Study of the reactivity of aminocyanopyrazoles and evaluation of the mitochondrial reductive function of some products

Autor: Bellili Soumaya, Coltman Nicholas J., Hodges Nikolas J., Allouche Fatma

Publikováno v: Heterocyclic Communications, Vol 28, Iss 1, Pp 11-17 (2022)

This research investigated the general high-throughput synthetic protocol for the accelerated synthesis of functionalized trifluoromethylpyrazolopyrimidines 3 and N-(5-cyano-3-methyl-1-phenyl-1H-pyrazol-4-yl) benzamide 4 from aminocyanopyrazole 1 pre

Externí odkaz: https://doaj.org/article/98b76393163c438aaddaa8696cb6df35

Induction of apoptosis in Ogg1-null mouse embryonic fibroblasts by GSH depletion is independent of DNA damage

Autor: Higgs, Ellen B., Godschalk, Roger, Coltman, Nicholas J., Stewart, Grant S., van Schooten, Frederik-Jan, Hodges, Nikolas J. ^*

Publikováno v: In Toxicology Letters 10 October 2020 332:27-35

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Supramolecular cylinders target bulge structures in the 5' UTR of the RNA genome of SARS-CoV-2 and inhibit viral replication

Autor: Melidis, Lazaros, Davies, Scott, Coltman, Nicholas, Winczura, Kinga, Hodges, Nikolas J., Zania Stamataki, Grzechnik, Pawel, Hannon, Michael J.

Supplementary and raw data on computational aspects of paper Titled;Supramolecular cylinders target bulge structures in the 5’ UTR of the RNA genome of SARS-CoV-2 and inhibit viral replication.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782b923c4d7105d3d0d16be96d24f51e

Supramolecular Cylinders Target Bulge Structures in the 5' UTR of the RNA Genome of SARS-CoV-2 and Inhibit Viral Replication*.

Autor: Melidis L; Physical Sciences for Health Centre, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Hill HJ; Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Coltman NJ; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Davies SP; Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Winczura K; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Chauhan T; Physical Sciences for Health Centre, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Craig JS; Physical Sciences for Health Centre, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Garai A; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Hooper CAJ; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Egan RT; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., McKeating JA; Nuffield Department of Medicine & Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), Oxford University, Oxford, OX3 7BN, UK., Hodges NJ; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Stamataki Z; Institute of Immunology and Immunotherapy, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Grzechnik P; School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Hannon MJ; Physical Sciences for Health Centre, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Aug 09; Vol. 60 (33), pp. 18144-18151. Date of Electronic Publication: 2021 Jul 09.