Zobrazeno 1 - 2
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pro vyhledávání: '"Colton J. Hernandez"'
Autor:
Minal Engavale, Colton J. Hernandez, Angelica Infante, Tanya LeRoith, Elliott Radovan, Lauryn Evans, Johanna Villarreal, Christopher M. Reilly, R. Bryan Sutton, Peter A. Keyel
Publikováno v:
bioRxiv
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease caused by environmental factors and loss of key proteins. One such protein is a serum endonuclease secreted by macrophages and dendritic cells, Dnase1L3. Loss of Dnase1L3 causes pedia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937d5f8772081ec4326a9660e59b4b30
https://doi.org/10.1101/2023.04.17.537232
https://doi.org/10.1101/2023.04.17.537232
Publikováno v:
The Journal of Immunology. 204:219.18-219.18
A hallmark symptom of SLE is elevated autoantibodies, especially anti-dsDNA antibodies in multiple organs and tissues. Deficiency of Dnase1L3, a serum endonuclease, allows the accumulation of self-DNA leading to autoantibody generation. The source of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ccb46af345a6414dac8363cd9d2adbc
https://doi.org/10.4049/jimmunol.204.supp.219.18
https://doi.org/10.4049/jimmunol.204.supp.219.18
