Applying intensified design of experiments to mammalian cell culture processes.

Autor: Nold, Verena¹ (AUTHOR) verena.nold@boehringer-ingelheim.com, Junghans, Lisa¹ (AUTHOR) lisa.junghans@boehringer-ingelheim.com, Bisgen, Lorenzo² (AUTHOR), Drerup, Raphael¹ (AUTHOR), Presser, Beate¹ (AUTHOR), Gorr, Ingo¹ (AUTHOR), Schwab, Thomas¹ (AUTHOR), Knapp, Bettina¹ (AUTHOR), Wieschalka, Stefan¹ (AUTHOR)

Publikováno v: Engineering in Life Sciences. Dec2022, Vol. 22 Issue 12, p784-795. 12p.

Development and qualification of 3 L scale-down model for large scale vaccine process on Vero cell culture using microcarriers.

Autor: Huang R; Bioprocess Drug Substance Commercialization, Merck & Co., Inc., West Point, Pennsylvania, USA., Wang K; Bioprocess Drug Substance Commercialization, Merck & Co., Inc., West Point, Pennsylvania, USA., Flamm MH; Applied Mathematics and Modeling, Merck & Co., Inc., West Point, Pennsylvania, USA., Vazquez J; Center of Mathematical Sciences, Merck & Co., Inc., West Point, Pennsylvania, USA., Gercke C; Bioprocess Drug Substance Commercialization, Merck & Co., Inc., West Point, Pennsylvania, USA., Ton C; Vaccine Process Development, Merck & Co., Inc., West Point, Pennsylvania, USA., Whitmer T; Bioprocess Drug Substance Commercialization, Merck & Co., Inc., West Point, Pennsylvania, USA., Mathis PK; Global Quality Large Molecule Analytical Sciences, Merck & Co., Inc., West Point, Pennsylvania, USA., Ploeger KJM; Bioprocess Drug Substance Commercialization, Merck & Co., Inc., West Point, Pennsylvania, USA., Rameez S; Bioprocess Drug Substance Commercialization, Merck & Co., Inc., West Point, Pennsylvania, USA.

Publikováno v: Biotechnology and bioengineering [Biotechnol Bioeng] 2024 Nov; Vol. 121 (11), pp. 3402-3414. Date of Electronic Publication: 2024 Jul 11.

Leveraging high-throughput technology to accelerate the time to clinic: A case study of a mAb.

Autor: Siva, Sethu¹, Zhang, An², Koepf, Edward¹ edward.koepf@biogen.com, Conley, Lynn¹, Cecchini, Doug³, Huang, Yao‐Ming², Kshirsagar, Rashmi⁴, Ryll, Thomas⁴

Publikováno v: Engineering in Life Sciences. Mar2016, Vol. 16 Issue 2, p143-151. 9p.

Biochemical and Computational Studies of the Interaction between a Glucosamine Derivative, NAPA, and the IKK α Kinase.

Autor: Lopreiato, Mariangela^1,2 (AUTHOR) mariangela.lopreiato@gmail.com, Di Cristofano, Samuele³ (AUTHOR) dicristofano.1665448@studenti.uniroma1.it, Cocchiola, Rossana^1,4 (AUTHOR) rossana.cocchiola@gmail.com, Mariano, Alessia¹ (AUTHOR) alessia.mariano@uniroma1.it, Guerrizio, Libera¹ (AUTHOR) liberagtab3@gmail.com, Scandurra, Roberto¹ (AUTHOR) roberto.scandurra@fondazione.uniroma1.it, Mosca, Luciana¹ (AUTHOR) luciana.mosca@uniroma1.it, Raimondo, Domenico³ (AUTHOR) domenico.raimondo@uniroma1.it, d'Abusco, Anna Scotto¹ (AUTHOR) domenico.raimondo@uniroma1.it, Lymperopoulos, Anastasios (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Feb2021, Vol. 22 Issue 4, p1643-1643. 1p.

Inhibitory-κB Kinase (IKK) α and Nuclear Factor-κB (NFκB)-Inducing Kinase (NIK) as Anti-Cancer Drug Targets.

Autor: Paul, Andrew¹ a.paul@strath.ac.uk, Edwards, Joanne² Joanne.Edwards@glasgow.ac.uk, Pepper, Christopher³ C.Pepper@bsms.ac.uk, Mackay, Simon¹

Publikováno v: Cells (2073-4409). Oct2018, Vol. 7 Issue 10, p176. 1p.