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Tissue nano-transfection of antimicrobial genes drives bacterial biofilm killing in wounds and is potentially mediated by extracellular vesicles.

Autor: Cuellar-Gaviria TZ; Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA., Rincon-Benavides MA; Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA; Biophysics Program, The Ohio State University, Columbus, OH 43210, USA., Topsakal HNH; Istanbul Atlas University (Turkiye), The Ohio State University, Columbus, OH 43210, USA., Salazar-Puerta AI; Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA., Jaramillo-Garrido S; Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA., Kordowski M; Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA; Biophysics Program, The Ohio State University, Columbus, OH 43210, USA., Vasquez-Martinez CA; Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA; CONACYT-Faculty of Medicine, Benito Juarez Autonomous University of Oxaca (Mexico), The Ohio State University, Columbus, OH 43210, USA., Nguyen KT; William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA., Rima XY; William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA., Rana PSJB; Department of Microbiology, The Ohio State University, Columbus, OH 43210, USA; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA., Combita-Heredia O; Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA., Deng B; Center for Electron Microscopy and Analysis (CEMAS), The Ohio State University, Columbus, OH 43210, USA., Dathathreya K; Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA., McComb DW; Center for Electron Microscopy and Analysis (CEMAS), The Ohio State University, Columbus, OH 43210, USA; Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, USA., Reategui E; William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210, USA; Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA., Wozniak D; Department of Microbiology, The Ohio State University, Columbus, OH 43210, USA; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA; Infectious Disease Institute, The Ohio State University, Columbus, OH 43210, USA., Higuita-Castro N; Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA; Biophysics Program, The Ohio State University, Columbus, OH 43210, USA; Department of Neurological Surgery, The Ohio State University, Columbus, OH 43210, USA; Gene Therapy Institute, The Ohio State University, Columbus, OH 43210, USA., Gallego-Perez D; Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA; Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA; Biophysics Program, The Ohio State University, Columbus, OH 43210, USA; Gene Therapy Institute, The Ohio State University, Columbus, OH 43210, USA; Department of Surgery, The Ohio State University, Columbus, OH 43210, USA. Electronic address: gallegoperez@osumc.edu.

Publikováno v: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2024 Nov 02. Date of Electronic Publication: 2024 Nov 02.