Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Colton M Tom"'
Autor:
Emily Machiela, Ritika Jeloka, Nicholas S. Caron, Shagun Mehta, Mandi E. Schmidt, Helen J. E. Baddeley, Colton M. Tom, Nalini Polturi, Yuanyun Xie, Virginia B. Mattis, Michael R. Hayden, Amber L. Southwell
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Huntington disease (HD) is a fatal, inherited neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene. While mutant HTT is present ubiquitously throughout life, HD onset typically occurs in mid-life. Oxidative damage accumulates
Externí odkaz:
https://doaj.org/article/927e14de01344da3b997cbcf2b24e178
Autor:
Veronica J. Garcia, David J. Rushton, Colton M. Tom, Nicholas D. Allen, Paul J. Kemp, Clive N. Svendsen, Virginia B. Mattis
Publikováno v:
Frontiers in Neuroscience, Vol 13 (2019)
In Huntington’s disease (HD), while the ubiquitously expressed mutant Huntingtin (mtHTT) protein primarily compromises striatal and cortical neurons, glia also undergo disease-contributing alterations. Existing HD models using human induced pluripo
Externí odkaz:
https://doaj.org/article/7009091143fd4c03ba857bb05ef20179
Autor:
Shagun R. Mehta, Colton M. Tom, Yizhou Wang, Catherine Bresee, David Rushton, Pranav P. Mathkar, Jie Tang, Virginia B. Mattis
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 1081-1096.e6 (2018)
Summary: Huntington’s disease (HD) is a neurodegenerative disease caused by an expanded CAG repeat in the Huntingtin (HTT) gene. Induced pluripotent stem cell (iPSC) models of HD provide an opportunity to study the mechanisms underlying disease pat
Externí odkaz:
https://doaj.org/article/9e7eadc0a07448b88c3fc2fa4a4c5afb
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Huntington's disease (HD) is a devastating neurodegenerative disorder caused by a polyglutamine (polyQ) expansion in exon 1 of the Huntingtin (HTT) gene. We have previously demonstrated that spliceosome-mediated trans-splicing is a viable molecular s
Externí odkaz:
https://doaj.org/article/b49bc7791a084262a73dd49edb74a1f9
Autor:
Helen J E Baddeley, Nalini Polturi, Mandi E. Schmidt, Yuanyun Xie, Nicholas S. Caron, Colton M Tom, Ritika Jeloka, Emily Machiela, Shagun Mehta, Amber L. Southwell, Virginia B. Mattis, Michael R. Hayden
Publikováno v:
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, Vol 12 (2020)
Frontiers in Aging Neuroscience, Vol 12 (2020)
Huntington disease (HD) is a fatal, inherited neurodegenerative disorder caused by a mutation in the huntingtin (HTT) gene. While mutant HTT is present ubiquitously throughout life, HD onset typically occurs in mid-life. Oxidative damage accumulates
Autor:
Joshua J. Breunig, Virginia B. Mattis, Gi-Bum Kim, Leslie Garcia, Steve E. Savinoff, David Saxon, George Lawless, Brandon Shelley, Hannah Park, Naomi Kobritz, Colton M Tom, Noell Cho, Aslam Abbasi Akhtar, Genevieve Gowing, Clive N. Svendsen
Publikováno v:
Stem Cell Reports
Summary Trophic factor delivery to the brain using stem cell-derived neural progenitors is a powerful way to bypass the blood-brain barrier. Protection of diseased neurons using this technology is a promising therapy for neurodegenerative diseases. G
Autor:
Mandi E. Schmidt, Nalini Potluri, Virginia B. Mattis, Colton M Tom, Shagun Mehta, Ritika Jeloka, Nicholas S. Caron, Emily Machiela, Michael R. Hayden, Yuanyun Xie, Amber L. Southwell
Huntington disease (HD) is a fatal, inherited neurodegenerative disorder caused by a mutation in huntingtin (HTT). While mutant HTT is present ubiquitously throughout life, HD onset typically occurs in mid-life. Oxidative damage accumulates in the ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a793f01a3ebe1b8a8e40aebcbe4492ce
Publikováno v:
Journal of Huntington's Disease
Background Huntington's disease (HD) is an inherited neurodegenerative disease and is characterized by atrophy of certain regions of the brain in a progressive manner. HD patients experience behavioral changes and uncontrolled movements which can be
Autor:
Julia A. Kaye, Malcolm Casale, Ping H Wang, Steven Finkbeiner, Yumay Chen, Ryan G. Lim, Ernest Fraenkel, Min Wu, Alvin R. King, Leslie M. Thompson, Jennifer Stocksdale, Marcy E. MacDonald, Virginia B. Mattis, Nicolas Arbez, Tamara Ratovitski, Clive N. Svendsen, Christopher A. Ross, Amanda J. Kedaigle, James F. Gusella, Colton M Tom, Ranjit Singh Atwal, Sergey S Akimov
Publikováno v:
Human Molecular Genetics
Altered cellular metabolism is believed to be an important contributor to pathogenesis of the neurodegenerative disorder Huntington’s disease (HD). Research has primarily focused on mitochondrial toxicity, which can cause death of the vulnerable st
Publikováno v:
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 11 (2017)
Frontiers in Neuroscience, Vol 11 (2017)
Huntington's disease (HD) is a devastating neurodegenerative disorder caused by a polyglutamine (polyQ) expansion in exon 1 of the Huntingtin (HTT) gene. We have previously demonstrated that spliceosome-mediated trans-splicing is a viable molecular s