Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Colm J, O'Brien"'
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153354 (2016)
PURPOSE:Fibrosis and a hypoxic environment are associated with the trabecular meshwork (TM) region in the blinding disease glaucoma. Hypoxia has been shown to alter DNA methylation, an epigenetic mechanism involved in regulating gene expression such
Externí odkaz:
https://doaj.org/article/e999b8c005c44e0083f97a7fc2cb0900
Autor:
Mustapha Irnaten, Colm J. O’Brien
Publikováno v:
International Journal of Molecular Sciences. 24:1287
Glaucoma is one of the most common causes of treatable visual impairment in the developed world, affecting approximately 64 million people worldwide, some of whom will be bilaterally blind from irreversible optic nerve damage. The optic nerve head is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4094f3e1d987236a6897b426dde8f45c
https://doi.org/10.3390/ijms24021287
https://doi.org/10.3390/ijms24021287
Autor:
Rory Murphy, Mustapha Irnaten, Alan Hopkins, Jeffrey O'Callaghan, W. Daniel Stamer, Abbot F. Clark, Deborah Wallace, Colm J. O'Brien
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Extracellular matrix stiffening is characteristic of both aging and glaucoma, and acts as a promoter and perpetuator of pathological fibrotic remodeling. Here, we investigate the role of a mechanosensitive transcriptional coactivator, Yes-ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4714cfbf81c762758ba63c25f546154
https://doi.org/10.1167/iovs.63.1.16
https://doi.org/10.1167/iovs.63.1.16
Autor:
Colm J. O'Brien
Publikováno v:
Journal of Urban Design. 2:163-178
This paper discusses the urban waterfront in Newcastle‐upon‐Tyne as a case study in the handling of the ‘past’ in urban regeneration. It explores the connections between the outcomes of the conservation process and the ‘past’ that suppose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a65a26d6a4f8d9443d66d6bfae4580e3
https://doi.org/10.1080/13574809708724402
https://doi.org/10.1080/13574809708724402
Publikováno v:
Clinicalexperimental ophthalmology. 39(3)
This paper seeks to investigate differences between the neonatal and adult retinal ganglion cell populations to apoptotic death stimuli. DESIGN AND SAMPLES: In vitro and ex vivo paradigms involving P6 and P60 Sprague-Dawley rat retinal explants and r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3bd4a6109d7f846f349bfee94c5a539
https://pubmed.ncbi.nlm.nih.gov/21489112
https://pubmed.ncbi.nlm.nih.gov/21489112
Autor:
Stephen M J, Farrell, Gillian, Groeger, Lavinia, Bhatt, Sorcha, Finnegan, Colm J, O'Brien, Thomas G, Cotter
Publikováno v:
The European journal of neuroscience. 33(4)
In many retinal diseases, it is the death of photoreceptors that leads to blindness. In previous in vitro and in vivo studies, basic fibroblast growth factor (bFGF) has been shown to increase retinal cell survival. More recently, reactive oxygen spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d73d85255f051b6ad136ded8681aa079
https://pubmed.ncbi.nlm.nih.gov/21219477
https://pubmed.ncbi.nlm.nih.gov/21219477
Publikováno v:
Molecular Vision
Purpose Marked extracellular matrix (ECM) remodeling occurs in the human optic nerve head in primary open angle glaucoma (POAG). The glial fibrillary acid protein (GFAP) negative lamina cribrosa cell may play an important role in this remodeling proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e42def8f09512dcbe2c7201fa3f7fc55
https://pubmed.ncbi.nlm.nih.gov/19145252
https://pubmed.ncbi.nlm.nih.gov/19145252
Publikováno v:
Molecular vision. 12
Cyclooxygenases (COX-1 and COX-2) and prostaglandins regulate angiogenesis in several settings, including cancer and ischemia. In the eye, both selective inhibitors of COX-2 and nonselective COX inhibitors are reported to suppress ischemia-related re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::465537ff74670dbeb24ecf1a006f9cd1
https://pubmed.ncbi.nlm.nih.gov/16688111
https://pubmed.ncbi.nlm.nih.gov/16688111
Autor:
Ruaidhrí P, Kirwan, Cecilia H, Fenerty, John, Crean, Robert J, Wordinger, Abbot F, Clark, Colm J, O'Brien
Publikováno v:
Molecular vision. 11
The mechanical effect of raised intraocular pressure is a recognised stimulus for optic neuropathy in primary open angle glaucoma (POAG). Characteristic extracellular matrix (ECM) remodelling accompanies axonal damage in the lamina cribrosa (LC) of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d5ecc29f93e4a067d37a4d8ed50e798
https://pubmed.ncbi.nlm.nih.gov/16205625
https://pubmed.ncbi.nlm.nih.gov/16205625
Publikováno v:
Glia; Dec2005, Vol. 52 Issue 4, p309-324, 0p