Altered erythropoiesis via JAK2 and ASXL1 mutations in myeloproliferative neoplasms.

Autor: Collins TB; Division of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Laranjeira ABA; Division of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Kong T; Division of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Fulbright MC; Division of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Fisher DAC; Division of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO., Sturgeon CM; Division of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai School of Medicine, New York, NY; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY., Batista LFZ; Division of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO; Center for Genome Integrity, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO., Oh ST; Division of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO; Immunomonitoring Laboratory, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO. Electronic address: stoh@wustl.edu.

Publikováno v: Experimental hematology [Exp Hematol] 2024 Apr; Vol. 132, pp. 104178. Date of Electronic Publication: 2024 Feb 09.

Cytokine production in myelofibrosis exhibits differential responsiveness to JAK-STAT, MAP kinase, and NFκB signaling.

Autor: Fisher DAC; Division of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Miner CA; Immunomonitoring Laboratory, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA., Engle EK; Division of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Hu H; Division of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.; Program in Biostatistics, Washington University School of Medicine, St. Louis, MO, USA., Collins TB; Division of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Zhou A; Division of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Allen MJ; Division of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., Malkova ON; Immunomonitoring Laboratory, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA., Oh ST; Division of Hematology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. stoh@wustl.edu.; Immunomonitoring Laboratory, Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO, USA. stoh@wustl.edu.

Publikováno v: Leukemia [Leukemia] 2019 Aug; Vol. 33 (8), pp. 1978-1995. Date of Electronic Publication: 2019 Feb 04.

Elevated levels of damageassociated molecular patterns HMGB1 and S100A8/A9 coupled with toll-like receptor-triggered monocyte activation are associated with inflammation in patients with myelofibrosis.

Autor: De Luca, Geraldine, Goette, Nora P., Lev, Paola R., Baroni Pietto, Maria C., Marin Oyarzún, Cecilia P., Castro Rıós, Miguel A., Moiraghi, Beatriz, Sackmann, Federico, Kamiya, Laureano J., Verri, Veronica, Caula, Victoria, Fernandez, Vanina, Vicente, Angeles, Pose Cabarcos, Julio, Caruso, Vanesa, Camacho, Maria F., Larripa, Irene B., Khoury, Marina, Marta, Rosana F., Glembotsky, Ana C.

Publikováno v: Frontiers in Immunology; 2024, p1-17, 17p

Elevated levels of damage-associated molecular patterns HMGB1 and S100A8/A9 coupled with toll-like receptor-triggered monocyte activation are associated with inflammation in patients with myelofibrosis.

Autor: De Luca, Geraldine, Goette, Nora P., Lev, Paola R., Baroni Pietto, Maria C., Marin Oyarzún, Cecilia P., Castro Ríos, Miguel A., Moiraghi, Beatriz, Sackmann, Federico, Kamiya, Laureano J., Verri, Veronica, Caula, Victoria, Fernandez, Vanina, Vicente, Angeles, Pose Cabarcos, Julio, Caruso, Vanesa, Camacho, Maria F., Larripa, Irene B., Khoury, Marina, Marta, Rosana F., Glembotsky, Ana C.

Publikováno v: Frontiers in Immunology; 2024, p1-17, 17p

Type II mode of JAK2 inhibition and destabilization are potential therapeutic approaches against the ruxolitinib resistance driven myeloproliferative neoplasms.

Autor: Gorantla, Sivahari P., Prince, Gerin, Osius, Jasmin, Dinesh, Dhurvas Chandrasekaran, Boddu, Vijay, Duyster, Justus, von Bubnoff, Nikolas

Publikováno v: Frontiers in Oncology; 2024, p1-18, 18p