Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Colton J. F. Watson"'
Autor:
Kennedy C. Whitley, Sophie I. Hamstra, Ryan W. Baranowski, Colton J. F. Watson, Rebecca E. K. MacPherson, Adam J. MacNeil, Brian D. Roy, Rene Vandenboom, Val A. Fajardo
Publikováno v:
Physiological Reports, Vol 8, Iss 14, Pp n/a-n/a (2020)
Abstract Calcineurin is a Ca2+‐dependent serine/threonine phosphatase that dephosphorylates nuclear factor of activated T cells (NFAT), allowing for NFAT entry into the nucleus. In skeletal muscle, calcineurin signaling and NFAT activation increase
Externí odkaz:
https://doaj.org/article/6689be618e60477c9bb477efb50dd6cb
Amplified detection of nucleic acids and proteins using an isothermal proximity CRISPR Cas12a assay†
Publikováno v:
Chemical Science
Herein, we describe an isothermal proximity CRISPR Cas12a assay that harnesses the target-induced indiscrimitive single-stranded DNase activity of Cas12a for the quantitative profiling of gene expression at the mRNA level and detection of proteins wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f723ea9e5302598af953e20a92d8a785
http://europepmc.org/articles/PMC8179305
http://europepmc.org/articles/PMC8179305
Autor:
Nigel Kurgan, Adam J. MacNeil, Sophie I. Hamstra, Liqun Qiu, Rebecca E. K. MacPherson, Colton J. F. Watson, Holt N. Messner, Brian D. Roy, Ryan W. Baranowski, Val A. Fajardo
Publikováno v:
Experimental Physiology. 105:666-675
NEW FINDINGS What is the central question of this study? Inhibition of glycogen synthase kinase-3 (GSK3) has been shown to improve cardiac SERCA2a function. Lithium can inhibit GSK3, but therapeutic doses used in treating bipolar disorder can have to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf3407c6159811b4bdde8df67f55b25
https://doi.org/10.1113/ep088061
https://doi.org/10.1113/ep088061
Autor:
Val A. Fajardo, Robert W. E. Crozier, Michael Yousef, Adam J. MacNeil, Colton J. F. Watson, Kelly Bruton, Melissa M. Rouillard, Aindriu R. R. Maguire
Publikováno v:
Journal of Leukocyte Biology. 107:649-661
Mast cells drive the inappropriate immune response characteristic of allergic inflammatory disorders via release of pro-inflammatory mediators in response to environmental cues detected by the IgE-FcεRI complex. The role of TGF-β-activated kinase 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913fe807fa8c999b256a19d3d559eb92
https://doi.org/10.1002/jlb.2a0220-401rrr
https://doi.org/10.1002/jlb.2a0220-401rrr
Autor:
Emily N. Copeland, Colton J. F. Watson, Kennedy C. Whitley, Bradley J. Baranowski, Nigel Kurgan, Adam J. MacNeil, Rebecca E. K. MacPherson, Val A. Fajardo, David J. Allison
Publikováno v:
Experimental physiologyREFERENCES. 107(9)
What is the central question in this study? Promoting muscle health with regular aerobic exercise can improve mental health through a kynurenine metabolic pathway: do conditions of muscle disease such as muscular dystrophy negatively influence this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c781cd128d3f38c58878b6cf36ccf040
https://pubmed.ncbi.nlm.nih.gov/35912981
https://pubmed.ncbi.nlm.nih.gov/35912981
Autor:
Colton J. F. Watson, Rene Vandenboom, Brian D. Roy, Ryan W. Baranowski, Adam J. MacNeil, Kennedy C. Whitley, Val A. Fajardo, Rebecca E. K. MacPherson, Sophie I. Hamstra
Publikováno v:
Physiological Reports
Physiological Reports, Vol 8, Iss 14, Pp n/a-n/a (2020)
Physiological Reports, Vol 8, Iss 14, Pp n/a-n/a (2020)
Calcineurin is a Ca2+‐dependent serine/threonine phosphatase that dephosphorylates nuclear factor of activated T cells (NFAT), allowing for NFAT entry into the nucleus. In skeletal muscle, calcineurin signaling and NFAT activation increases the exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666a49dc662789d44b17a4a473064015
https://doi.org/10.14814/phy2.14517
https://doi.org/10.14814/phy2.14517
Autor:
Hayam Mansour, Michael Yousef, Tianyu Dong, Peng Wu, Adam J. MacNeil, Feng Li, Colton J. F. Watson, Ana Sanchez, Hao Hu, Gabriela Matamoros, Guan Alex Wang
Publikováno v:
Analytical chemistry. 92(9)
Miniaturization of nucleic acid tests (NATs) into portable, inexpensive detection platforms may aid disease diagnosis in point-of-care (POC) settings. Colorimetric signals are ideal readouts for portable NATs, and it remains of high demand to develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9c31ecda5183b0e0941de35ed95515
https://pubmed.ncbi.nlm.nih.gov/32259426
https://pubmed.ncbi.nlm.nih.gov/32259426
Autor:
Robert W. E. Crozier, Tylar Boyd, Evangelia Tsiani, Michael Yousef, Adam J. MacNeil, Natalie J. Hicks, Colton J. F. Watson
Publikováno v:
Journal of leukocyte biologyREFERENCES. 107(5)
Mast cells are immune sentinels and a driving force in both normal and pathological contexts of inflammation, with a prominent role in allergic hypersensitivities. Crosslinking of FcεRI by allergen-bound IgE Abs leads to mast cell degranulation, res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db40d045ce1decfa60626f3d6ad55652
https://pubmed.ncbi.nlm.nih.gov/32202360
https://pubmed.ncbi.nlm.nih.gov/32202360
Autor:
Lucas A. Maddalena, Val A. Fajardo, Jeffrey A. Stuart, Adam J. MacNeil, Kelli D. Turner, Catherine Bellissimo, Sandra J. Peters, Fereshteh Moradi, Kirsten N. Bott, Colton J. F. Watson, Paul J. LeBlanc, A. Russell Tupling
Publikováno v:
American journal of physiology. Cell physiology. 317(5)
Calcineurin is a Ca2+/calmodulin (CaM)-dependent phosphatase that plays a critical role in promoting the slow fiber phenotype and myoblast fusion in skeletal muscle, thereby making calcineurin an attractive cellular target for enhancing fatigue resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81f577efeb76d6dc6cb8deb3906a8f52
https://pubmed.ncbi.nlm.nih.gov/31433693
https://pubmed.ncbi.nlm.nih.gov/31433693
Autor:
Colton J. F. Watson, Melissa M. Rouillard, Robert W. E. Crozier, Val A. Fajardo, Adam J. MacNeil
Publikováno v:
The Journal of Immunology. 204:66.1-66.1
Allergic inflammation is an inappropriate immune response, typically triggered by activated mast cells that have been IgE-sensitized to innocuous environmental agents. Allergic inflammatory events can be split into two phases, early and late, initiat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::126b033095437cde68c4ac1f6ad71836
https://doi.org/10.4049/jimmunol.204.supp.66.1
https://doi.org/10.4049/jimmunol.204.supp.66.1