Zobrazeno 1 - 10
of 723
pro vyhledávání: '"Combinatorial therapy"'
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-32 (2024)
Abstract Glioblastoma (GBM) is a fatal brain tumour that is traditionally diagnosed based on histological features. Recent molecular profiling studies have reshaped the World Health Organization approach in the classification of central nervous syste
Externí odkaz:
https://doaj.org/article/1092b78e14704562b6d3db5fea16aa2d
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Chimeric antigen receptor T (CAR-T) cell therapy has been a milestone breakthrough in the treatment of hematological malignancies, offering an effective therapeutic option for multi-line therapy-refractory patients. So far, abundant CAR-T products ha
Externí odkaz:
https://doaj.org/article/a3d932b8f4e149cc8e45f736c1b634c0
Autor:
Lindokuhle Cindy Nene, Heidi Abrahamse
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 1077-1097 (2024)
Cancer remains one of the diseases with the highest incidence and mortality globally. Conventional treatment modalities have demonstrated threatening drawbacks including invasiveness, non-controllability, and development of resistance for some, inclu
Externí odkaz:
https://doaj.org/article/20fa393db4f84561b4e3d8ad9674c5e3
Publikováno v:
Food Chemistry Advances, Vol 4, Iss , Pp 100670- (2024)
There is increasing folkloric evidence of the use of the Spondias mombin plant in the management of various illnesses including diabetes. This could be attributed to its anti-hyperglycemic activity. In the same manner, combinatorial therapy has been
Externí odkaz:
https://doaj.org/article/d86b3c7d17784050b1c6e66fa114d384
Publikováno v:
Cancer Reports, Vol 7, Iss 5, Pp n/a-n/a (2024)
Abstract Background Statins, frequently prescribed medications, work by inhibiting the rate‐limiting enzyme HMG‐CoA reductase (HMGCR) in the mevalonate pathway to reduce cholesterol levels. Due to their multifaceted benefits, statins are being ad
Externí odkaz:
https://doaj.org/article/33a0cbdfe84b4227bd4c874c3678eb3d
Autor:
Claudia Kalla, German Ott, Francesca Finotello, Karolina Niewola-Staszkowska, Giusy Di Conza, Michael Lahn, Lars van der Veen, Julia Schüler, Roger Falkenstern-Ge, Joanna Kopecka, Chiara Riganti
Publikováno v:
Translational Oncology, Vol 43, Iss , Pp 101857- (2024)
Targeting aberrantly expressed kinases in malignant pleural mesothelioma (MPM) is a promising therapeutic strategy. We here investigated the effect of the novel and highly selective Phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib (IOA
Externí odkaz:
https://doaj.org/article/29e97e2677864d378073466d49ffbb29
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7509 (2024)
Dendritic cell (DC) cancer vaccines are a promising therapeutic approach, leveraging the immune system to fight tumors. These vaccines utilize DCs’ ability to present tumor-associated antigens to T cells, triggering a robust immune response. DC vac
Externí odkaz:
https://doaj.org/article/98f9abfe23704a199e5737d03dc814ea
Autor:
Seyed Sadegh Eslami, Davod Jafari, Abbas Ghotaslou, Moein Amoupour, Amir Asri Kojabad, Rasool Jafari, Navid Mousazadeh, Parastoo Tarighi, Majid Sadeghizadeh
Publikováno v:
Advanced Pharmaceutical Bulletin, Vol 13, Iss 3, Pp 539-550 (2023)
Purpose: Chemotherapy drugs used to treat lung cancer are associated with drug resistance and severe side effects. There have been rising demands for new therapeutic candidates and novel approaches, including combination therapy. Here, we aimed to in
Externí odkaz:
https://doaj.org/article/ab7ce32c3b9641158914b3954253cbd6
Publikováno v:
Metabolites, Vol 14, Iss 6, p 325 (2024)
Epigenetic and metabolic reprogramming alterations are two important features of tumors, and their reversible, spatial, and temporal regulation is a distinctive hallmark of carcinogenesis. Epigenetics, which focuses on gene regulatory mechanisms beyo
Externí odkaz:
https://doaj.org/article/bb22124ba9624d288d57683d3c8d479d
Publikováno v:
Cancers, Vol 16, Iss 11, p 2012 (2024)
Triple-negative breast cancer (TNBC), lacking specific receptors found in other breast cancer subtypes, poses significant treatment challenges due to limited therapeutic options. Therefore, it is necessary to develop novel treatment approaches for TN
Externí odkaz:
https://doaj.org/article/d677120d2b984c168a71896fe135b92c