Výsledky vyhledávání - "Colonic Neoplasms/immunology"

Characterization of a Human—Human Hybridoma Antibody, C-OU1, Directed Against a Colon Tumor-Associated Antigen

Autor: Per Borup-Christensen, Helmuth Haas, Henrik J. Ditzel, John Chemnitz, Karin Erb, Jens C. Jensenius

Publikováno v: Scopus-Elsevier
Erb, K, Borup-Christensen, P, Ditzel, H, Chemnitz, J, Haas, H & Jensenius, J C 1992, ' Characterization of a human-human hybridoma antibody, C-OU1, directed against a colon tumor-associated antigen ', Hybridoma, vol. 11, no. 2, pp. 121-34 . https://doi.org/10.1089/hyb.1992.11.121
Erb, K, Borup-Christensen, P, Ditzel, H, Chemnitz, J, Haas, H D & Jensenius, J C 1992, ' Characterization of a human-human hybridoma antibody, C-OU1, directed against a colon tumor-associated antigen ' Hybridoma, vol. 11, no. 2, pp. 121-34 .

The human hybridoma cell line, B9165, was obtained after fusion of lymphocytes from lymph nodes draining the tumor region in a patient with adenocarcinoma of the colon with the human B-lymphoblastoid cell line WI-L2-729-HF2 (729-HF2). B9165 secretes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74dde0f3238fe81d303a01cd7fcfe0c2
https://doi.org/10.1089/hyb.1992.11.121

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Antigens recognized by two human monoclonal IgM anticolon cancer antibodies, 16.88 and C-OU1 (B9165)

Autor: Jens C. Jensenius, Karin Erb, Henrik J. Ditzel, Per Borup-Christensen, Jens Wæver-Rasmussen

Publikováno v: Erb, K, Ditzel, H, Waever-Rasmussen, J, Borup-Christensen, P & Jensenius, J C 1991, ' Antigens recognized by two human monoclonal IgM anticolon cancer antibodies, 16.88 and C-OU1 (B9165) ', Human antibodies and hybridomas, vol. 2, no. 4, pp. 215-21 .
Erb, K, Ditzel, H, Waever-Rasmussen, J, Borup-Christensen, P & Jensenius, J C 1991, ' Antigens recognized by two human monoclonal IgM anticolon cancer antibodies, 16.88 and C-OU1 (B9165) ' Human antibodies and hybridomas, vol. 2, no. 4, pp. 215-21 .
Scopus-Elsevier
Europe PubMed Central

We have compared by SDS-PAGE Western blotting the molecules detected by two human monoclonal antibodies, C-OU1 and 16.88. The antibodies have previously been shown to detect a cytoplasmatic antigen with an Mr of 43 kD present in colon adenocarcinoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1cac9bc927cd1b70602c65cfc5e86c
https://doi.org/10.3233/hab-1991-2406

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Low surface expression of B7-1 (CD80) is an immunoescape mechanism of colon carcinoma

Autor: Mario P. Colombo, Iñigo Tirapu, Mikel Zaratiegui, Jesús Prieto, Carmen Berasain, Ignacio Melero, Pedro Berraondo, Puri Fortes, Oihana Murillo, Alvaro Gonzalez, Ainhoa Arina, Eduardo Huarte, Lieping Chen, Cristiana Guiducci

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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Artificially enforced expression of CD80 (B7-1) and CD86 (B7-2) on tumor cells renders them more immunogenic by triggering the CD28 receptor on T cells. The enigma is that such B7s interact with much higher affinity with CTLA-4 (CD152), an inhibitory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612a10add79d6ee2858a53fa6926a004
https://hdl.handle.net/10171/21800

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CD4+/CD25+ regulatory cells inhibit activation of tumor-primed CD4+ T cells with IFN-gamma-dependent antiangiogenic activity, as well as long-lasting tumor immunity elicited by peptide vaccination

