Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer.

Autor: Dashzeveg NK; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Jia Y; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Zhang Y; Department of Medicine, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Gerratana L; Department of Medicinal Oncology, Centro di Riferimento Oncologico di Aviano (CRO), IRCCS, Aviano, Italy., Patel P; Quantitative Data Science Core, Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Shajahan A; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia., Dandar T; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Ramos EK; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Almubarak HF; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Adorno-Cruz V; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Taftaf R; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Schuster EJ; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Scholten D; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Sokolowski MT; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Reduzzi C; Department of Medicine, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Division of Hematology-Oncology, Department of Medicine, Weill Cornell Medicine, New York, New York., El-Shennawy L; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Hoffmann AD; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Manai M; Department of Medicine, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Zhang Q; Department of Medicine, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., D'Amico P; Department of Medicine, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Azadi P; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia., Colley KJ; Department of Biochemistry and Molecular Genetics, University of Illinois Chicago, Chicago, Illinois., Platanias LC; Department of Medicine, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Shah AN; Department of Medicine, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Gradishar WJ; Department of Medicine, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Cristofanilli M; Department of Medicine, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Division of Hematology-Oncology, Department of Medicine, Weill Cornell Medicine, New York, New York.; Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Muller WA; Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio., Cobb BA; Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois., Liu H; Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Department of Medicine, Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Publikováno v: Cancer discovery [Cancer Discov] 2023 Sep 06; Vol. 13 (9), pp. 2050-2071.

ST8Sia2 polysialyltransferase protects against infection by Trypanosoma cruzi.

Autor: Barboza, Bruno Rafael¹ (AUTHOR), Macedo-da-Silva, Janaina¹ (AUTHOR), Silva, Lays Adrianne Mendonça Trajano¹ (AUTHOR), Gomes, Vinícius de Morais¹ (AUTHOR), Santos, Deivid Martins¹ (AUTHOR), Marques-Neto, Antônio Moreira¹ (AUTHOR), Mule, Simon Ngao¹ (AUTHOR), Angeli, Claudia Blanes¹ (AUTHOR), Borsoi, Juliana² (AUTHOR), Moraes, Carolina Borsoi³ (AUTHOR), Moutinho-Melo, Cristiane^4,5 (AUTHOR), Mühlenhoff, Martina⁶ (AUTHOR), Colli, Walter⁷ (AUTHOR), Marie, Suely Kazue Nagashi⁸ (AUTHOR), Pereira, Lygia da Veiga² (AUTHOR), Alves, Maria Julia Manso⁷ (AUTHOR), Palmisano, Giuseppe^1,9 (AUTHOR) palmisano.gp@usp.br

Publikováno v: PLoS Neglected Tropical Diseases. 9/25/2024, Vol. 18 Issue 9, p1-33. 33p.

Autopolysialylation of polysialyltransferases is required for polysialylation and polysialic acid chain elongation on select glycoprotein substrates.

Autor: Bhide GP; From the Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607., Zapater JL; From the Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607., Colley KJ; From the Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607 karenc@uic.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2018 Jan 12; Vol. 293 (2), pp. 701-716. Date of Electronic Publication: 2017 Nov 28.

Sialylation of N-glycans: mechanism, cellular compartmentalization and function.

Autor: Bhide GP; Department of Biochemistry and Molecular Genetics, College of Medicine, The University of Illinois at Chicago, 900 S. Ashland Avenue, MC669, Chicago, IL, 60607, USA., Colley KJ; Department of Biochemistry and Molecular Genetics, College of Medicine, The University of Illinois at Chicago, 900 S. Ashland Avenue, MC669, Chicago, IL, 60607, USA. karenc@uic.edu.

Publikováno v: Histochemistry and cell biology [Histochem Cell Biol] 2017 Feb; Vol. 147 (2), pp. 149-174. Date of Electronic Publication: 2016 Dec 14.

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