Opportunities on the horizon for the management of early colon cancer

Publikováno v: Critical Reviews in Oncology/Hematology. 183

There is a clear unmet need to improve early colon cancer management. This review encompasses the current systemic treatment landscape and summarises novel and pivotal trials. The Immunoscore and circulating tumour DNA (ctDNA) are studied to evaluate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___01423::6aa99fb39977a098d76d32993358e2d6
https://research.rug.nl/en/publications/6f3dac10-3b5b-4266-a414-580c6945d403

Impact of microsatellite status in early-onset colonic cancer

Autor: Zaborowski, Alexandra M., Adamina, Ahmed Abdile. Michel, Aigner, Felix, D'Allens, Laura, Allmer, Caterina, Álvarez, Andrea, Anula, Rocio, Andric, Mihailo, Bach, Sam Atallah Simon, Bala, Miklosh, Barussaud, Marie, Bausys, Augustinas, Beggs, Andrew, Bellolio, Felipe, Bennett, Melissa-Rose, Berdinskikh, Anton, Bevan, Vicki, Biondo, Sebastiano, Bislenghi, Gabriele, Bludau, Marc, Brouwer, Nelleke, Brown, Carl, Bruns, Christiane, Buchanan, Daniel D., Buchwald, Pamela, Burger, Jacobus W. A., Burlov, Nikita, Campanelli, Michela, Capdepont, Maylis, Carvello, Michele, Chew, Hwee-Hoon, Christoforidis, Dimitri, Clark, David, Climent, Marta, Collinson, Rowan, Cologne, Kyle G., Contreras, Tomas, Croner, Roland, Daniels, Ian R., Dapri, Giovanni, Davies, Justin, Delrio, Paolo, Denost, Quentin, Deutsch, Michael, Dias, Andre, D'Hoore, Andre, Drozdov, Evgeniy, Duek, Daniel, Dunlop, Malcolm, Dziki, Adam, Edmundson, Aleksandra, Efetov, Sergey, el-Hussuna, Alaa, Elliot, Brodie, Emile, Sameh, Espin, Eloy, Evans, Martyn, Faes, Seraina, Faiz, Omar, Figueiredo, Nuno, Fleming, Fergal, Foppa, Caterina, Fowler, George, Frasson, Matteo, Forgan, Tim, Frizelle, Frank, Gadaev, Shamil, Gellona, Jose, Glyn, Tamara, Goran, Barisic, Greenwood, Emma, Guren, Marianne G., Guillon, Stephanie, Gutlic, Ida, Hahnloser, Dieter, Hampel, Heather, Hanly, Ann, Hasegawa, Hirotoshi, Iversen, Lene Hjerrild, Hill, Andrew, Hill, James, Hoch, Jiri, Hompes, Roel, Hurtado, Luis, Iaquinandi, Fabiano, Imbrasaite, Ugne, Islam, Rumana, Jafari, Mehrenah D., Salido, Andrea Jimenez, Jimenez-Toscano, Marta, Kanemitsu, Yukihide, Karachun, Aleksei, Karimuddin, Ahmer A., Keller, Deborah S., Kelly, Justin, Kennelly, Rory, Khrykov, Gleb, Kocian, Peter, Koh, Cherry, Kok, Neils, Knight, Katrina A., Knol, Joep, Kontovounisios, Christos, Korner, Hartwig, Krivokapic, Zoran, Kronberger, Irmgard, Kroon, Hidde Maarten, Kryzauskas, Marius, Kural, Said, Kusters, Miranda, Lakkis, Zaher, Lankov, Timur, Larson, David, Lázár, György, Lee, Kai-Yin, Lee, Suk Hwan, Lefèvre, Jeremie H., Lepisto, Anna, Lieu, Christopher, Loi, Lynette, Lynch, Craig, Maillou-Martinaud, Helene, Maroli, Annalisa, Martin, Sean, Martling, Anna, Matzel, Klaus E., Mayol, Julio, McDermott, Frank, Meurette, Guillaume, Millan, Monica, Mitteregger, Martin, Moiseenko, Andrei, Monson, John Rt., Morarasu, Stefan, Moritani, Konosuke, Möslein, Gabriela, Munini, Martino, Nahas, Caio, Nahas, Sergio, Negoi, Ionut, Novikova, Anastasia, Ocares, Misael, Okabayashi, Koji, Olkina, Alexandra, Oñate-Ocaña, Luis, Otero, Jaime, Ozen, Cihan, Pace, Ugo, Julião, Guilherme Pagin S. o, Panaiotti, Lidiia, Panis, Yves, Papamichael, Demetris, Patel, Swati, Uriburu, Juan Carlos Patrón, Peng, Sze-Lin, Pera, Miguel, Perez, Rodrigo O., Petrov, Alexei, Pfeffer, Frank, Phang, Terry P., Poskus, Tomas, Pringle, Heather, Proud, David, Raguz, Ivana, Rama, Nuno, Rasheed, Shahnawaz, Raval, Manoj J., Rega, Daniela, Reissfelder, Christoph, Meneses, Juan Carlos Reyes, Ris, Frederic, Riss, Stefan, Rodriguez-Zentner, Homero, Roxburgh, Campbell S., Saklani, Avanish, Sammour, Tarik, Saraste, Deborah, Schneider, Martin, Seishima, Ryo, Sekulic, Aleksandar, Seppala, Toni, Sheahan, Kieran, Shlomina, Alexandra, Sigismondo, Guiseppe, Singnomklao, Tongplaew, Siragusa, Leandro, Smart, Neil, Solis-Peña, Alejandro, Spinelli, Antonino, Staiger, Roxane D., Stamos, Michael J., Steele, Scott, Tan, Ker-Kan, Tanis, Pieter J., Tekkis, Paris, Teklay, Biniam, Tengku, Sabrina, Tsarkov, Petr, Turina, Matthias, Ulrich, Alexis, Vailati, Bruna B., van Harten, Meike, Verhoef, Cornelis, Warrier, Satish, Wexner, Steven, de Wilt, Hans, Weinberg, Benjamin A., Wells, Cameron, Wolthuis, Albert, Xynos, Evangelos, You, Nancy, Zakharenko, Alexander, Zeballos, Justino, Zhou, Jonathan, Winter, Des C.