Autor: Casares, N. (Noelia), Arribillaga, L. (Laura), Sarobe, P. (Pablo), Dotor, J. (Javier), Lopez-Diaz-de-Cerio, A. (Ascensión), Melero, I. (Ignacio), Lasarte, J.J. (Juan José)

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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CD25(+) regulatory T (T reg) cells suppress the activation/proliferation of other CD4(+) or CD8(+) T cells in vitro. Also, down-regulation of CD25(+) T reg cells enhance antitumor immune responses. In this study, we show that depletion of CD25(+) T r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a363e2eb34cea6f5233f01fbbc965607
https://hdl.handle.net/10171/20411

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Akademický článek

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Radiolabeled fragments of monoclonal antibodies against carcinoembryonic antigen for localization of human colon carcinoma grafted into nude mice

Autor: F Buchegger, B R Scazziga, C. Haskell, M Schreyer, J. P. Mach, S. Carrel, S Randin

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, vol. 158, no. 2, pp. 413-427

Four monoclonal antibodies against carcinoembryonic antigen (CEA) have been selected from 32 hybrids that produce antibodies against this antigen, by the criteria of high affinity for CEA and low cross-reactivity with granulocyte glycoprotein(s). The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849065293221a91462110604bcaa2580
http://europepmc.org/articles/PMC2187333

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Detection of colorectal carcinoma by emission-computerized tomography after injection of 123I-labeled Fab or F(ab')2 fragments from monoclonal anti-carcinoembryonic antigen antibodies

Autor: B. Delaloye, Angelika Bischof-Delaloye, V von Fliedner, J. Pettavel, F. Buchegger, J. P. Grob, J P Mach, J. C. Volant

Publikováno v: Journal of Clinical Investigation, vol. 77, no. 1, pp. 301-311

This clinical study was based on experimental results obtained in nude mice grafted with human colon carcinoma, showing that injected 131I-labeled F(ab')2 and Fab fragments from high affinity anti-carcinoembryonic antigen (CEA) monoclonal antibodies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fafc963b32e92e092a790b63c6d7efa8
https://serval.unil.ch/resource/serval:BIB_9EB07FFCFC18.P001/REF.pdf

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An anti-ICAM-2 (CD102) monoclonal antibody induces immune-mediated regressions of transplanted ICAM-2-negative colon carcinomas

Autor: Melero, I., Gabari, I., Corbí, A. L., Relloso, M., Mazzolini, G., Schmitz, V., Rodriguez-Calvillo, M., Tirapu, I., Camafeita, E., Albar, J. P., Jesús Prieto

Publikováno v: Scopus-Elsevier
Europe PubMed Central
ResearcherID
Dadun. Depósito Académico Digital de la Universidad de Navarra
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Web of Science

Monoclonal antibodies (mAbs) can mediate antitumor effects by indirect mechanisms involving antiangiogenesis and up-regulation of the cellular immune response rather than by direct tumor cell destruction. From mAbs raised by immunization of rats with

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http://www.scopus.com/inward/record.url?eid=2-s2.0-0036606328&partnerID=MN8TOARS

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Identification of an antigenic epitope for helper T lymphocytes from carcinoembryonic antigen

Autor: Kobayashi, H., Omiya, R., Ruiz, M., Huarte, E., Sarobe, P., Juan J Lasarte, Herraiz, M., Sangro, B., Prieto, J., Borras-Cuesta, F., Celis, E.

Publikováno v: Publons
CIÊNCIAVITAE
Europe PubMed Central
Dadun. Depósito Académico Digital de la Universidad de Navarra
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Scopus-Elsevier
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PURPOSE: The product of the carcinoembryonic antigen (CEA) gene is an attractive candidate for T-cell-based immunotherapy because it is frequently expressed in epithelial solid carcinomas. Although many CEA peptide epitopes capable of stimulating CTL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0bcadb8a4fda17025a9ac5bf03c94f29
https://publons.com/publon/3711744/

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