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pro vyhledávání: '"Colm M. Ryan"'
Publikováno v:
Biochemical and Biophysical Research Communications
The lysine acetyltransferase CREB binding protein (CBP) is required for chromatin modification and transcription at many gene promoters. In fixed cells, a large proportion of CBP colocalises to PML or nuclear bodies. Using live cell imaging, we show
Publikováno v:
Cell Cycle. 5:2146-2152
Nuclear transport proteins such as CSE1, NUP93 and Importin-alpha have recently been shown to be chromatin-associated proteins in yeast, which have unexpected functions in gene regulation. Here we report interactions between the mammalian histone ace
Autor:
Colm M. Ryan, Sachiko Matsuda, Hilary M. Collins, Eric Kalkhoven, Karin B. Kindle, David M. Heery, Philip J. F. Troke
Publikováno v:
Journal of Biological Chemistry. 281:17124-17133
MOZ-TIF2 and MOZ-CBP are leukemogenic fusion proteins associated with therapy-induced acute myeloid leukemia. These proteins are thought to subvert normal gene expression in differentiating hematopoietic progenitor cells. We have previously shown tha
Autor:
Janet C. Harries, Philip J. F. Troke, Karin B. Kindle, David M. Heery, Maria Viskaduraki, Sachiko Matsuda, Colm M. Ryan
Publikováno v:
Journal of Biological Chemistry. 279:14055-14064
CREB-binding protein (CBP) and p300 contain modular domains that mediate protein-protein interactions with a wide variety of nuclear factors. A C-terminal domain of CBP (referred to as the SID) is responsible for interaction with the alpha-helical AD