Azetidines Kill Multidrug-Resistant Mycobacterium tuberculosis without Detectable Resistance by Blocking Mycolate Assembly.

Autor: Cui Y; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Lanne A; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Peng X; State Key Laboratory of Respiratory Disease, China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, China., Browne E; Sygnature Discovery, The Discovery Building, BioCity, Pennyfoot Street, Nottingham NG1 1GR, U.K., Bhatt A; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Coltman NJ; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Craven P; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Cox LR; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Cundy NJ; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Dale K; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Feula A; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Frampton J; College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Fung M; Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, 15 Science Park West Avenue NT, Hong Kong SAR., Morton M; ApconiX Ltd, BIOHUB at Alderly Park, Nether Alderly, Cheshire SK10 4TG, U.K., Goff A; Department of Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Falmer BN1 9PX, U.K., Salih M; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Lang X; State Key Laboratory of Respiratory Disease, China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, China., Li X; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K.; State Key Laboratory of Respiratory Disease, China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, China., Moon C; TB Research Group, National Infection Service, Public Health England (UKHSA), Manor Farm Road, Porton, Salisbury SP4 0JG, U.K., Pascoe J; TB Research Group, National Infection Service, Public Health England (UKHSA), Manor Farm Road, Porton, Salisbury SP4 0JG, U.K., Portman V; Sygnature Discovery, The Discovery Building, BioCity, Pennyfoot Street, Nottingham NG1 1GR, U.K., Press C; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Schulz-Utermoehl T; Sygnature Discovery, The Discovery Building, BioCity, Pennyfoot Street, Nottingham NG1 1GR, U.K., Lee S; Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, 15 Science Park West Avenue NT, Hong Kong SAR., Tortorella MD; State Key Laboratory of Respiratory Disease, China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, China.; Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, 15 Science Park West Avenue NT, Hong Kong SAR., Tu Z; State Key Laboratory of Respiratory Disease, China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, China., Underwood ZE; TB Research Group, National Infection Service, Public Health England (UKHSA), Manor Farm Road, Porton, Salisbury SP4 0JG, U.K., Wang C; State Key Laboratory of Respiratory Disease, China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, China., Yoshizawa A; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Zhang T; State Key Laboratory of Respiratory Disease, China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, China., Waddell SJ; Department of Global Health and Infection, Brighton and Sussex Medical School, University of Sussex, Falmer BN1 9PX, U.K., Bacon J; TB Research Group, National Infection Service, Public Health England (UKHSA), Manor Farm Road, Porton, Salisbury SP4 0JG, U.K., Alderwick L; Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K.; Discovery Sciences, Charles River Laboratories, Chesterford Research Park, Saffron Walden CB10 1XL, U.K., Fossey JS; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K., Neagoie C; State Key Laboratory of Respiratory Disease, China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science, 190 Kai Yuan Avenue, Science Park, Guangzhou 510530, China.; Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, 15 Science Park West Avenue NT, Hong Kong SAR.; Visiting Scientist, School of Chemistry, University of Birmingham, Edgbaston, Birmingham, West Midlands B15 2TT, U.K.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Feb 22; Vol. 67 (4), pp. 2529-2548. Date of Electronic Publication: 2024 Feb 08.

Exploring Mitochondrial Energy Metabolism of Single 3D Microtissue Spheroids Using Extracellular Flux Analysis.

Autor: Coltman NJ; School of Biosciences, University of Birmingham., Rochford G; School of Biosciences, University of Birmingham., Hodges NJ; School of Biosciences, University of Birmingham., Ali-Boucetta H; Nanomedicine, Drug Delivery & Nanotoxicology Lab, School of Pharmacy, University of Birmingham., Barlow JP; Mitochondrial Profiling Centre, University of Birmingham; j.p.barlow@bham.ac.uk.

Publikováno v: Journal of visualized experiments : JoVE [J Vis Exp] 2022 Feb 03 (180). Date of Electronic Publication: 2022 Feb 03.

Supramolecular Cylinders Target Bulge Structures in the 5' UTR of the RNA Genome of SARS-CoV-2 and Inhibit Viral Replication.

Autor: Melidis L; Physical Sciences for Health Centre University of Birmingham Edgbaston Birmingham B15 2TT UK., Hill HJ; Institute of Immunology and Immunotherapy University of Birmingham Edgbaston Birmingham B15 2TT UK., Coltman NJ; School of Biosciences University of Birmingham Edgbaston Birmingham B15 2TT UK., Davies SP; Institute of Immunology and Immunotherapy University of Birmingham Edgbaston Birmingham B15 2TT UK., Winczura K; School of Biosciences University of Birmingham Edgbaston Birmingham B15 2TT UK., Chauhan T; Physical Sciences for Health Centre University of Birmingham Edgbaston Birmingham B15 2TT UK., Craig JS; Physical Sciences for Health Centre University of Birmingham Edgbaston Birmingham B15 2TT UK., Garai A; School of Chemistry University of Birmingham Edgbaston Birmingham B15 2TT UK., Hooper CAJ; School of Chemistry University of Birmingham Edgbaston Birmingham B15 2TT UK., Egan RT; School of Chemistry University of Birmingham Edgbaston Birmingham B15 2TT UK., McKeating JA; Nuffield Department of Medicine & Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI) Oxford University Oxford OX3 7BN UK., Hodges NJ; School of Biosciences University of Birmingham Edgbaston Birmingham B15 2TT UK., Stamataki Z; Institute of Immunology and Immunotherapy University of Birmingham Edgbaston Birmingham B15 2TT UK., Grzechnik P; School of Biosciences University of Birmingham Edgbaston Birmingham B15 2TT UK., Hannon MJ; Physical Sciences for Health Centre University of Birmingham Edgbaston Birmingham B15 2TT UK.; School of Chemistry University of Birmingham Edgbaston Birmingham B15 2TT UK.

Publikováno v: Angewandte Chemie (Weinheim an der Bergstrasse, Germany) [Angew Chem Weinheim Bergstr Ger] 2021 Aug 09; Vol. 133 (33), pp. 18292-18299. Date of Electronic Publication: 2021 Jul 09.

Induction of apoptosis in Ogg1-null mouse embryonic fibroblasts by GSH depletion is independent of DNA damage.

Autor: Higgs EB; School of Biosciences, The University of Birmingham, Birmingham, United Kingdom; Department of Pharmacology & Toxicology, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands. Electronic address: EXH648@student.bham.ac.uk., Godschalk R; Department of Pharmacology & Toxicology, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands. Electronic address: R.Godschalk@maastrichtuniversity.nl., Coltman NJ; School of Biosciences, The University of Birmingham, Birmingham, United Kingdom. Electronic address: NJC580@student.bham.ac.uk., Stewart GS; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, United Kingdom. Electronic address: g.s.stewart@bham.ac.uk., van Schooten FJ; Department of Pharmacology & Toxicology, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, Netherlands. Electronic address: F.vanschooten@maastrichtuniversity.nl., Hodges NJ; School of Biosciences, The University of Birmingham, Birmingham, United Kingdom. Electronic address: N.Hodges@bham.ac.uk.

Publikováno v: Toxicology letters [Toxicol Lett] 2020 Oct 10; Vol. 332, pp. 27-35. Date of Electronic Publication: 2020 Jun 22.