Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Colleen S. Kondo"'
ATP triggers a robust intracellular [Ca2+]-mediated signalling pathway in human synovial fibroblasts
Autor:
Robert T. Szerencsei, Darrell D. Belke, Wayne R. Giles, T. Y. Kim, Paul P. M. Schnetkamp, Colleen S. Kondo, Kenneth W. Spitzer, Ali H. Jalloul, Umberto Banderali, Robert B. Clark
Publikováno v:
Experimental Physiology. 103:1101-1122
New findings What is the central question of this study? What are the main [Ca2+ ]i signalling pathways activated by ATP in human synovial fibroblasts? What is the main finding and its importance? In human synovial fibroblasts ATP acts through a link
Publikováno v:
The Journal of Physiology. 589:5071-5089
Potassium channels that regulate resting membrane potential (RMP) of human articular chondrocytes (HACs) of the tibial joint maintained in short-term (0-3 days) non-confluent cell culture were studied using patch-clamp techniques. Quantitative PCR sh
Autor:
Jason H. Haga, Colleen S. Kondo, Wayne R. Giles, Lee K. Landeen, Betty S. Hu, Dorothy A. Dederko, Nakon Aroonsakool
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 294:H736-H749
Sphingosine-1-phosphate (S1P) induces a transient bradycardia in mammalian hearts through activation of an inwardly rectifying K+ current ( IKACh) in the atrium that shortens action potential duration (APD) in the atrium. We have investigated probabl
Autor:
David L. Severson, James C. Cross, Lin Su, Anders Nygren, Colleen Geary-Joo, Stanley Kunnathu, Wayne R. Giles, Michael Hesse, Frances L. Allen, Colleen S. Kondo, Robert B. Clark
Publikováno v:
Cardiovascular Research. 75:498-509
Objective: Dilated cardiomyopathy (DCM) leads to dilation of the cardiac chambers and congestive heart failure. Recent reports have associated mutations in the SCN5A gene, which codes for the major cardiac sodium channel Nav1.5, with DCM. Although DC
Autor:
Jussi T. Koivumäki, Darrell D. Belke, Mary M. Maleckar, Wayne R. Giles, Paul W.M. Fedak, Robert B. Clark, Colleen S. Kondo
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Frontiers in Physiology
Frontiers in Physiology
In the mammalian heart fibroblasts have important functional roles in both healthy conditions and diseased states. During pathophysiological challenges, a closely related myofibroblast cell population emerges, and can have distinct, significant roles
Autor:
Anders Nygren, Robert B. Clark, Colleen S. Kondo, Francis X. Witkowski, Darrell D. Belke, Wayne R. Giles
Publikováno v:
Annals of Biomedical Engineering. 28:958-967
A custom-made apparatus based on a charge-coupled-device camera has been used to monitor changes in fluorescence from Langendorff-perfused adult mouse hearts stained with a voltage-sensitive dye, di-4-ANEPPS. With this approach it is possible to moni
Publikováno v:
Circulation Research. 79:79-85
Expression of cardiac transient outward current and inwardly rectifying K + current is age dependent. However, little is known about age-related changes in cardiac delayed rectifier K + current (I K , with rapidly and slowly activating components, I
Autor:
Bryan J. Heard, Quinn Harris, Colleen S. Kondo, Jonathan Seto, Roman Krawetz, Kate O'Brien, David A. Hart, Poh S. Lee
Publikováno v:
Stem cells (Dayton, Ohio). 31(10)
Osteoarthritis (OA) is a multifactorial, often progressive, painful disease. OA often progresses with an apparent irreversible loss of articular cartilage, exposing underlying bone, resulting in pain and loss of mobility. This cartilage loss is thoug
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 266:H2327-H2333
To determine which tissues limit left ventricular (LV) filling during the early neonatal period we studied LV end-diastolic pressure-diameter relationships in two groups of halothane-anesthetized lambs (five 1-h-old lambs and six 2- to 17-day-old lam
Autor:
Barry S. Brown, Darrell D. Belke, Wayne R. Giles, Bartholomew J Votta, Colleen S. Kondo, Robert B. Clark, Noriyuki Hatano, Sanjay Kumar
Publikováno v:
Channels (Austin, Tex.). 4(3)
Membrane currents and resting potential of isolated primary mouse articular chondrocytes maintained in monolayer cell culture for 1-9 days were recorded using patch clamp methods. Quantitative RT-PCR showed that the most abundantly expressed transcri