Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Collin Zimmer"'
Autor:
Francisco J. Medrano, Sergio de la Hoz-Rodríguez, Sergio Martí, Kemel Arafet, Tanja Schirmeister, Stefan J. Hammerschmidt, Christin Müller, Águeda González-Martínez, Elena Santillana, John Ziebuhr, Antonio Romero, Collin Zimmer, Annabelle Weldert, Robert Zimmermann, Alessio Lodola, Katarzyna Świderek, Vicent Moliner, Florenci V. González
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract The coronavirus disease 2019 (COVID-19) pandemic continues to represent a global public health issue. The viral main protease (Mpro) represents one of the most attractive targets for the development of antiviral drugs. Herein we report pepti
Externí odkaz:
https://doaj.org/article/3ea31cb9aaef4184b8998a4dd4345a66
Autor:
Collin Zimmer, Jan Brauer, Dorota Ferenc, Jessica Meyr, Patrick Müller, Hans-Joachim Räder, Bernd Engels, Till Opatz, Tanja Schirmeister
Publikováno v:
Molecules, Vol 29, Iss 11, p 2660 (2024)
The aim of this study was to investigate the transition from non-covalent reversible over covalent reversible to covalent irreversible inhibition of cysteine proteases by making delicate structural changes to the warhead scaffold. To this end, dipept
Externí odkaz:
https://doaj.org/article/60ad1902ed054cbca788414b67730366
Autor:
Patrick Müller, Collin Zimmer, Ariane Frey, Gideon Holzmann, Annabelle Carolin Weldert, Tanja Schirmeister
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1375 (2024)
Trypsin-like serine proteases are involved in many important physiological processes like blood coagulation and remodeling of the extracellular matrix. On the other hand, they are also associated with pathological conditions. The urokinase-pwlasminog
Externí odkaz:
https://doaj.org/article/c2e3cff487044b3abe06b3cd2c66ce76
Autor:
Patrick Müller, Mergim Meta, Jan Laurenz Meidner, Marvin Schwickert, Jessica Meyr, Kevin Schwickert, Christian Kersten, Collin Zimmer, Stefan Josef Hammerschmidt, Ariane Frey, Albin Lahu, Sergio de la Hoz-Rodríguez, Laura Agost-Beltrán, Santiago Rodríguez, Kira Diemer, Wilhelm Neumann, Florenci V. Gonzàlez, Bernd Engels, Tanja Schirmeister
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7226 (2023)
Covalent peptidomimetic protease inhibitors have gained a lot of attention in drug development in recent years. They are designed to covalently bind the catalytically active amino acids through electrophilic groups called warheads. Covalent inhibitio
Externí odkaz:
https://doaj.org/article/ff4da91785ec460c9d3be381dd2c4081
Autor:
Fabian Barthels, Stefan J. Hammerschmidt, Tim R. Fischer, Collin Zimmer, Elisabeth Kallert, Mark Helm, Christian Kersten, Tanja Schirmeister
Publikováno v:
HardwareX, Vol 11, Iss , Pp e00256- (2022)
Differential scanning fluorimetry (DSF) is a widely used biophysical technique with applications to drug discovery and protein biochemistry. DSF experiments are commonly performed in commercial real-time polymerase chain reaction (qPCR) thermal cycle
Externí odkaz:
https://doaj.org/article/d3a83ade95144ee980100bf1a9560551
Autor:
Carla Di Chio, Santo Previti, Fabiola De Luca, Marta Bogacz, Collin Zimmer, Annika Wagner, Tanja Schirmeister, Maria Zappalà, Roberta Ettari
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 14470 (2022)
Rhodesain is a cysteine protease that is crucial for the life cycle of Trypanosoma brucei rhodesiense, a parasite causing the lethal form of Human African Trypanosomiasis. CD24 is a recently developed synthetic inhibitor of rhodesain, characterized b
Externí odkaz:
https://doaj.org/article/edcfce7772a44794a27021fc6f6406c7
Autor:
Chatchakorn Eurtivong, Collin Zimmer, Tanja Schirmeister, Chutikarn Butkinaree, Rungroj Saruengkhanphasit, Worawat Niwetmarin, Somsak Ruchirawat, Avninder S. Bhambra
Publikováno v:
Molecular diversity.
Virtual screening a collection of ~ 25,000 ChemBridge molecule collection identified two nitrogenous heterocyclic molecules, 12 and 15, with potential dual inhibitory properties against trypanosomal cruzain and rhodesain cysteine proteases. Similarit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9115fd6393071bfa45cff65f3089947c
https://pubmed.ncbi.nlm.nih.gov/36617352
https://pubmed.ncbi.nlm.nih.gov/36617352
Autor:
Santo Previti, Roberta Ettari, Carla Di Chio, Jenny Legac, Marta Bogacz, Collin Zimmer, Tanja Schirmeister, Philip J. Rosenthal, Maria Zappalà
Publikováno v:
Bioorganic Chemistry. 137:106587
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2b3770508de16ab07e8d26240d029a6
https://doi.org/10.1016/j.bioorg.2023.106587
https://doi.org/10.1016/j.bioorg.2023.106587
Autor:
Annika Wagner, Sascha Jung, Natalie Fuchs, Philipp Klein, Ute Distler, Jochen Klein, Bernd Engels, Ute A. Hellmich, Stefan Tenzer, Fabian Barthels, Hans Joachim Räder, Patrick Johe, Waldemar Waigel, Tri Yuliani, Erika Diehl, Till Opatz, Collin Zimmer, Robert A. Zimmermann, Christian Kersten, Tanja Schirmeister, Jessica Meyr
Publikováno v:
Journal of Medicinal Chemistry. 64:12322-12358
Rhodesain is a major cysteine protease of Trypanosoma brucei rhodesiense, a pathogen causing Human African Trypanosomiasis, and a validated drug target. Recently, we reported the development of α-halovinylsulfones as a new class of covalent reversib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77d1b8e0a10409b4d2df95e00d985a0
https://doi.org/10.1021/acs.jmedchem.1c01002
https://doi.org/10.1021/acs.jmedchem.1c01002
Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain
Autor:
Santo Previti, Roberta Ettari, Elsa Calcaterra, Carla Di Chio, Rahul Ravichandran, Collin Zimmer, Stefan Hammerschmidt, Annika Wagner, Marta Bogacz, Sandro Cosconati, Tanja Schirmeister, Maria Zappalà
Publikováno v:
ACS medicinal chemistry letters. 13(7)
Human African Trypanosomiasis (HAT) is a neglected tropical disease widespread in sub-Saharan Africa. Rhodesain, a cysteine protease of Trypanosoma brucei rhodesiense, has been identified as a valid target for the development of anti-HAT agents. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7271d21b0301d852592b9187cb8dd482
https://pubmed.ncbi.nlm.nih.gov/35859868
https://pubmed.ncbi.nlm.nih.gov/35859868