Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD.

Autor: Seddighi S; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.; Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Qi YA; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA., Brown AL; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Wilkins OG; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK.; The Francis Crick Institute, London, UK., Bereda C; Medical Scientist Training Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA., Belair C; Laboratory of Genetics and Genomics, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA., Zhang Y; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Prudencio M; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Keuss MJ; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Khandeshi A; Laboratory of Genetics and Genomics, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA., Pickles S; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Hill SE; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Hawrot J; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Ramos DM; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA., Yuan H; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Roberts J; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA., Kelmer Sacramento E; Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany., Shah SI; Data Tecnica International, Washington, DC, USA., Nalls MA; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International, Washington, DC, USA., Colon-Mercado J; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Reyes JF; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Ryan VH; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Nelson MP; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA., Cook C; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Li Z; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International, Washington, DC, USA., Screven L; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA., Kwan JY; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Shantaraman A; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA., Ping L; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA., Koike Y; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Oskarsson B; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Staff N; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Duong DM; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA., Ahmed A; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Secrier M; Department of Genetics, Evolution and Environment, UCL Genetics Institute, UCL, London, UK., Ule J; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Jacobson S; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA., Rohrer J; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Malaspina A; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Glass JD; Department of Neurology, Center for Neurodegenerative Diseases, Emory University, Atlanta, GA, USA., Ori A; Leibniz Institute on Aging - Fritz Lipmann Institute (FLI), Jena, Germany., Seyfried NT; Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA., Maragkakis M; Laboratory of Genetics and Genomics, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA., Petrucelli L; Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.; Neuroscience Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Jacksonville, FL, USA., Fratta P; UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, UCL, London, UK., Ward ME; National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 23. Date of Electronic Publication: 2023 Jan 23.