-1-H-tetrazol-5-yl-thiomethyl]-3-cephem-4-carboxylate monosodium salt is a key synthetic intermediate in its preparation. Despite the considerable international dem

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Clinical and biological landscape of constitutional mismatch-repair deficiency syndrome: an International Replication Repair Deficiency Consortium cohort study.

Autor: Ercan AB; Arthur and Sonia Labatt Brain Tumor Research Centre, Toronto, ON, Canada., Aronson M; Zane Cohen Centre for Digestive Diseases, Sinai Health System, Toronto, ON, Canada., Fernandez NR; Arthur and Sonia Labatt Brain Tumor Research Centre, Toronto, ON, Canada., Chang Y; Arthur and Sonia Labatt Brain Tumor Research Centre, Toronto, ON, Canada., Levine A; Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada., Liu ZA; Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada., Negm L; Arthur and Sonia Labatt Brain Tumor Research Centre, Toronto, ON, Canada., Edwards M; Arthur and Sonia Labatt Brain Tumor Research Centre, Toronto, ON, Canada., Bianchi V; Arthur and Sonia Labatt Brain Tumor Research Centre, Toronto, ON, Canada., Stengs L; Arthur and Sonia Labatt Brain Tumor Research Centre, Toronto, ON, Canada., Chung J; Arthur and Sonia Labatt Brain Tumor Research Centre, Toronto, ON, Canada., Al-Battashi A; Department of Pediatric Hematology and Oncology, The Royal Hospital, Muscat, Oman., Reschke A; Division of Pediatric Hematology/Oncology, Stanford Medicine, Stanford, CA, USA., Lion A; Department of Pediatric Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN, USA., Ahmad A; University of Child Health Sciences, Children's Hospital Lahore, Lahore, Pakistan., Lassaletta A; Department of Pediatric Hematology-Oncology, Hospital Infantil Universitario Nino Jesus, Madrid, Spain., Reddy AT; University of California, San Francisco, CA, USA., Al-Darraji AF; College of Medicine, University of Baghdad, Paediatric Oncology Unit, Baghdad, Iraq., Shah AC; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Van Damme A; Division of Pediatric Hematology and Oncology, Institut Roi Albert II, Cliniques Universitaires Saint-Luc, Brussels, Belgium., Bendel A; Children's Minnesota, Minneapolis, MN, USA., Rashid A; Department of Pediatric Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan., Margol AS; Department of Pediatrics, Children's Hospital Los Angeles, Keck School of Medicine University of Southern California, Los Angeles, CA, USA., Kelly BL; CHI-Saint Joseph Health Cancer Care, Lexington, KY, USA., Pencheva B; Alfac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA., Heald B; Department of Gastroenterology, Hepatology, and Nutrition, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA., Lemieux-Anglin B; Departments of Oncology and Human Genetics, McGill University Health Centre, Cancer Genetics Program, Montreal, QC, Canada., Crooks B; Division of Hematology-Oncology, IWK Health, Halifax, NS, Canada., Koschmann C; Department of Pediatric Hematology-Oncology, University of Michigan Medical School, Ann Arbor, MI, USA., Gilpin C; Children's Hospital of Eastern Ontario, Genetics, Ottawa, ON, Canada., Porter CC; Alfac Cancer & Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA., Gass D; Department of Pediatric Hematology and Oncology, Atrium Health, Charlotte, NC, USA., Samuel D; Valley Children's Hospital, Madera, CA, USA., Ziegler DS; Kid's Cancer Centre, Sydney Children's Hospital, Sydney, NSW, Australia., Blumenthal DT; Neuro-Oncology Division, Tel Aviv Medical Center, Tel Aviv University, Tel Aviv, Israel., Kuo DJ; Division of Pediatric Hematology/Oncology, University of California, San Diego, CA, USA., Hamideh D; Division of Pediatric Hematology-Oncology, American University of Beirut, Beirut, Lebanon., Basel D; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA., Khuong-Quang DA; Children's Cancer Centre, The Royal Children's Hospital, Melbourne, VIC, Australia., Stearns D; UH Rainbow Babies and Children's Hospital Division of Pediatrics, Pediatric Neuro-oncology, Cleveland, OH, USA., Opocher E; Pediatric Hematology, Oncology and Stem Cell Transplant Division, Padua University Hospital, Padua, Italy., Carceller F; Children and Young People's Unit, Royal Marsden NHS Foundation Trust, London, UK; Division of Clinical Studies, The Institute of Cancer Research, London, UK., Baris Feldman H; The Genetics Institute and Genomics Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel., Toledano H; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Pediatric Hematology-Oncology, Schneider Children's Medical Center, Petah Tikva, Israel., Winer I; Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA., Scheers I; Division of Pediatric Gastroenterology and Hepatology, Cliniques Universitaires Saint-Luc, IREC Universite Catholique de Louvain, Brussels, Belgium., Fedorakova I; Clinic of Pediatric Oncology and Hematology, University Children's Hospital, Banská Bystrica, Slovakia., Su JM; Department of Pediatrics, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, TX, USA., Vengoechea J; Associate Professor of Human Genetics, Emory University, Atlanta, GA, USA., Sterba J; Pediatric Oncology Department, University Hospital Brno, Masaryk Univerzity, Faculty of Medicine, Brno, Czech Republic., Knipstein J; Division of Pediatric Hematology/Oncology/Blood and Marrow Transplant, Medical College of Wisconsin, Milwaukee, WI, USA., Hansford JR; Michael Rice Children's Hematology and Oncology Centre, Women's and Children's Hospital, Adelaide, SA, Australia; South Australia Health and Medical Research Institute Adelaide, SA, Australia; South Australia Immunogenomics Cancer Institute, University of Adelaide, Adelaide, SA, Australia., Gonzales-Santos JR; De La Salle Medical and Health Sciences Institute, Dasmariñas, Philippines., Bhatia K; Children's Cancer Centre, The Royal Children's Hospital, Melbourne, VIC, Australia., Bielamowicz KJ; Department of Pediatrics, Division of Hematology/Oncology, University of Arkansas for Medical Sciences/Arkansas Children's Hospital, Little Rock, AR, USA., Minhas K; Division of Histopathology, Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan., Nichols KE; Department of Oncology, St Jude Children's Research Hospital, Memphis, TN, USA., Cole KA; Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Penney L; Division of Medical Genetics, Department of Pediatrics, IWK Health Centre, Halifax, NS, Canada., Hjort MA; Children's Clinic, St Olavs University Hospital, Trondheim, Norway., Sabel M; Department of Pediatrics, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Gil-da-Costa MJ; Pediatric Oncology Department, University Hospital de São João, Porto, Portugal., Murray MJ; Department of