Publikováno v: REACCT Collaborative, El-Hussuna, A & Özen, C 2022, ' Impact of microsatellite status in early-onset colonic cancer ', British Journal of Surgery, vol. 109, no. 7, pp. 632-636 . https://doi.org/10.1093/bjs/znac108
British journal of surgery, 109(7), 632-636. John Wiley and Sons Ltd
Zaborowski, A M, Adamina, A A M, Aigner, F, D'Allens, L, Allmer, C, Álvarez, A, Anula, R, Andric, M, Bach, S A S, Bala, M, Barussaud, M, Bausys, A, Beggs, A, Bellolio, F, Bennett, M-R, Berdinskikh, A, Bevan, V, Biondo, S, Bislenghi, G, Bludau, M, Brouwer, N, Brown, C, Bruns, C, Buchanan, D D, Buchwald, P, Burger, J W A, Burlov, N, Campanelli, M, Capdepont, M, Carvello, M, Chew, H-H, Christoforidis, D, Clark, D, Climent, M, Collinson, R, Cologne, K G, Contreras, T, Croner, R, Daniels, I R, Dapri, G, Davies, J, Delrio, P, Denost, Q, Deutsch, M, Dias, A, D'Hoore, A, Drozdov, E, Duek, D, Dunlop, M, Dziki, A, Edmundson, A, Efetov, S, el-Hussuna, A, Elliot, B, Emile, S, Espin, E, Evans, M, Faes, S, Faiz, O, Figueiredo, N, Fleming, F, Foppa, C, Fowler, G, Frasson, M, Forgan, T, Frizelle, F, Gadaev, S, Gellona, J, Glyn, T, Goran, B, Greenwood, E, Guren, M G, Guillon, S, Gutlic, I, Hahnloser, D, Hampel, H, Hanly, A, Hasegawa, H, Iversen, L H, Hill, A, Hill, J, Hoch, J, Hompes, R, Hurtado, L, Iaquinandi, F, Imbrasaite, U, Islam, R, Jafari, M D, Salido, A J, Jimenez-Toscano, M, Kanemitsu, Y, Karachun, A, Karimuddin, A A, Keller, D S, Kelly, J, Kennelly, R, Khrykov, G, Kocian, P, Koh, C, Kok, N, Knight, K A, Knol, J, Kontovounisios, C, Korner, H, Krivokapic, Z, Kronberger, I, Kroon, H M, Kryzauskas, M, Kural, S, Kusters, M, Lakkis, Z, Lankov, T, Larson, D, Lázár, G, Lee, K-Y, Lee, S H, Lefèvre, J H, Lepisto, A, Lieu, C, Loi, L, Lynch, C, Maillou-Martinaud, H, Maroli, A, Martin, S, Martling, A, Matzel, K E, Mayol, J, McDermott, F, Meurette, G, Millan, M, Mitteregger, M, Moiseenko, A, Monson, J R, Morarasu, S, Moritani, K, Möslein, G, Munini, M, Nahas, C, Nahas, S, Negoi, I, Novikova, A, Ocares, M, Okabayashi, K, Olkina, A, Oñate-Ocaña, L, Otero, J, Ozen, C, Pace, U, Julião, G P S O, Panaiotti, L, Panis, Y, Papamichael, D, Patel, S, Uriburu, J C P, Peng, S-L, Pera, M, Perez, R O, Petrov, A, Pfeffer, F, Phang, T P, Poskus, T, Pringle, H, Proud, D, Raguz, I, Rama, N, Rasheed, S, Raval, M J, Rega, D, Reissfelder, C, Meneses, J C R, Ris, F, Riss, S, Rodriguez-Zentner, H, Roxburgh, C S, Saklani, A, Sammour, T, Saraste, D, Schneider, M, Seishima, R, Sekulic, A, Seppala, T, Sheahan, K, Shlomina, A, Sigismondo, G, Singnomklao, T, Siragusa, L, Smart, N, Solis-Peña, A, Spinelli, A, Staiger, R D, Stamos, M J, Steele, S, Tan, K-K, Tanis, P J, Tekkis, P, Teklay, B, Tengku, S, Tsarkov, P, Turina, M, Ulrich, A, Vailati, B B, van Harten, M, Verhoef, C, Warrier, S, Wexner, S, de Wilt, H, Weinberg, B A, Wells, C, Wolthuis, A, Xynos, E, You, N, Zakharenko, A, Zeballos, J, Zhou, J & Winter, D C 2022, ' Impact of microsatellite status in early-onset colonic cancer ', British Journal of Surgery, vol. 109, no. 7, pp. 632-636 . https://doi.org/10.1093/bjs/znac108
British Journal of Surgery, 109(7), 632-636. John Wiley and Sons Ltd
REACCT Collaborative 2022, ' Impact of microsatellite status in early-onset colonic cancer ', British Journal of Surgery, vol. 109, no. 7, pp. 632-636 . https://doi.org/10.1093/bjs/znac108

