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Akademický článek

Identification and pharmacological profile of SPP1, a potent, functionally selective and brain penetrant agonist at muscarinic M 1 receptors.

Autor: Broad LM; Eli Lilly and Company, Lilly Research Centre, Windlesham, Surrey, UK., Sanger HE; Eli Lilly and Company, Lilly Research Centre, Windlesham, Surrey, UK., Mogg AJ; Eli Lilly and Company, Lilly Research Centre, Windlesham, Surrey, UK., Colvin EM; Eli Lilly and Company, Lilly Research Centre, Windlesham, Surrey, UK., Zwart R; Eli Lilly and Company, Lilly Research Centre, Windlesham, Surrey, UK., Evans DA; Eli Lilly and Company, Lilly Research Centre, Windlesham, Surrey, UK., Pasqui F; Eli Lilly and Company, Lilly Research Centre, Windlesham, Surrey, UK., Sher E; Eli Lilly and Company, Lilly Research Centre, Windlesham, Surrey, UK., Wishart GN; Eli Lilly and Company, Lilly Research Centre, Windlesham, Surrey, UK., Barth VN; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Felder CC; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Goldsmith PJ; Eli Lilly and Company, Lilly Research Centre, Windlesham, Surrey, UK.

Publikováno v: British journal of pharmacology [Br J Pharmacol] 2019 Jan; Vol. 176 (1), pp. 110-126. Date of Electronic Publication: 2018 Nov 16.

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Vybrat výsledek číslo 2 2

Akademický článek

In Vitro Pharmacological Characterization and In Vivo Validation of LSN3172176 a Novel M1 Selective Muscarinic Receptor Agonist Tracer Molecule for Positron Emission Tomography.