Pathology, University of Cambridge, Cambridge, UK., Miller M; Division of Hematology and Oncology, Oregon Health & Science University, Portland, OR, USA., Blundell ML; Sutter Health, Cancer Risk Program, Sacramento, CA, USA., Massimino M; Pediatric Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Al-Hussaini M; King Hussein Cancer Center, Amman, Jordan., Al-Jadiry MF; College of Medicine, University of Baghdad, Paediatric Oncology Unit, Baghdad, Iraq., Comito MA; Golisano Children's Hospital, SUNY Upstate, Syracuse, NY, USA., Osborn M; Michael Rice Children's Hematology and Oncology Centre, Women's and Children's Hospital, Adelaide, SA, Australia., Link MP; Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA., Zapotocky M; Department of Paediatric Haematology and Oncology, University Hospital Motol and Second Faculty of Medicine, Charles University, Prague, Czech Republic., Ghalibafian M; MAHAK Pediatric Cancer Treatment and Research, Tehran, Iran., Shaheen N; Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan., Mushtaq N; Aga Khan University Hospital, Karachi, Pakistan., Waespe N; Division of Pediatric Oncology and Hematology, Department of Pediatrics, Inselspital, Bern University Hospital, Bern, Switzerland., Hijiya N; Pediatric Hematology Oncology and Stem Cell Transplant, Columbia University Irving Medical Center, New York, NY, USA., Fuentes-Bolanos N; Kid's Cancer Centre, Sydney Children's Hospital, Sydney, NSW, Australia., Ahmad O; Hopp Children's Cancer Center, King Fahad Specialist Hospital, Dammam, Saudi Arabia., Chamdine O; Department of Pediatric Hematology Oncology, King Fahad Specialist Hospital, Dammam, Saudi Arabia., Roy P; Department of Pathology, Tata Medical Center, Rajarhat, Kolkata, India., Pichurin PN; Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA., Nyman P; Crown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden; Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden., Pearlman R; Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA., Auer RC; Ottawa Hospital Research Institute, Ottawa, ON, Canada., Sukumaran RK; Department of Pediatric Hemato-oncology, Tata Medical Center, Kolkata, India., Kebudi R; Department of Pediatric Hematology-Oncology, Istanbul University, Oncology Institute, Istanbul, Türkiye., Dvir R; Department of Pediatric Hemato-Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Raphael R; UCSF Benioff Children's Hospital Oakland, Oakland, CA, USA., Elhasid R; Department of Pediatric Hemato-Oncology, Tel Aviv Medical Center, Tel Aviv, Israel., McGee RB; St Jude Children's Research Hospital, Memphis, TN, USA., Chami R; Division of Pathology, The Hospital for Sick Children, Toronto, ON, Canada., Noss R; Center for Personalized Genetic Healthcare, Cleveland Clinic, Cleveland, OH, USA., Tanaka R; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA., Raskin S; Department of Pediatrics, Federal University of Parana, Curitiba, Parana., Sen S; Department of Pediatric Hematology, Oncology, and Bone Marrow Transplant, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, India., Lindhorst S; Department of Neurosurgery, Division of Neuro-Oncology, Medical University of South Carolina, Charleston, SC, USA., Perreault S; Division of Child Neurology, Department of Pediatrics, CHU Sainte-Justine, Université de Montréal, Montreal, QC, Canada., Caspi S; Sheba Medical Center, Cancer Research Center, Tel Hashomer, Israel., Riaz S; Department of Hematology and Oncology, The Children's Hospital and University of Child Health Sciences, Lahore, Pakistan., Constantini S; Department of Pediatric Neurosurgery, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Albert S; Cancer Axis, Lady Davis Institute, Jewish General Hospital, Montreal, QC Canada., Chaleff S; Maine Children's Cancer Program, Portland, ME, USA., Bielack S; Padiatrie 5 (Onkologie, Hamatologie, Immunologie), Zentrum fur Kinder-, Jugend- und Frauenmedizin, Stuttgart Cancer Center, Klinikum Stuttgart-Olgahospital, Stuttgart, Germany., Chiaravalli S; Pediatric Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Cramer SL; Department of Pediatric Hematology/Oncology, Prisma Health, Columbia, SC, USA., Roy S; Central Michigan University, Mount Pleasant, MI, USA; Division of Genetics, Genomic & Metabolic Disorders, Pediatric Cancer Genetics Clinic, Children's Hospital of Michigan, Detroit, MI, USA., Cahn S; Winship Cancer Institute, Emory University Hospital, Atlanta, GA, USA., Penna S; Division of Rehabilitation Neuropsychology, Emory University School of Medicine, Atlanta, GA, USA., Hamid SA; Indus Hospital and Health Network, Karachi, Pakistan., Ghafoor T; Department of Hematology and Stem Cell Transplant, Armed Forces Bone Marrow Transplant Center, National Institute of Blood and Marrow Transplant, Rawalpindi, Pakistan., Imam U; Pediatric Oncology Department, National Institute of Child Health, Karachi, Pakistan., Larouche V; Department of Hematology-Oncology, CHU de Quebec-Universite Laval, Quebec, QC, Canada., Magimairajan Issai V; Department of Pediatric Hematology-Oncology, CancerCare Manitoba, Winnipeg, MB, Canada., Foulkes WD; Departments of Oncology and Human Genetics, McGill University Health Centre, Cancer Genetics Program, Montreal, QC, Canada., Lee YY; Department of Neurosurgery, Taipei Veterans General Hospital, Taipei, Taiwan., Nathan PC; Division of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada., Maruvka YE; Faculty of Biotechnology and Food Engineering, The Lokey Center for Life Science and Engineering, TECHNION-Israel Institute of Technology, Haifa, Israel., Greer MC; Department of Diagnostic and Interventional Radiology, The Hospital for Sick Children, Toronto, ON, Canada., Durno C; Division of Gastroenterology, Hepatology, and Nutrition, The Hospital for Sick Children, Toronto, ON, Canada., Shlien A; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Ertl-Wagner B; Department of Diagnostic Imaging, The Hospital for Sick Children, Toronto, ON, Canada; Department of Medical Imaging, University of Toronto, Toronto, ON, Canada., Villani A; Division of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada., Malkin D; Division of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada., Hawkins C; Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada., Bouffet E; Division of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada., Das A; Arthur and Sonia Labatt Brain Tumor Research Centre, Toronto, ON, Canada; Division of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada., Tabori U; Arthur and Sonia Labatt Brain Tumor Research Centre, Toronto, ON, Canada; Division of Hematology and Oncology, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address: uri.tabori@sickkids.ca.

