Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Collin Y, Ewald"'
Autor:
Alina C. Teuscher, Cyril Statzer, Anita Goyala, Seraina A. Domenig, Ingmar Schoen, Max Hess, Alexander M. Hofer, Andrea Fossati, Viola Vogel, Orcun Goksel, Ruedi Aebersold, Collin Y. Ewald
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Dysfunctional extracellular matrices (ECM) contribute to aging and disease. Repairing dysfunctional ECM could potentially prevent age-related pathologies. Interventions promoting longevity also impact ECM gene expression. However, the role o
Externí odkaz:
https://doaj.org/article/c0e058623cd74bde8b2a47d1ff75c848
Autor:
Dan Xu, Jiangtao Zhou, Wei Long Soon, Ines Kutzli, Adrian Molière, Sabine Diedrich, Milad Radiom, Stephan Handschin, Bing Li, Lin Li, Shana J. Sturla, Collin Y. Ewald, Raffaele Mezzenga
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Food protein amyloid fibrils have superior technological, nutritional, sensorial, and physical properties compared to native monomers, but there is as yet insufficient understanding of their digestive fate and safety for wide consumption. By
Externí odkaz:
https://doaj.org/article/ce7f8e5aaaa94906b7e2d02f5de0ec33
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Collagen has been postulated to be the most abundant protein in our body, making up one-third of the total protein content in mammals. However, a direct assessment of the total collagen levels of an entire mammal to confirm this estimate is
Externí odkaz:
https://doaj.org/article/d30fe29a12b34a62ac52396303daf5a3
Autor:
Simon Marius Galyan, Collin Y. Ewald, Xavier Jalencas, Shyam Masrani, Selin Meral, Jordi Mestres
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Currently, there are no therapies available to modify the disease progression of Huntington’s disease (HD). Recent clinical trial failures of antisense oligonucleotide candidates in HD have demonstrated the need for new therapeutic approac
Externí odkaz:
https://doaj.org/article/e98c904096fc4a3d86ffffc25854d444
Autor:
Marco M. Ruckstuhl, Evelyne Bischof, Dana Blatch, Aliki Buhayer, Jörg Goldhahn, Edouard Battegay, Andre Tichelli, Collin Y. Ewald
Publikováno v:
Swiss Medical Weekly, Vol 153, Iss 6 (2023)
Breakthroughs in medical research in the last century have led to a significant extension of the human lifespan, resulting in a shift towards an elderly population worldwide. Due to the ongoing progress of global development towards elevated standard
Externí odkaz:
https://doaj.org/article/cb398a85dbc2425e98bbd8fd880315e1
Publikováno v:
Frontiers in Aging, Vol 4 (2023)
With an increasing aging population, the burden of age-related diseases magnifies. To alleviate this burden, geroprotection has been an area of intense research focus with the development of pharmacological interventions that target lifespan and/or h
Externí odkaz:
https://doaj.org/article/8ef0eca8eaef48b6861919f0f7509de7
Autor:
Cyril Statzer, Jin Meng, Richard Venz, Monet Bland, Stacey Robida-Stubbs, Krina Patel, Dunja Petrovic, Raffaella Emsley, Pengpeng Liu, Ianessa Morantte, Cole Haynes, William B. Mair, Alban Longchamp, Milos R. Filipovic, T. Keith Blackwell, Collin Y. Ewald
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors showed that, in C. elegans, inhibition of translation or mTORC1 increases ATF-4 expression independently of ISR signalling. ATF-4 promotes longevity by increasing hydrogen sulfide production by the enzyme CTH-2.
Externí odkaz:
https://doaj.org/article/0b2d369bb38048e0accd70b4ceb4ae16
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0294859 (2023)
The mammalian innate immune system is sex-dimorphic. Neutrophils are the most abundant leukocyte in humans and represent innate immunity's first line of defense. We previously found that primary mouse bone marrow neutrophils show widespread sex-dimor
Externí odkaz:
https://doaj.org/article/8eaf45c237534557bea23aeaa5747089
Autor:
Claudio Viecelli, Collin Y. Ewald
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Muscle mass and force are key for movement, life quality, and health. It is well established that resistance exercise is a potent anabolic stimulus increasing muscle mass and force. The response of a physiological system to resistance exercise is com
Externí odkaz:
https://doaj.org/article/1ffb1436209d40ca9bb089c4d64b3ec5
Autor:
Tinka Vidović, Collin Y. Ewald
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Aging is one of the largest risk factors for cancer, type 2 diabetes, osteoarthritis, cardiovascular diseases, and other age-related pathologies. Here, we give a detailed description of the interplay of chronic age-related pathologies with the remode
Externí odkaz:
https://doaj.org/article/e2ea52b4a0cf4905beba025e9a725ebf