Autor: Mogg AJ; Eli Lilly & Co. Ltd., Lilly Research Centre, Windlesham, Surrey, United Kingdom (A.J.M., H.E.S., M.G.C., A.S., E.M.C., P.J.G., L.M.B.) and Eli Lilly & Co. Ltd., Lilly Corporate Center, Indianapolis, Indiana (T.E., M.J., R.W., H.X., D.S., D.G., C.J., M.P.J., C.C.F., V.N.B.) mogg_adrian@lilly.com., Eessalu T; Eli Lilly & Co. Ltd., Lilly Research Centre, Windlesham, Surrey, United Kingdom (A.J.M., H.E.S., M.G.C., A.S., E.M.C., P.J.G., L.M.B.) and Eli Lilly & Co. Ltd., Lilly Corporate Center, Indianapolis, Indiana (T.E., M.J., R.W., H.X., D.S., D.G., C.J., M.P.J., C.C.F., V.N.B.)., Johnson M; Eli Lilly & Co. Ltd., Lilly Research Centre, Windlesham, Surrey, United Kingdom (A.J.M., H.E.S., M.G.C., A.S., E.M.C., P.J.G., L.M.B.) and Eli Lilly & Co. Ltd., Lilly Corporate Center, Indianapolis, Indiana (T.E., M.J., R.W., H.X., D.S., D.G., C.J., M.P.J., C.C.F., V.N.B.)., Wright R; Eli Lilly & Co. Ltd., Lilly Research Centre, Windlesham, Surrey, United Kingdom (A.J.M., H.E.S., M.G.C., A.S., E.M.C., P.J.G., L.M.B.) and Eli Lilly & Co. Ltd., Lilly Corporate Center, Indianapolis, Indiana (T.E., M.J., R.W., H.X., D.S., D.G., C.J., M.P.J., C.C.F., V.N.B.)., Sanger HE; Eli Lilly & Co. Ltd., Lilly Research Centre, Windlesham, Surrey, United Kingdom (A.J.M., H.E.S., M.G.C., A.S., E.M.C., P.J.G., L.M.B.) and Eli Lilly & Co. Ltd., Lilly Corporate Center, Indianapolis, Indiana (T.E., M.J., R.W., H.X., D.S., D.G., C.J., M.P.J., C.C.F., V.N.B.)., Xiao H; Eli Lilly & Co. Ltd., Lilly Research Centre, Windlesham, Surrey, United Kingdom (A.J.M., H.E.S., M.G.C., A.S., E.M.C., P.J.G., L.M.B.) and Eli Lilly & Co. Ltd., Lilly Corporate Center, Indianapolis, Indiana (T.E., M.J., R.W., H.X., D.S., D.G., C.J., M.P.J., C.C.F., V.N.B.)., Crabtree MG; Eli Lilly & Co. Ltd., Lilly Research Centre, Windlesham, Surrey, United Kingdom (A.J.M., H.E.S., M.G.C., A.S., E.M.C., P.J.G., L.M.B.) and Eli Lilly & Co. Ltd., Lilly Corporate Center, Indianapolis, Indiana (T.E., M.J., R.W., H.X., D.S., D.G., C.J., M.P.J., C.C.F., V.N.B.)., Smith A; Eli Lilly & Co. Ltd., Lilly Research Centre, Windlesham, Surrey, United Kingdom (A.J.M., H.E.S., M.G.C., A.S., E.M.C., P.J.G., L.M.B.) and Eli Lilly & Co. Ltd., Lilly Corporate Center, Indianapolis, Indiana (T.E., M.J., R.W., H.X., D.S., D.G., C.J., M.P.J., C.C.F., V.N.B.)., Colvin EM; Eli Lilly & Co. Ltd., Lilly Research Centre, Windlesham, Surrey, United Kingdom (A.J.M., H.E.S., M.G.C., A.S., E.M.C., P.J.G., L.M.B.) and Eli Lilly & Co. Ltd., Lilly Corporate Center, Indianapolis, Indiana (T.E., M.J., R.W., H.X., D.S., D.G., C.J., M.P.J., C.C.F., V.N.B.)., Schober D; Eli Lilly & Co. Ltd., Lilly Research Centre, Windlesham, Surrey, United Kingdom (A.J.M., H.E.S., M.G.C., A.S., E.M.C., P.J.G., L.M.B.) and Eli Lilly & Co. Ltd., Lilly Corporate Center, Indianapolis, Indiana (T.E., M.J., R.W., H.X., D.S., D.G., C.J., M.P.J., C.C.F., V.N.B.)., Gehlert D; Eli Lilly & Co. Ltd., Lilly Research Centre, Windlesham, Surrey, United Kingdom (A.J.M., H.E.S., M.G.C., A.S., E.M.C., P.J.G., L.M.B.) and Eli Lilly & Co. Ltd., Lilly Corporate Center, Indianapolis, Indiana (T.E., M.J., R.W., H.X., D.S., D.G., C.J., M.P.J., C.C.F., V.N.B.)., Jesudason C; Eli Lilly & Co. Ltd., Lilly Research Centre, Windlesham, Surrey, United Kingdom (A.J.M., H.E.S., M.G.C., A.S., E.M.C., P.J.G., L.M.B.) and Eli Lilly & Co. Ltd., Lilly Corporate Center, Indianapolis, Indiana (T.E., M.J., R.W., H.X., D.S., D.G., C.J., M.P.J., C.C.F., V.N.B.)., Goldsmith PJ; Eli Lilly & Co. Ltd., Lilly Research Centre, Windlesham, Surrey, United Kingdom (A.J.M., H.E.S., M.G.C., A.S., E.M.C., P.J.G., L.M.B.) and Eli Lilly & Co. Ltd., Lilly Corporate Center, Indianapolis, Indiana (T.E., M.J., R.W., H.X., D.S., D.G., C.J., M.P.J., C.C.F., V.N.B.)., Johnson MP; Eli Lilly & Co. Ltd., Lilly Research Centre, Windlesham, Surrey, United Kingdom (A.J.M., H.E.S., M.G.C., A.S., E.M.C., P.J.G., L.M.B.) and Eli Lilly & Co. Ltd., Lilly Corporate Center, Indianapolis, Indiana (T.E., M.J., R.W., H.X., D.S., D.G., C.J., M.P.J., C.C.F., V.N.B.)., Felder CC; Eli Lilly & Co. Ltd., Lilly Research Centre, Windlesham, Surrey, United Kingdom (A.J.M., H.E.S., M.G.C., A.S., E.M.C., P.J.G., L.M.B.) and Eli Lilly & Co. Ltd., Lilly Corporate Center, Indianapolis, Indiana (T.E., M.J., R.W., H.X., D.S., D.G., C.J., M.P.J., C.C.F., V.N.B.)., Barth VN; Eli Lilly & Co. Ltd., Lilly Research Centre, Windlesham, Surrey, United Kingdom (A.J.M., H.E.S., M.G.C., A.S., E.M.C., P.J.G., L.M.B.) and Eli Lilly & Co. Ltd., Lilly Corporate Center, Indianapolis, Indiana (T.E., M.J., R.W., H.X., D.S., D.G., C.J., M.P.J., C.C.F., V.N.B.)., Broad LM; Eli Lilly & Co. Ltd., Lilly Research Centre, Windlesham, Surrey, United Kingdom (A.J.M., H.E.S., M.G.C., A.S., E.M.C., P.J.G., L.M.B.) and Eli Lilly & Co. Ltd., Lilly Corporate Center, Indianapolis, Indiana (T.E., M.J., R.W., H.X., D.S., D.G., C.J., M.P.J., C.C.F., V.N.B.).

