Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Collin F. Regan"'
Autor:
Fabrice Pierre, Collin F. Regan, David M. Ryckman, Mustapha Haddach, Michael K. Schwaebe, Michael E. Jung
Publikováno v:
Synlett. 23:443-447
This paper reports the synthesis of various 5-halopyrimidine-4-carboxylic acid esters via the Minisci homolytic alkoxycarbonylation of 5-halopyrimidines. The reaction was found to be highly regioselective, allowing the one-step synthesis of useful am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6cd84a716460538e0a784b185ca3102
https://doi.org/10.1055/s-0031-1290136
https://doi.org/10.1055/s-0031-1290136
Autor:
Denis Drygin, Jerome Michaux, Fabrice Pierre, Diwata Macalino, Mustapha Haddach, Cosmin Borsan, David M. Ryckman, Collin F. Regan, Sean O'Brien, Pauline Kerdoncuff, Eric Stefan, Adam Siddiqui-Jain, Peter C. Chua, Michael K. Schwaebe, William G. Rice
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:45-48
Protein kinase CK2 is a potential drug target for many diseases including cancer and inflammation disorders. The crystal structure of clinical candidate CX-4945 1 with CK2 revealed an indirect interaction with the protein through hydrogen bonding bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3160afd93213ef74a7ceb68cacac8b
https://doi.org/10.1016/j.bmcl.2011.11.087
https://doi.org/10.1016/j.bmcl.2011.11.087
Autor:
Denis Drygin, Marie-Claire Chevrel, Anne‐Sophie Nedellec, Collin F. Regan, Diwata Macalino, Mustapha Haddach, Sean O'Brien, Adam Siddiqui-Jain, Kenna Anderes, Fabrice Pierre, Eric Stefan, Nicole Streiner, David M. Ryckman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6687-6692
A novel class of pan-Pim kinase inhibitors was designed by modifying the CK2 inhibitor CX-4945. Introduction of a triazole or secondary amide functionality on the C-7 position and 2'-halogenoanilines on C-5 resulted in potent inhibitors of the Pim-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a38017ad454d36e6736d1c2acfc4a8d
https://doi.org/10.1016/j.bmcl.2011.09.059
https://doi.org/10.1016/j.bmcl.2011.09.059
Autor:
Fabio C. Tucci, Martin W. Rowbottom, Susan K. Sullivan, R. Scott Struthers, Yang Sai, Collin F. Regan, Shelby Reijmers, Chen Chen, Zhiqiang Guo, Qiu Xie, Dongpei Wu, Yun-Fei Zhu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3685-3690
SAR studies of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists resulted in potent compounds. The best compound from the series had a binding affinity of 2 nM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b37e6872c5e7cde2a7d2bace282ab30
https://doi.org/10.1016/j.bmcl.2005.05.038
https://doi.org/10.1016/j.bmcl.2005.05.038
Publikováno v:
Angewandte Chemie. 125:2114-2116
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b458aa93a0aafc01998b5db343ed3e4d
https://doi.org/10.1002/ange.201208294
https://doi.org/10.1002/ange.201208294
ChemInform Abstract: Se-Phenyl Prop-2-eneselenoate: An Ethylene Equivalent for Diels-Alder Reactions
Publikováno v:
ChemInform. 44
others. [7] In an approach to the total synthesis of brasilicardin A, 1, [8] we needed an ethylene equivalent for the preparation of the C ring. Since many of the known ethylene equivalents did not work well for various reasons, we decided to develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5637dfcc0f39cea611fbfefebe869fff
https://doi.org/10.1002/chin.201330031
https://doi.org/10.1002/chin.201330031
Publikováno v:
Angewandte Chemie (International ed. in English). 52(7)
others. [7] In an approach to the total synthesis of brasilicardin A, 1, [8] we needed an ethylene equivalent for the preparation of the C ring. Since many of the known ethylene equivalents did not work well for various reasons, we decided to develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6fad3c92295e72a3b064916ac67cf3
https://pubmed.ncbi.nlm.nih.gov/23315953
https://pubmed.ncbi.nlm.nih.gov/23315953
Autor:
Collin F. Regan, Mustapha Haddach, Fabrice Pierre, Michael E. Jung, Michael K. Schwaebe, David M. Ryckman
Publikováno v:
ChemInform. 43
A convenient one-pot procedure is developed for the synthesis of the title compounds, where ester (II) is found to be optimal for the process.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::953752753cf8b9b8a5ed7f841bc1ec35
https://doi.org/10.1002/chin.201223170
https://doi.org/10.1002/chin.201223170
Autor:
Collin F. Regan, Sean O'Brien, Denis Drygin, Adam Siddiqui-Jain, David M. Ryckman, Diwata Macalino, William G. Rice, Mustapha Haddach, Nicole Streiner, Marie-Claire Chevrel, Fabrice Pierre
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(9)
A novel family of potent dual inhibitors of CK2 and the Pim kinases was discovered by modifying the scaffolds of tricyclic Pim inhibitors. Several analogs were active at single digit nanomolar IC50 values against CK2 and the Pim isoforms Pim-1 and Pi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d40261592c3182a8bd646f2cefe25c5
https://pubmed.ncbi.nlm.nih.gov/22460033
https://pubmed.ncbi.nlm.nih.gov/22460033
Autor:
Tomas Szabo, James R. McCarthy, Dimitri E. Grigoriadis, Collin F. Regan, Brian Dyck, Dragan Marinkovic, Xiaohu Zhang, Michael K. Schwaebe, Mustapha Haddach, Raymond S. Gross, Manisha Moorjani, John Saunders, John P. Williams, Haig Bozigian, Zhiqiang Guo, Ta Kung Chen
Publikováno v:
Journal of medicinal chemistry. 48(12)
Two new classes of tricyclic-based corticotropin-releasing factor (CRF(1)) receptor-1 antagonists were designed by constraining known 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine ligands. Pyrrole- and pyrazole-based molecules 19g and 22a,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562644dda2778e4f347510798cd7d767
https://pubmed.ncbi.nlm.nih.gov/15943483
https://pubmed.ncbi.nlm.nih.gov/15943483