Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Colm A. Ryan"'
Autor:
Diego Ristè, Marcus P. da Silva, Colm A. Ryan, Andrew W. Cross, Antonio D. Córcoles, John A. Smolin, Jay M. Gambetta, Jerry M. Chow, Blake R. Johnson
Publikováno v:
npj Quantum Information, Vol 3, Iss 1, Pp 1-5 (2017)
Large advantage in small quantum computers Quantum computing promises to revolutionize all fields of science by solving problems that are too complex for conventional computers. However, the realization of a full-fledged, universal quantum computer i
Externí odkaz:
https://doaj.org/article/b5566ab8f0a84a03ad96e12cf550175d
Publikováno v:
Physical Review X, Vol 6, Iss 2, p 029902 (2016)
Externí odkaz:
https://doaj.org/article/fa491e7852034fc681ad006f4dc554a3
Publikováno v:
Physical Review X, Vol 4, Iss 1, p 011050 (2014)
We describe how randomized benchmarking can be used to reconstruct the unital part of any trace-preserving quantum map, which in turn is sufficient for the full characterization of any unitary evolution or, more generally, any unital trace-preserving
Externí odkaz:
https://doaj.org/article/3ff3a915ee48432e8fabc02023914bc6
Autor:
Barbara De Kegel, Colm J Ryan
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 12, Pp n/a-n/a (2023)
Abstract Genomic instability is a hallmark of cancer, resulting in tumor genomes having large numbers of genetic aberrations, including homozygous deletions of protein coding genes. That tumor cells remain viable in the presence of such gene loss sug
Externí odkaz:
https://doaj.org/article/7ff233f2496043a2820614b2f23f86f0
Publikováno v:
Cell Reports: Methods, Vol 2, Iss 9, Pp 100288- (2022)
Summary: Large-scale studies of human proteomes have revealed only a moderate correlation between mRNA and protein abundances. It is unclear to what extent this moderate correlation reflects post-transcriptional regulation and to what extent it refle
Externí odkaz:
https://doaj.org/article/9423032250c4410d9db70ddc837c7206
Publikováno v:
Trends in Cancer. 9:397-409
Autor:
Andrey A Parkhitko, Arashdeep Singh, Sharon Hsieh, Yanhui Hu, Richard Binari, Christopher J Lord, Sridhar Hannenhalli, Colm J Ryan, Norbert Perrimon
Publikováno v:
PLoS Genetics, Vol 17, Iss 2, p e1009354 (2021)
The RB1 tumor suppressor is recurrently mutated in a variety of cancers including retinoblastomas, small cell lung cancers, triple-negative breast cancers, prostate cancers, and osteosarcomas. Finding new synthetic lethal (SL) interactions with RB1 c
Externí odkaz:
https://doaj.org/article/5d7da79486b143a8a4352f9eed0f8e17
Autor:
Vít Nováček, Gavin McGauran, David Matallanas, Adrián Vallejo Blanco, Piero Conca, Emir Muñoz, Luca Costabello, Kamalesh Kanakaraj, Zeeshan Nawaz, Brian Walsh, Sameh K Mohamed, Pierre-Yves Vandenbussche, Colm J Ryan, Walter Kolch, Dirk Fey
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1007578 (2020)
Phosphorylation of specific substrates by protein kinases is a key control mechanism for vital cell-fate decisions and other cellular processes. However, discovering specific kinase-substrate relationships is time-consuming and often rather serendipi
Externí odkaz:
https://doaj.org/article/25d2415552804e8fa21e45dbf2bf6550
Publikováno v:
eLife, Vol 9 (2020)
Genetic interactions, including synthetic lethal effects, can now be systematically identified in cancer cell lines using high-throughput genetic perturbation screens. Despite this advance, few genetic interactions have been reproduced across multipl
Externí odkaz:
https://doaj.org/article/8e586e747ad4476bb5d11047dd6bd123
Autor:
Barbara De Kegel, Colm J Ryan
Publikováno v:
PLoS Genetics, Vol 15, Iss 10, p e1008466 (2019)
What makes a gene essential for cellular survival? In model organisms, such as budding yeast, systematic gene deletion studies have revealed that paralog genes are less likely to be essential than singleton genes and that this can partially be attrib
Externí odkaz:
https://doaj.org/article/f88b9132e41940a19acd50e4fbb55514