N-methyl-D-aspartate receptor availability in first-episode psychosis: a PET-MR brain imaging study

Autor: Katherine Beck, Atheeshaan Arumuham, Mattia Veronese, Barbara Santangelo, Colm J. McGinnity, Joel Dunn, Robert A. McCutcheon, Stephen J. Kaar, Nisha Singh, Toby Pillinger, Faith Borgan, James Stone, Sameer Jauhar, Teresa Sementa, Federico Turkheimer, Alexander Hammers, Oliver D. Howes

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)

Abstract N-methyl-D-aspartate receptor (NMDAR) hypofunction is hypothesised to underlie psychosis but this has not been tested early in illness. To address this, we studied 40 volunteers (21 patients with first-episode psychosis and 19 matched health

Externí odkaz: https://doaj.org/article/01e5daca97374a1c9b30a252f899148c

A Retrospective Case Series Analysis of the Relationship Between Phenylalanine: Tyrosine Ratio and Cerebral Glucose Metabolism in Classical Phenylketonuria and Hyperphenylalaninemia

Autor: Colm J. McGinnity, Daniela A. Riaño Barros, Eric Guedj, Nadine Girard, Christopher Symeon, Helen Walker, Sally F. Barrington, Mary Summers, Mervi Pitkanen, Yusof Rahman

Publikováno v: Frontiers in Neuroscience, Vol 15 (2021)

We retrospectively examined the relationship between blood biomarkers, in particular the historical mean phenylalanine to tyrosine (Phe:Tyr) ratio, and cerebral glucose metabolism. We hypothesized that the historical mean Phe:Tyr ratio would be more

Externí odkaz: https://doaj.org/article/608ffd9e583b44be95a6b06cef7a8413

Simplifying [18F]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential?

Autor: Colm J. McGinnity, Daniela A. Riaño Barros, William Trigg, David J. Brooks, Rainer Hinz, John S. Duncan, Matthias J. Koepp, Alexander Hammers

Publikováno v: EJNMMI Research, Vol 8, Iss 1, Pp 1-8 (2018)

Abstract Introduction The NMDA receptor radiotracer [18F]GE-179 has been used with 90-min scans and arterial plasma input functions. We explored whether (1) arterial blood sampling is avoidable and (2) shorter scans are feasible. Methods For 20 exist

Externí odkaz: https://doaj.org/article/b3680a97467645028a5c8946536bcd39

The association between N-methyl-d-aspartate receptor availability and glutamate levels:A multi-modal PET-MR brain imaging study in first-episode psychosis and healthy controls

Autor: Katherine Beck, Atheeshaan Arumuham, Stefan Brugger, Robert A McCutcheon, Mattia Veronese, Barbara Santangelo, Colm J McGinnity, Joel Dunn, Stephen Kaar, Nisha Singh, Toby Pillinger, Faith Borgan, Teresa Sementa, Radhouene Neji, Sameer Jauhar, Franklin Aigbirhio, Istvan Boros, Federico Turkheimer, Alexander Hammers, David Lythgoe, James Stone, Oliver D Howes

Publikováno v: Beck, K, Arumuham, A, Brugger, S, McCutcheon, R A, Veronese, M, Santangelo, B, McGinnity, C J, Dunn, J, Kaar, S, Singh, N, Pillinger, T, Borgan, F, Sementa, T, Neji, R, Jauhar, S, Aigbirhio, F, Boros, I, Turkheimer, F, Hammers, A, Lythgoe, D, Stone, J & Howes, O D 2022, ' The association between N-methyl-d-aspartate receptor availability and glutamate levels : A multi-modal PET-MR brain imaging study in first-episode psychosis and healthy controls ', Journal of psychopharmacology (Oxford, England), vol. 36, no. 9, pp. 1051-1060 . https://doi.org/10.1177/02698811221099643

Background: Evidence from post-mortem studies and in vivo imaging studies suggests there may be reduced N-methyl-d-aspartate receptor (NMDAR) levels in the hippocampus in patients with schizophrenia. Other studies have reported increased glutamate in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6447a0ee7a2d68ead15c25c3f70e79e7
https://kclpure.kcl.ac.uk/ws/files/184987017/The_association_between_BECK_Publishedonline19September2022_GREEN_AAM.pdf

Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

Autor: Justine Y. Hansen, Golia Shafiei, Ross D. Markello, Kelly Smart, Sylvia M. L. Cox, Martin Nørgaard, Vincent Beliveau, Yanjun Wu, Jean-Dominique Gallezot, Étienne Aumont, Stijn Servaes, Stephanie G. Scala, Jonathan M. DuBois, Gabriel Wainstein, Gleb Bezgin, Thomas Funck, Taylor W. Schmitz, R. Nathan Spreng, Marian Galovic, Matthias J. Koepp, John S. Duncan, Jonathan P. Coles, Tim D. Fryer, Franklin I. Aigbirhio, Colm J. McGinnity, Alexander Hammers, Jean-Paul Soucy, Sylvain Baillet, Synthia Guimond, Jarmo Hietala, Marc-André Bédard, Marco Leyton, Eliane Kobayashi, Pedro Rosa-Neto, Melanie Ganz, Gitte M. Knudsen, Nicola Palomero-Gallagher, James M. Shine, Richard E. Carson, Lauri Tuominen, Alain Dagher, Bratislav Misic

Publikováno v: Nature neuroscience 25(11), 1569-1581 (2022). doi:10.1038/s41593-022-01186-3
Hansen, J Y, Shafiei, G, Markello, R D, Smart, K, Cox, S M L, Nørgaard, M, Beliveau, V, Wu, Y, Gallezot, J-D, Aumont, É, Servaes, S, Scala, S G, DuBois, J M, Wainstein, G, Bezgin, G, Funck, T, Schmitz, T W, Spreng, R N, Galovic, M, Koepp, M J, Duncan, J S, Coles, J P, Fryer, T D, Aigbirhio, F I, McGinnity, C J, Hammers, A, Soucy, J-P, Baillet, S, Guimond, S, Hietala, J, Bedard, M-A, Leyton, M, Kobayashi, E, Rosa-Neto, P, Ganz, M, Knudsen, G M, Palomero-Gallagher, N, Shine, J M, Carson, R E, Tuominen, L, Dagher, A & Misic, B 2022, ' Mapping neurotransmitter systems to the structural and functional organization of the human neocortex ', Nature Neuroscience, vol. 25, pp. 1569–1581 . https://doi.org/10.1038/s41593-022-01186-3

Funder: Helmholts International BigBrain Analytics & Learning Laboratory
Neurotransmitter receptors support the propagation of signals in the human brain. How receptor systems are situated within macro-scale neuroanatomy and how they shape emerg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f38b473f0a2f07ec39cd40777f19ff9
https://hdl.handle.net/2128/32625