Publikováno v: The Lancet. Oncology [Lancet Oncol] 2024 May; Vol. 25 (5), pp. 668-682. Date of Electronic Publication: 2024 Mar 26.

The impacts of total body irradiation on umbilical cord blood hematopoietic stem cell transplantation.

Autor: Wang H; Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Berger KN; Penn State Hershey Cancer Institute, College of Medicine, Pennsylvania State University, Hershey, PA, USA., Miller EL; Penn State Hershey Cancer Institute, College of Medicine, Pennsylvania State University, Hershey, PA, USA., Fu W; Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Broglie L; Division of Hematology and Oncology - Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA., Goldman FD; Division of Hematology and Oncology, The University of Alabama at Birmingham, Birmingham, AB, USA., Konig H; Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA., Lim SJ; Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Berg AS; Penn State Hershey Cancer Institute, College of Medicine, Pennsylvania State University, Hershey, PA, USA., Talano JA; Division of Hematology and Oncology - Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA., Comito MA; Penn State Hershey Cancer Institute, College of Medicine, Pennsylvania State University, Hershey, PA, USA., Farag SS; Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, IN, USA., Pu JJ; Cancer Center, The University of Arizona, 1515 N Campbell Avenue, Room#1968C, Tucson, AZ 85724, USA.; Penn State Hershey Cancer Institute, College of Medicine, Pennsylvania State University, Hershey, PA, USA.

Publikováno v: Therapeutic advances in hematology [Ther Adv Hematol] 2023 May 03; Vol. 14, pp. 20406207231170708. Date of Electronic Publication: 2023 May 03 (Print Publication: 2023).