Background The molecular profile of early-onset colonic cancer is undefined. This study evaluated clinicopathological features and oncological outcomes of young patients with colonic cancer according to microsatellite status. Methods Anonymized data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba3b64d1f8359f23c33851c100502bd
https://doi.org/10.1093/bjs/znac108

CHEK2 1100DELC germline mutation: a frequency study in hereditary breast and colon cancer Brazilian families Mutação germinativa 1100delC no gene CHEK2: estudo da frequência em famílias brasileiras com câncer de mama e cólon hereditários

Autor: Jamile Abud, João Carlos Prolla

Publikováno v: Arquivos de Gastroenterologia, Vol 49, Iss 4, Pp 273-278 (2012)

CONTEXT: CHEK2 encodes a cell cycle checkpoint kinase that plays an important role in the DNA damage repair pathway, activated mainly by ATM (Ataxia Telangiectasia Mutated) in response to double-stranded DNA breaks. A germline mutation in CHEK2, 1100

Externí odkaz: https://doaj.org/article/13e43769cc3249cebe41ec49d3aa4383

Survival impact of adjuvant chemotherapy in patients with stage IIA colon cancer: Analysis of the National Cancer Database

Autor: David W. Larson, Mohamed A. Abd El Aziz, Pietro Achilli, Courtney N. Day, Anne-Lise D. D'Angelo, Jacopo Crippa, William S. Harmsen, Fabian Grass, Kellie L. Mathis

Publikováno v: International journal of cancer, vol. 148, no. 1, pp. 161-169

Utility of adjuvant chemotherapy for stage II cancer remains a matter of debate. Clinical guidelines suggest adjuvant chemotherapy for stage II tumors with high-risk features, in particular T4 tumors. However, limited consensus exists regarding the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8326bc25e2a735f527dd371086aa9d
https://serval.unil.ch/resource/serval:BIB_0BFC462249D2.P001/REF.pdf

Upregulated Na+/H+-exchange protects human colon cancer tissue against intracellular acidification

Autor: Henrik Kold-Petersen, Ninna C. S. Voss, Casper Homilius, Ebbe Boedtkjer, Mikkel B. Henningsen

Publikováno v: Voss, N C S, Kold-Petersen, H H, Henningsen, M B, Homilius, C & Boedtkjer, E 2019, ' Upregulated Na + /H +-exchange protects human colon cancer tissue against intracellular acidification ', BioMed Research International, vol. 2019, 3702783 . https://doi.org/10.1155/2019/3702783
BioMed Research International
BioMed Research International, Vol 2019 (2019)

Increased metabolism accelerates local acid production in cancer tissue. The mechanisms eliminating acidic waste products from human colon cancer tissue represent promising therapeutic targets for pharmacological manipulation in order to improve prog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100bf714c00d6aa3a98379d7784224cf
https://pure.au.dk/portal/da/publications/upregulated-nahexchange-protects-human-colon-cancer-tissue-against-intracellular-acidification(08df03a6-f0bc-4f85-9e91-5d4daf27a06f).html