Výsledky vyhledávání - "Colleen Scheitrum"

Cyclic Adenosine Monophosphate Phosphodiesterase Type 4 Protects Against Atrial Arrhythmias

Autor: Colleen Scheitrum, Catherine Rucker-Martin, Rodolphe Fischmeister, Patrick Donzeau-Gouge, Christoph Maack, Moses Xie, Marco Conti, Jérôme Leroy, Leif Hove-Madsen, Cristina E. Molina, Ignacio Verde, Wito Richter, Grégoire Vandecasteele, Illkyu-Oliver Lee, Anna Llach

Publikováno v: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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Objectives This study was designed to examine whether a cyclic adenosine monophosphate (cAMP) phosphodiesterase (PDE), PDE4, is expressed in human atrium and contributes to the control of electrical stability. Background Atrial fibrillation is accomp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3dbe4ab4993b7f55347acd5fd59243

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Inactivation of Multidrug Resistance Proteins Disrupts Both Cellular Extrusion and Intracellular Degradation of cAMP

Autor: Moses Xie, Thomas C. Rich, Colleen Scheitrum, Wito Richter, Marco Conti

Publikováno v: Molecular Pharmacology. 80:281-293

In addition to xenobiotics and several other endogenous metabolites, multidrug-resistance proteins (MRPs) extrude the second-messenger cAMP from various cells. Pharmacological and/or genetic inactivation of MRPs has been shown to augment intracellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b76545260f11c6fde792fbe9307cd95
https://doi.org/10.1124/mol.111.071134

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The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s)

Autor: Marco Conti, Elise Blanchard, Moses Xie, Colleen Scheitrum, Tao Lei, Wito Richter, Brigitte E. Blackman, Delphine Mika

Publikováno v: The Biochemical journal, vol 459, iss 3

PDE4s (type 4 cyclic nucleotide phosphodiesterases) are divided into long and short forms by the presence or absence of conserved N-terminal domains termed UCRs (upstream conserved regions). We have shown previously that PDE4D2, a short variant, is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8701347d290e4e571977fcb9459bc9cf
https://escholarship.org/uc/item/4qr0k0vf

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Anchored PDE4 controls CFTR conductance in normal and cystic fibrosis airway epithelia (1181.3)

Autor: Walter E. Finkbeiner, Elise Blanchard, Marco Conti, Dieter C. Gruenert, Moses Xie, Colleen Scheitrum, Lorna Zlock, Alan S. Verkman, Anna Lao, Wan Namkung, Wito Richter, Delphine Mika

Publikováno v: The FASEB Journal. 28

Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) that impair its expression or function. PKA phosphorylation is the ma...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a949f4d9d417fdc1aa09b30a20a95752
https://doi.org/10.1096/fasebj.28.1_supplement.1181.3

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Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia

Autor: Wan Namkung, Walter E. Finkbeiner, Delphine Mika, Moses Xie, Dieter C. Gruenert, Marco Conti, Wito Richter, Alan S. Verkman, Anna Lao, Lorna Zlock, Elise Blanchard, Colleen Scheitrum

Cystic fibrosis (CF) is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) that impair its expression and/or chloride channel function. Here, we provide evidence that type 4 cyclic nucleotide phosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6c3f5a7af5032a175b3cbfcb477a48
https://europepmc.org/articles/PMC3898646/

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Phosphodiesterase 4B in the cardiac L-type Ca 2+ channel complex regulates Ca 2+ current and protects against ventricular arrhythmias in mice

Autor: Colleen Scheitrum, Wito Richter, Marco Conti, Philippe Mateo, Moses Xie, Delphine Mika, Florence Lefebvre, Flavien Charpentier, Julia Schittl, Rodolphe Fischmeister, Ruth E. Westenbroek, Jérôme Leroy, Grégoire Vandecasteele, Liliana R.V. Castro, Aniella Abi-Gerges, William A. Catterall

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 2011, 121 (7), pp.2651-2661. ⟨10.1172/JCI44747⟩

β-Adrenergic receptors (β-ARs) enhance cardiac contractility by increasing cAMP levels and activating PKA. PKA increases Ca2+-induced Ca2+ release via phosphorylation of L-type Ca2+ channels (LTCCs) and ryanodine receptor 2. Multiple cyclic nucleot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aac8285a825c5c166d1ec0ab76242fb
https://hal.archives-ouvertes.fr/hal-02940351/document

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Conserved expression and functions of PDE4 in rodent and human heart

Autor: Moses Xie, Colleen Scheitrum, Judith Krall, Matthew A. Movsesian, Marco Conti, Wito Richter

Publikováno v: Richter, Wito; Xie, Moses; Scheitrum, Colleen; Krall, Judith; Movsesian, Matthew A.; & Conti, Marco. (2011). Conserved expression and functions of PDE4 in rodent and human heart. Basic Research in Cardiology, 106(2), pp 249-262. doi: 10.1007/s00395-010-0138-8. Retrieved from: http://www.escholarship.org/uc/item/75c430rd
Basic research in cardiology, vol 106, iss 2
Basic Research in Cardiology

PDE4 isoenzymes are critical in the control of cAMP signaling in rodent cardiac myocytes. Ablation of PDE4 affects multiple key players in excitation–contraction coupling and predisposes mice to the development of heart failure. As little is known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7335ba0006537f9a4ad0583c971bfb
http://www.escholarship.org/uc/item/75c430rd

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Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice

Autor: Jérôme, Leroy, Wito, Richter, Delphine, Mika, Liliana R V, Castro, Aniella, Abi-Gerges, Moses, Xie, Colleen, Scheitrum, Florence, Lefebvre, Julia, Schittl, Philippe, Mateo, Ruth, Westenbroek, William A, Catterall, Flavien, Charpentier, Marco, Conti, Rodolphe, Fischmeister, Grégoire, Vandecasteele

Publikováno v: The Journal of clinical investigation. 121(7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::494f6ca9944ea936995161548808d169
https://pubmed.ncbi.nlm.nih.gov/21670503

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