Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Colleen R. Reczek"'
Autor:
Daniela Georgieva, Ning Wang, Angelo Taglialatela, Stepan Jerabek, Colleen R. Reczek, Pei Xin Lim, Julie Sung, Qian Du, Michiko Horiguchi, Maria Jasin, Alberto Ciccia, Richard Baer, Dieter Egli
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114006- (2024)
Summary: Reprogramming to pluripotency is associated with DNA damage and requires the functions of the BRCA1 tumor suppressor. Here, we leverage separation-of-function mutations in BRCA1/2 as well as the physical and/or genetic interactions between B
Externí odkaz:
https://doaj.org/article/44e405bad36b4df4b62d48f8744cbc42
Autor:
Adam Naguib, Grinu Mathew, Colleen R. Reczek, Kaitlin Watrud, Alexandra Ambrico, Tali Herzka, Irene Casanova Salas, Matthew F. Lee, Nour El-Amine, Wu Zheng, M. Emilia Di Francesco, Joseph R. Marszalek, Darryl J. Pappin, Navdeep S. Chandel, Lloyd C. Trotman
Publikováno v:
Cell Reports, Vol 23, Iss 1, Pp 58-67 (2018)
Summary: A hallmark of advanced prostate cancer (PC) is the concomitant loss of PTEN and p53 function. To selectively eliminate such cells, we screened cytotoxic compounds on Pten−/−;Trp53−/− fibroblasts and their Pten-WT reference. Highly se
Externí odkaz:
https://doaj.org/article/ef92114328e64222bc2c836f7460a8f4
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 451-459 (2016)
Hypoxia-inducible factors (HIFs) are crucial for cellular and organismal adaptation to hypoxia. The mitochondrial respiratory chain is the largest consumer of oxygen in most mammalian cells; however, it is unknown whether the respiratory chain is nec
Externí odkaz:
https://doaj.org/article/d991e3c505c340fd92157ca6287bc356
Autor:
Leah K. Billingham, Joshua S. Stoolman, Karthik Vasan, Arianne E. Rodriguez, Taylor A. Poor, Marten Szibor, Howard T. Jacobs, Colleen R. Reczek, Aida Rashidi, Peng Zhang, Jason Miska, Navdeep S. Chandel
Publikováno v:
Nature Immunology. 23:692-704
The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and its dysregulation underlies many chronic diseases. Mitochondria have been implicated as regulators of the NLRP3 inflammasome through several mechanisms including gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932b18ffa6ea54322fdc555b653b6a51
https://doi.org/10.1038/s41590-022-01185-3
https://doi.org/10.1038/s41590-022-01185-3
Autor:
Navdeep S. Chandel, Marie Werner, Colleen R. Reczek, Inmaculada Martínez-Reyes, G. R. Scott Budinger, Hyewon Kong, Elizabeth M. Steinert, Gregory S. McElroy, Samuel E. Weinberg, Peng Gao, Karthik Vasan, Raul Piseaux, Hermon Kihshen, Luzivette Robles Cardona
Publikováno v:
Nature
The mitochondrial electron transport chain (ETC) is necessary for tumour growth1–6 and its inhibition has demonstrated anti-tumour efficacy in combination with targeted therapies7–9. Furthermore, human brain and lung tumours display robust glucos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3bd8b32e1b5326cefd33fbc4c61721
http://europepmc.org/articles/PMC7486261
http://europepmc.org/articles/PMC7486261
Autor:
Dongju Park, Mehdi Gharghabi, Colleen R. Reczek, Rebecca Plow, Charles Yungvirt, C. Marcelo Aldaz, Kay Huebner
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3729
Wwox-deficient human cells show elevated homologous recombination, leading to resistance to killing by double-strand break-inducing agents. Human Wwox binds to the Brca1 981-PPLF-984 Wwox-binding motif, likely blocking the pChk2 phosphorylation site
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1b0271180982fbb37bbff6ffd02ae7
https://pubmed.ncbi.nlm.nih.gov/35409089
https://pubmed.ncbi.nlm.nih.gov/35409089
Autor:
Sangwook Jung, Pavel I. Zimin, Christian B. Woods, Ernst-Bernhard Kayser, Dominik Haddad, Colleen R. Reczek, Ken Nakamura, Jan-Marino Ramirez, Margaret M. Sedensky, Philip G. Morgan
Publikováno v:
Current biology : CB. 32(14)
The mechanisms of volatile anesthetic action remain among the most perplexing mysteries of medicine. Across phylogeny, volatile anesthetics selectively inhibit mitochondrial complex I, and they also depress presynaptic excitatory signaling. To explor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c86263aff6603b64b14e70585da160ab
https://pubmed.ncbi.nlm.nih.gov/35882199
https://pubmed.ncbi.nlm.nih.gov/35882199
Autor:
Leah K, Billingham, Joshua S, Stoolman, Karthik, Vasan, Arianne E, Rodriguez, Taylor A, Poor, Marten, Szibor, Howard T, Jacobs, Colleen R, Reczek, Aida, Rashidi, Peng, Zhang, Jason, Miska, Navdeep S, Chandel
Publikováno v:
Nature immunology. 23(5)
The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and its dysregulation underlies many chronic diseases. Mitochondria have been implicated as regulators of the NLRP3 inflammasome through several mechanisms including gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::16b2ad340721fdb2238a01807725a2f3
https://pubmed.ncbi.nlm.nih.gov/35484409
https://pubmed.ncbi.nlm.nih.gov/35484409
Autor:
Timothy C. Wang, Navdeep S. Chandel, Hyewon Kong, Elizabeth M. Steinert, Gregory S. McElroy, Colleen R. Reczek, David M. Sabatini
Publikováno v:
Science Advances
Mitochondrial complex I inhibition in the presence of a mito-antioxidant induces reductive stress, ISR, and cancer cell death.
Mitochondria-derived reactive oxygen species (mROS) are required for the survival, proliferation, and metastasis of ca
Mitochondria-derived reactive oxygen species (mROS) are required for the survival, proliferation, and metastasis of ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b7f78bfbc355c977ba7e9e393ea6d3
https://doi.org/10.1126/sciadv.abb7272
https://doi.org/10.1126/sciadv.abb7272
Autor:
Peng Gao, Colleen R. Reczek, Hyewon Kong, David M. Sabatini, Kıvanç Birsoy, Inmaculada Martínez-Reyes, Timothy C. Wang, Navdeep S. Chandel
Publikováno v:
PMC
Nature chemical biology
Nature chemical biology
Paraquat, a herbicide linked to Parkinson's disease, generates reactive oxygen species (ROS), which causes cell death. Because the source of paraquat-induced ROS production remains unknown, we conducted a CRISPR-based positive-selection screen to ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68848f88a5f371d1b04a1bcaa545172
https://doi.org/10.1038/nchembio.2499
https://doi.org/10.1038/nchembio.2499