Publikováno v: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2018 Jun; Vol. 365 (3), pp. 602-613. Date of Electronic Publication: 2018 Apr 11.

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Vybrat výsledek číslo 3 3

Akademický článek

Activation of Muscarinic M1 Acetylcholine Receptors Induces Long-Term Potentiation in the Hippocampus.

Autor: Dennis SH; Neuroscience, Eli Lilly & Company, Windlesham, Surrey GU20 6PH, UK., Pasqui F; Neuroscience, Eli Lilly & Company, Windlesham, Surrey GU20 6PH, UK., Colvin EM; Neuroscience, Eli Lilly & Company, Windlesham, Surrey GU20 6PH, UK., Sanger H; Neuroscience, Eli Lilly & Company, Windlesham, Surrey GU20 6PH, UK., Mogg AJ; Neuroscience, Eli Lilly & Company, Windlesham, Surrey GU20 6PH, UK., Felder CC; Neuroscience, Eli Lilly & Company, Indianapolis, IN 46285, USA., Broad LM; Neuroscience, Eli Lilly & Company, Windlesham, Surrey GU20 6PH, UK., Fitzjohn SM; Neuroscience, Eli Lilly & Company, Windlesham, Surrey GU20 6PH, UK School of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, UK., Isaac JT; Neuroscience, Eli Lilly & Company, Windlesham, Surrey GU20 6PH, UK., Mellor JR; School of Physiology and Pharmacology, University of Bristol, Bristol BS8 1TD, UK.

Publikováno v: Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2016 Jan; Vol. 26 (1), pp. 414-26. Date of Electronic Publication: 2015 Oct 15.

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Vybrat výsledek číslo 4 4

Akademický článek

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Vybrat výsledek číslo 5 5

Akademický článek

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Vybrat výsledek číslo 6 6

Akademický článek

The potential of muscarinic M1 and M4 receptor activators for the treatment of cognitive impairment associated with schizophrenia.

Autor: Yohn, Samantha E., Harvey, Phillip D., Brannan, Stephen K., Horan, William P.

Publikováno v: Frontiers in Psychiatry; 2024, p1-15, 15p

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Vybrat výsledek číslo 7 7

Akademický článek

Pharmacological characterisation of ligand- and voltage-gated ion channels expressed in human iPSC-derived forebrain neurons.

Autor: Dage JL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, 46285, USA., Colvin EM, Fouillet A, Langron E, Roell WC, Li J, Mathur SX, Mogg AJ, Schmitt MG, Felder CC, Merchant KM, Isaac J, Broad LM, Sher E, Ursu D

Publikováno v: Psychopharmacology [Psychopharmacology (Berl)] 2014 Mar; Vol. 231 (6), pp. 1105-24. Date of Electronic Publication: 2014 Jan 16.

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Vybrat výsledek číslo 8 8

Akademický článek

The effects of kindling during pregnancy on long-term potentiation (LTP) induction and M1 muscarinic acetylcholine receptors in male rat offspring.

Autor: Pourmotabbed, Ali¹ (AUTHOR), Naghizadeh, Razieh¹ (AUTHOR), Moradpour, Farshad² (AUTHOR), Veisi, Mozhgan¹ (AUTHOR), Nedaei, Seyed¹ (AUTHOR), Zarei, Fatemeh¹ (AUTHOR), Salimi, Zahra¹ (AUTHOR)

Publikováno v: Research in Pharmaceutical Sciences. Jun2023, Vol. 18 Issue 3, p326-335. 10p.

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Vybrat výsledek číslo 9 9

Akademický článek

Pharmacological profiling of native group II metabotropic glutamate receptors in primary cortical neuronal cultures using a FLIPR.

Autor: Sanger H; Neuroscience Research Division, Lilly Research Centre, Eli Lilly & Co. Ltd., Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK., Hanna L, Colvin EM, Grubisha O, Ursu D, Heinz BA, Findlay JD, Vivier RG, Sher E, Lodge D, Monn JA, Broad LM

Publikováno v: Neuropharmacology [Neuropharmacology] 2013 Mar; Vol. 66, pp. 264-73. Date of Electronic Publication: 2012 May 30.

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Vybrat výsledek číslo 10 10

Akademický článek

In vitro characterisation of the novel positive allosteric modulators of the mGlu₅ receptor, LSN2463359 and LSN2814617, and their effects on sleep architecture and operant responding in the rat.