Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Colleen M. McDowell"'
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Background Elevated intraocular pressure (IOP) is a major risk factor for the development and progression of primary open angle glaucoma and is due to trabecular meshwork (TM) damage. Here, we investigate the role of an endogenous Toll-like
Externí odkaz:
https://doaj.org/article/2258a098015b423389a505186f84d995
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Primary open-angle glaucoma is one of the leading causes of blindness worldwide. With limited therapeutics targeting the pathogenesis at the trabecular meshwork (TM), there is a great need for identifying potential new targets. Recent evidence has im
Externí odkaz:
https://doaj.org/article/1372d52879814e8ca2e3ddf8e4099a22
Autor:
Christine M. Sorenson, Yong-Seok Song, Ismail S. Zaitoun, Shoujian Wang, Barbara A. Hanna, Soesiawati R. Darjatmoko, Zafer Gurel, Debra L. Fisk, Colleen M. McDowell, Ryan M. McAdams, Nader Sheibani
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Adenosine receptors (AR) are widely expressed in a variety of tissues including the retina and brain. They are involved in adenosine-mediated immune responses underlying the onset and progression of neurodegenerative diseases. The expression of AR ha
Externí odkaz:
https://doaj.org/article/02459f7142584f92902c60fc09be27df
Autor:
Stacy Curry, Sherri L Harris, Timur A. Mavlyutov, Colleen M McDowell, Anil K. Chauhan, Amanda Lenell Roberts, Tanisha E Perlmutter
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Elevated intraocular pressure (IOP) is a major risk factor for the development and progression of primary open angle glaucoma and is due to trabecular meshwork (TM) damage, which leads to impaired aqueous humor outflow. Here, we explore a novel molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1256c0d7d79d873f7b1ab5fb09742861
http://link.springer.com/article/10.1038/s41598-020-66756-6
http://link.springer.com/article/10.1038/s41598-020-66756-6
Autor:
Timur A, Mavlyutov, Megan S, Kuhn, Samer E, Bilal, Michael L, De Ieso, Anil K, Chauhan, W Daniel, Stamer, Colleen M, McDowell
Publikováno v:
Experimental Eye Research. 225:109249
Previously we identified B6.EDA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6204380db9ad1bca6a5c16cb8ea3e473
https://doi.org/10.1016/j.exer.2022.109249
https://doi.org/10.1016/j.exer.2022.109249
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0237932 (2020)
PLoS ONE, Vol 15, Iss 8, p e0237932 (2020)
Increased deposition of fibronectin fibrils containing EDA+fibronectin by TGFβ2 is thought to be involved in the reduction of aqueous humor outflow across the trabecular meshwork (TM) of the eye and the elevation in intraocular pressure (IOP) observ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77cb4690bae42176ad7920c456af8ffc
http://europepmc.org/articles/PMC7444551
http://europepmc.org/articles/PMC7444551
Publikováno v:
Journal of Visualized Experiments.
There is a current unmet need for a new preclinical human model that can target disease etiology ex vivo using intracranial pressure (ICP) and intraocular pressure (IOP) which can identify various pathogenic paradigms related to the glaucoma pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8edadb8787f45abee61e28fb5fb9eb57
https://doi.org/10.3791/61006-v
https://doi.org/10.3791/61006-v
Publikováno v:
J Ocul Pharmacol Ther
Purpose: Transforming growth factor-β2 (TGFβ2) and Toll-like receptor 4 (TLR4) crosstalk have been implicated in extracellular matrix regulation in the trabecular meshwork (TM) and ocular hypertension in mice. We investigated TLR4 expression in nor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415b2f2564098a653b11aa2fe36717a8
https://europepmc.org/articles/PMC7175615/
https://europepmc.org/articles/PMC7175615/
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 4; Pages: 1928
Although the extracellular matrix (ECM) in trabecular meshwork (TM) cells is known to be important in intraocular pressure (IOP) regulation, the molecular mechanisms involved in generating a glaucomatous environment in the TM are not completely under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d68e6a57d2bc56a0bc6579e1178d46
https://doi.org/10.3390/ijms23041928
https://doi.org/10.3390/ijms23041928
Autor:
Colleen M. McDowell, Krishnakumar Kizhatil, Michael H. Elliott, Darryl R. Overby, Joseph van Batenburg-Sherwood, J. Cameron Millar, Markus H. Kuehn, Gulab Zode, Ted S. Acott, Michael G. Anderson, Sanjoy K. Bhattacharya, Jacques A. Bertrand, Terete Borras, Diane E. Bovenkamp, Lin Cheng, John Danias, Michael Lucio De Ieso, Yiqin Du, Jennifer A. Faralli, Rudolf Fuchshofer, Preethi S. Ganapathy, Haiyan Gong, Samuel Herberg, Humberto Hernandez, Peter Humphries, Simon W. M. John, Paul L. Kaufman, Kate E. Keller, Mary J. Kelley, Ruth A. Kelly, David Krizaj, Ajay Kumar, Brian C. Leonard, Raquel L. Lieberman, Paloma Liton, Yutao Liu, Katy C. Liu, Navita N. Lopez, Weiming Mao, Timur Mavlyutov, Fiona McDonnell, Gillian J. McLellan, Philip Mzyk, Andrews Nartey, Louis R. Pasquale, Gaurang C. Patel, Padmanabhan P. Pattabiraman, Donna M. Peters, Vijaykrishna Raghunathan, Ponugoti Vasantha Rao, Naga Rayana, Urmimala Raychaudhuri, Ester Reina-Torres, Ruiyi Ren, Douglas Rhee, Uttio Roy Chowdhury, John R. Samples, E. Griffen Samples, Najam Sharif, Joel S. Schuman, Val C. Sheffield, Cooper H. Stevenson, Avinash Soundararajan, Preeti Subramanian, Chenna Kesavulu Sugali, Yang Sun, Carol B. Toris, Karen Y. Torrejon, Amir Vahabikashi, Janice A. Vranka, Ting Wang, Colin E. Willoughby, Chen Xin, Hongmin Yun, Hao F. Zhang, Michael P. Fautsch, Ernst R. Tamm, Abbot F. Clark, C. Ross Ethier, W. Daniel Stamer
Publikováno v:
Investigative ophthalmology & visual science, vol 63, iss 2
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2366dca55a396f9cef10de74cc76d5
https://doi.org/10.1167/iovs.63.2.12
https://doi.org/10.1167/iovs.63.2.12