Recruitment of FBXO22 for targeted degradation of NSD2.

Autor: Nie DY; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Tabor JR; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Li J; University of Florida Health Cancer Center, Gainesville, FL, USA.; Department of Pharmacology, Physiology, and Cancer Biology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA., Kutera M; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., St-Germain J; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Hanley RP; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; C4 Therapeutics, Watertown, MA, USA., Wolf E; Department of Chemistry, York University, Toronto, Ontario, Canada., Paulakonis E; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA., Kenney TMG; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Duan S; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Shrestha S; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Owens DDG; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.; Amphista Therapeutics, Cambridge, UK., Maitland MER; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada., Pon A; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada., Szewczyk M; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada., Lamberto AJ; University of Florida Health Cancer Center, Gainesville, FL, USA., Menes M; University of Florida Health Cancer Center, Gainesville, FL, USA., Li F; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada., Penn LZ; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada.; Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario, Canada., Brown NG; Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Barsotti AM; Deerfield Discovery and Development, Deerfield Management, New York, NY, USA., Stamford AW; Deerfield Discovery and Development, Deerfield Management, New York, NY, USA., Collins JL; Office of the Vice Chancellor for Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Wilson DJ; Department of Chemistry, York University, Toronto, Ontario, Canada., Raught B; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada., Licht JD; University of Florida Health Cancer Center, Gainesville, FL, USA., James LI; Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ingerman@email.unc.edu.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. ingerman@email.unc.edu., Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, Ontario, Canada. cheryl.arrowsmith@uhn.ca.; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. cheryl.arrowsmith@uhn.ca.; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. cheryl.arrowsmith@uhn.ca.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2024 Dec; Vol. 20 (12), pp. 1597-1607. Date of Electronic Publication: 2024 Jul 04.

Ube3a unsilencer for the potential treatment of Angelman syndrome.

Autor: Vihma H; Department of Cell Biology and Physiology, Neuroscience Center, and Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Li K; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Welton-Arndt A; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Smith AL; Department of Cell Biology and Physiology, Neuroscience Center, and Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Bettadapur KR; Department of Cell Biology and Physiology, Neuroscience Center, and Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Gilmore RB; Department of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT, USA., Gao E; Department of Cell Biology and Physiology, Neuroscience Center, and Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Cotney JL; Department of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT, USA., Huang HC; Deerfield Discovery and Development, Deerfield Management, New York, NY, USA., Collins JL; Office of the Vice Chancellor for Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Chamberlain SJ; Department of Genetics and Genome Sciences, University of Connecticut School of Medicine, Farmington, CT, USA., Lee HM; Department of Cell Biology and Physiology, Neuroscience Center, and Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. dr.hmlee@gmail.com.; Department of Biochemistry and Molecular Biology, Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, USA. dr.hmlee@gmail.com., Aubé J; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. jaube@email.unc.edu.; Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. jaube@email.unc.edu., Philpot BD; Department of Cell Biology and Physiology, Neuroscience Center, and Carolina Institute for Developmental Disabilities, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. bphilpot@med.unc.edu.

Publikováno v: Nature communications [Nat Commun] 2024 Jul 08; Vol. 15 (1), pp. 5558. Date of Electronic Publication: 2024 Jul 08.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Microfluidic reactor designed for time-lapsed imaging of pretreatment and enzymatic hydrolysis of lignocellulosic biomass.

Autor: Chandrasekar M; Department of Chemical Engineering, Michigan Technological University, 1400 Townsend Drive, Houghton, 49931, MI, USA; DOE Great Lakes Bioenergy Research Center, Michigan Technological University, 1400 Townsend Drive, Houghton, 49931, MI, USA., Collins JL; Department of Chemical Engineering, Michigan Technological University, 1400 Townsend Drive, Houghton, 49931, MI, USA., Habibi S; Department of Chemical Engineering, Michigan Technological University, 1400 Townsend Drive, Houghton, 49931, MI, USA., Ong RG; Department of Chemical Engineering, Michigan Technological University, 1400 Townsend Drive, Houghton, 49931, MI, USA; DOE Great Lakes Bioenergy Research Center, Michigan Technological University, 1400 Townsend Drive, Houghton, 49931, MI, USA. Electronic address: rgong1@mtu.edu.

Publikováno v: Bioresource technology [Bioresour Technol] 2024 Feb; Vol. 393, pp. 129989. Date of Electronic Publication: 2023 Nov 04.