Výsledky vyhledávání - "Colleen R. Maier"

Data from Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis

Autor: Phillip A. Dennis, Stephen D. Fox, Shigeru Kawabata, Colleen R. Maier, Jose R. Mercado, Regan M. Memmott

Activation of the mammalian target of rapamycin (mTOR) pathway is an important and early event in tobacco carcinogen–induced lung tumorigenesis, and therapies that target mTOR could be effective in the prevention or treatment of lung cancer. The bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752d6f71ad6de8279318b24f69778677
https://doi.org/10.1158/1940-6207.c.6544863.v1

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Nicotine Does Not Enhance Tumorigenesis in Mutant K-Ras–Driven Mouse Models of Lung Cancer

Autor: M. Christine Hollander, Phillip A. Dennis, R. Ilona Linnoila, Irem Dogan, Evthokia Hobbs, Colleen R. Maier

Publikováno v: Cancer Prevention Research. 4:1743-1751

Smoking is the leading cause of preventable cancer deaths in the United States. Nicotine replacement therapies (NRT) have been developed to aid in smoking cessation, which decreases lung cancer incidence. However, the safety of NRT is controversial b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f4916deee6ae046535c0060cde32a47
https://doi.org/10.1158/1940-6207.capr-11-0365

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A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice

Autor: Andrew D. Patterson, Colleen R. Maier, Xinxin Ding, M. Christine Hollander, Phillip A. Dennis, Xin Zhou

Publikováno v: Carcinogenesis. 32:1279-1284

Lung tumors from smokers as well as lung tumors from mice exposed to tobacco carcinogens such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), often carry mutations in K-ras, which activates downstream-signaling pathways such as PI3K/AKT/mTOR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea53ff54bc22cdb2b35ce6f3602c5b02
https://doi.org/10.1093/carcin/bgr097

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Metformin prevents tobacco carcinogen--induced lung tumorigenesis

Autor: Shigeru Kawabata, Jose Mercado, Stephen D. Fox, Colleen R. Maier, Phillip A. Dennis, Regan M. Memmott

Publikováno v: Cancer prevention research (Philadelphia, Pa.). 3(9)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311e35b6c3c0363a7d5615d9009c7e34
https://pubmed.ncbi.nlm.nih.gov/20810671

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Abstract 1336: Nicotine does not promote tumor growth in preclinical mouse models of lung cancer

Autor: Colleen R. Maier, Phillip A. Dennis, M. Christine Hollander

Publikováno v: Cancer Research. 71:1336-1336

Nicotine replacement therapy (NRT) is a popular and effective regimen for the cessation of smoking. Expanded use of NRT is controversial based on preclinical studies that show that nicotine activates signaling pathways that promote cellular survival

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::605c9f1f8711caa826519999835cd40f
https://doi.org/10.1158/1538-7445.am2011-1336

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Abstract 614: Efficacy of metformin in two mouse models of Li-Fraumeni syndrome

Autor: Colleen R. Maier, Matthew Dallos, Shigeru Kawabata, Regan M. Memmott, Ajaikumar B. Kunnumakkara, Brendan J. Quinn, Joell J. Gills, Phillip A. Dennis, Christine M. Hollander

Publikováno v: Cancer Research. 71:614-614

Li-Fraumeni Syndrome (LFS) is a rare autosomal hereditary disorder that is commonly associated with germline mutations in the TP53 gene. People with LFS are at high risk to develop a wide range of malignancies including breast cancer, brain tumors, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd7d11b6420a57d7bb9f5f68734a96f9
https://doi.org/10.1158/1538-7445.am2011-614

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