Recent advances in methodology for clinical trials in small populations: the InSPiRe project

Autor: Friede, T., Posch, M., Zohar, S., Alberti, C., Benda, N., Comets, E., Day, S., Dmitrenko, A., Graf, A., Günhan, B. K., Hee, S. W., Lentz, F., Madan, J., Miller, F., Ondra, T., Pearce, M., Röver, C., Tournazi, A., Unkel, S., Ursino, M., Wassmer, G., Stallard, N.

Publikováno v: Orphanet Journal of Rare Diseases, 13:136, 2018

Where there are a limited number of patients, such as in a rare disease, clinical trials in these small populations present several challenges, including statistical issues. This led to an EU FP7 call for proposals in 2013. One of the three projects

Externí odkaz: http://arxiv.org/abs/1811.02504

PharmML in Action: an Interoperable Language for Modeling and Simulation.

Autor: Bizzotto, R¹, Comets, E^2,3 emmanuelle.comets@inserm.fr, Smith, G⁴, Yvon, F⁵, Kristensen, NR⁶, Swat, MJ^5,7

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology. Oct2017, Vol. 6 Issue 10, p651-665. 15p.

Population kinetics of factor VIII in mild hemophilia A patients following desmopressin intravenous administration

Autor: Leven, C., Guillet, B., Foulquier, J. B., Tron, C., Lemaître, F., Verdier, M. C., Carre, J. L., Bellissant, E., Comets, E.

Publikováno v: Fundamental & Clinical Pharmacology
Fundamental & Clinical Pharmacology, 2017, 31, pp.18--18
Fundamental and Clinical Pharmacology
Fundamental and Clinical Pharmacology, Wiley, 2017, 31, pp.18--18

International audience; Special Issue: SI Meeting Abstract: CO - 062

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c75d6b72f118537760edacb927299b8d
https://univ-rennes.hal.science/hal-01518339

Nonparametric analysis of the absorption profile of octreotide in rabbits from long-acting release formulation OncoLAR

Autor: Comets, E. ^{a, *}, Mentré, F. ^a, Nimmerfall, F. ^b, Kawai, R. ^b, Mueller, I. ^b, Marbach, P. ^b, Vonderscher, J. ^b

Publikováno v: In Journal of Controlled Release 1999 59(2):197-205

Comparison of Intrapulmonary and Systemic Pharmacokinetics of Colistin Methanesulfonate (CMS) and Colistin after Aerosol Delivery and Intravenous Administration of CMS in Critically Ill Patients

Autor: Mégarbane, B., Comets, E., Chatelier, D., Lasocki, S., Gauzit, R., Balayn, D., Boisson, Matthieu, Jacobs, Matthieu, Grégoire, Nicolas, Gobin, Patrice, Marchand, S., Couet, William, Mimoz, Olivier

Publikováno v: Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2014, 58 (12), pp.7331-7339. ⟨10.1128/AAC.03510-14⟩

Colistin is an old antibiotic that has recently gained a considerable renewal of interest for the treatment of pulmonary infections due to multidrug-resistant Gram-negative bacteria. Nebulization seems to be a promising form of administration, but co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fafdad8924aac2fe49031fc5350138
https://hal.archives-ouvertes.fr/hal-02477453