Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Collet Dandara"'
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 3, Pp n/a-n/a (2024)
Abstract Tamoxifen, a selective estrogen receptor modulator, is used to treat hormone receptor‐positive breast cancer. Tamoxifen acts as a prodrug, with its primary therapeutic effect mediated by its principal metabolite, endoxifen. However, tamoxi
Externí odkaz:
https://doaj.org/article/f5697be1e06e48b78a36c8b681f42f35
Autor:
Jonathan N. Katsukunya, Erika Jones, Nyarai D. Soko, Dirk Blom, Phumla Sinxadi, Brian Rayner, Collet Dandara
Publikováno v:
Journal of Personalized Medicine, Vol 14, Iss 7, p 664 (2024)
Resistant hypertension (RHTN) prevalence ranges from 4 to 19% in Africa. There is a paucity of data on the role of genetic variation on RHTN among Africans. We set out to investigate the role of polymorphisms in ABCB1, ADRB1, CYP3A4, CYP3A5, NEDD4L,
Externí odkaz:
https://doaj.org/article/5351a36df8864fda8ee9b2000747ba84
Autor:
Prisca K. Thami, Wonderful T. Choga, Collet Dandara, Stephen J. O’Brien, Myron Essex, Simani Gaseitsiwe, Emile R. Chimusa
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
HIV infection continues to be a major global public health issue. The population heterogeneity in susceptibility or resistance to HIV-1 and progression upon infection is attributable to, among other factors, host genetic variation. Therefore, identif
Externí odkaz:
https://doaj.org/article/81eba73213784e279e6a6832680e1247
Autor:
Oppah Kuguyo, Nyasha Chambwe, Charles F. B. Nhachi, Nomsa Tsikai, Collet Dandara, Alice Matimba
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Research infrastructures such as biorepositories are essential to facilitate genomics and its growing applications in health research and translational medicine in Africa. Using a cervical cancer cohort, this study describes the e
Externí odkaz:
https://doaj.org/article/6e4775b533804603b464cbbfac7334c8
Publikováno v:
Frontiers in Allergy, Vol 4 (2023)
Asthma is a common chronic condition in children and in an African setting is often highly prevalent in urban areas as compared to rural areas. Asthma is a heritable disease and the genetic risk is often exacerbated by unique localised environmental
Externí odkaz:
https://doaj.org/article/c5b367465cbb465f9de51015cd378936
Autor:
Jonathan N. Katsukunya, Nyarai D. Soko, Jashira Naidoo, Brian Rayner, Dirk Blom, Phumla Sinxadi, Emile R. Chimusa, Michelle Dandara, Kevin Dzobo, Erika Jones, Collet Dandara
Publikováno v:
International Journal of Hypertension, Vol 2023 (2023)
In Africa, the burden of hypertension has been rising at an alarming rate for the last two decades and is a major cause for cardiovascular disease (CVD) mortality and morbidity. Hypertension is characterised by elevated blood pressure (BP) ≥ 140/90
Externí odkaz:
https://doaj.org/article/013083cf4127412a82b975bde3918c17
Autor:
Nyarai Desiree Soko, Sarudzai Muyambo, Michelle T. L. Dandara, Elizabeth Kampira, Dirk Blom, Erika S. W. Jones, Brian Rayner, Delva Shamley, Phumla Sinxadi, Collet Dandara
Publikováno v:
Journal of Personalized Medicine, Vol 13, Iss 8, p 1185 (2023)
Pharmacogenomics may improve patient care by guiding drug selection and dosing; however, this requires prior knowledge of the pharmacogenomics of drugs commonly used in a specific setting. The aim of this study was to identify a preliminary set of ph
Externí odkaz:
https://doaj.org/article/51c99283c49949e8821dd74a16fbb968
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/94f0677d1df44537bd7a3a2ec93c188e
Autor:
Kevin Dzobo, Collet Dandara
Publikováno v:
Biomimetics, Vol 8, Iss 2, p 146 (2023)
The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular processes, the extracellular matrix has been shown to have diverse com
Externí odkaz:
https://doaj.org/article/e33d2632ebb6497f8a1d335d8fd0e4bd
Autor:
Doreen Z. Mhandire, Kudakwashe Mhandire, Mulalo Magadze, Ambroise Wonkam, Andre P. Kengne, Collet Dandara
Publikováno v:
BMC Medical Genetics, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract Background Maternal cytomegalovirus (CMV) infection and/or reactivation in pregnancy is associated with a myriad of adverse infant outcomes. However, the role of host genetic polymorphisms in modulating maternal CMV status is inconclusive. T
Externí odkaz:
https://doaj.org/article/9295c5ac947f4d3e8f00fd47ea887aca