Drug discovery for heart failure targeting myosin-binding protein C.

Autor: Bunch TA; Department of Cellular & Molecular Medicine, University of Arizona, Tucson, Arizona, USA., Guhathakurta P; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Thompson AR; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Lepak VC; Department of Cellular & Molecular Medicine, University of Arizona, Tucson, Arizona, USA., Carter AL; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA., Thomas JJ; Photonic Pharma LLC, Minneapolis, Minnesota, USA., Thomas DD; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA; Photonic Pharma LLC, Minneapolis, Minnesota, USA. Electronic address: ddt@umn.edu., Colson BA; Department of Cellular & Molecular Medicine, University of Arizona, Tucson, Arizona, USA. Electronic address: bcolson@arizona.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2023 Dec; Vol. 299 (12), pp. 105369. Date of Electronic Publication: 2023 Oct 20.

Fluorescence lifetime-based assay reports structural changes in cardiac muscle mediated by effectors of contractile regulation.

Autor: Dvornikov AV; Department of Cellular and Molecular Medicine, University of Arizona , Tucson, AZ, USA., Bunch TA; Department of Cellular and Molecular Medicine, University of Arizona , Tucson, AZ, USA., Lepak VC; Department of Cellular and Molecular Medicine, University of Arizona , Tucson, AZ, USA., Colson BA; Department of Cellular and Molecular Medicine, University of Arizona , Tucson, AZ, USA.

Publikováno v: The Journal of general physiology [J Gen Physiol] 2023 Mar 06; Vol. 155 (3). Date of Electronic Publication: 2023 Jan 12.

AZD2014, a dual mTOR inhibitor, attenuates cardiac hypertrophy in vitro and in vivo.

Autor: Cha BH; Division of Cardio-Thoracic Surgery, Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, 85724, USA., Jung M; Division of Cardio-Thoracic Surgery, Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, 85724, USA., Kim AS; Division of Cardio-Thoracic Surgery, Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, 85724, USA., Lepak VC; Department of Cellular & Molecular Medicine, University of Arizona College of Medicine, Tucson, AZ, 85724, USA., Colson BA; Department of Cellular & Molecular Medicine, University of Arizona College of Medicine, Tucson, AZ, 85724, USA., Bull DA; Division of Cardio-Thoracic Surgery, Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, 85724, USA., Won Y; Division of Cardio-Thoracic Surgery, Department of Surgery, University of Arizona College of Medicine, Tucson, AZ, 85724, USA. youngwookwon@email.arizona.edu.

Publikováno v: Journal of biological engineering [J Biol Eng] 2021 Oct 21; Vol. 15 (1), pp. 24. Date of Electronic Publication: 2021 Oct 21.

A high-throughput fluorescence lifetime-based assay to detect binding of myosin-binding protein C to F-actin.

Autor: Bunch TA; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ., Lepak VC; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ., Bortz KM; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ., Colson BA; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ.

Publikováno v: The Journal of general physiology [J Gen Physiol] 2021 Mar 01; Vol. 153 (3).

Human cardiac myosin-binding protein C restricts actin structural dynamics in a cooperative and phosphorylation-sensitive manner.

Autor: Bunch TA; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona 85724., Kanassatega RS; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona 85724., Lepak VC; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona 85724., Colson BA; Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona 85724 bcolson@email.arizona.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2019 Nov 01; Vol. 294 (44), pp. 16228-16240. Date of Electronic Publication: 2019 Sep 13.