Discovery of (2S)-8-[(3R)-3-methylmorpholin-4-yl]-1-(3-methyl-2-oxobutyl)-2-(trifluoromethyl)-3,4-dihydro-2H-pyrimido[1,2-a]pyrimidin-6-one: a novel potent and selective inhibitor of Vps34 for the treatment of solid tumors.

Autor: Pasquier B; Oncology Drug Discovery, ‡Drug Disposition and Safety, §Structure Design Informatics and Structural Biology, ∥Pharmaceutical Sciences Operations, ⊥Protein Production, and #Global Biotherapeutic, Sanofi , 13 Quai Jules Guesde, 94403 Vitry-sur-Seine, France., El-Ahmad Y, Filoche-Rommé B, Dureuil C, Fassy F, Abecassis PY, Mathieu M, Bertrand T, Benard T, Barrière C, El Batti S, Letallec JP, Sonnefraud V, Brollo M, Delbarre L, Loyau V, Pilorge F, Bertin L, Richepin P, Arigon J, Labrosse JR, Clément J, Durand F, Combet R, Perraut P, Leroy V, Gay F, Lefrançois D, Bretin F, Marquette JP, Michot N, Caron A, Castell C, Schio L, McCort G, Goulaouic H, Garcia-Echeverria C, Ronan B

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2015 Jan 08; Vol. 58 (1), pp. 376-400. Date of Electronic Publication: 2014 Nov 26.

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Paddle-wheel mechanism in doped succinonitrile–glutaronitrile plastic electrolyte: a joint magnetic resonance, dielectric, and viscosimetry study of Li ion translational and molecular reorientational dynamics.

Autor: Lansab, S., Grabe, B., Böhmer, R.

Publikováno v: Physical Chemistry Chemical Physics (PCCP); 4/7/2023, Vol. 25 Issue 13, p9382-9393, 12p

Clinical Pharmacokinetics of Radiopharmaceuticals from SPECT/CT Image Acquisition by Contouring in Patients with Gastroenteropancreatic Neuroendocrine Tumors: Lu-177 DOTATATE (Lutathera ^® ) Case.

Autor: Barakat A; Pharmacokinetics and Pharmacometrics Department, School of Pharmacy, UFR Pharmacie, Montpellier University, 15 Avenue Charles Flahault, 34000, Montpellier, France.; Probabilities and Statistics Department, Institut Montpelliérain Alexander Grothendieck (IMAG), CNRS, UMR 5149, Inria, Montpellier University, Montpellier, France.; Nuclear Medicine Department, Montpellier Cancer Institute, Montpellier University, Montpellier, France., Santoro L; Nuclear Medicine Department, Montpellier Cancer Institute, Montpellier University, Montpellier, France.; Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Montpellier University, Montpellier, France., Vivien M; Biostatistics, Informatics and pharmaceutical physic Laboratory, School of Pharmacy, UFR Pharmacie, Montpellier University, 15 Av. Ch. Flahault, 34000, Montpellier, France.; Institute of Functional Genomic (IGF)- UMR 5203, INSERM U1191, Montpellier, France., Kotzki PO; Nuclear Medicine Department, Montpellier Cancer Institute, Montpellier University, Montpellier, France.; Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Montpellier University, Montpellier, France., Deshayes E; Nuclear Medicine Department, Montpellier Cancer Institute, Montpellier University, Montpellier, France.; Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Montpellier University, Montpellier, France., Khier S; Pharmacokinetics and Pharmacometrics Department, School of Pharmacy, UFR Pharmacie, Montpellier University, 15 Avenue Charles Flahault, 34000, Montpellier, France. sonia.khier@umontpellier.fr.; Probabilities and Statistics Department, Institut Montpelliérain Alexander Grothendieck (IMAG), CNRS, UMR 5149, Inria, Montpellier University, Montpellier, France. sonia.khier@umontpellier.fr.

Publikováno v: European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2023 Jul; Vol. 48 (4), pp. 329-339. Date of Electronic Publication: 2023 May 15.

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