Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Colleen M. Garvey"'
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 8, p e1005077 (2016)
Experimental studies have shown that one key factor in driving the emergence of drug resistance in solid tumors is tumor hypoxia, which leads to the formation of localized environmental niches where drug-resistant cell populations can evolve and surv
Externí odkaz:
https://doaj.org/article/ef50b8c52ca3440e80a214f80408d638
Autor:
Anthony Jusuf, Oscar Chen, Shannon M. Mumenthaler, Alyssa Sanchez, Michael E Doche, Ren X. Sun, Colleen M. Garvey, Brent K. Larson, Roy Lau, Emma J. Fong, Heinz-Josef Lenz
Publikováno v:
Cancers
Cancers, Vol 12, Iss 1393, p 1393 (2020)
Volume 12
Issue 6
Cancers, Vol 12, Iss 1393, p 1393 (2020)
Volume 12
Issue 6
Targeted agents have improved the efficacy of chemotherapy for cancer patients, however, there remains a lack of understanding of how these therapies affect the unsuspecting bystanders of the stromal microenvironment. Cetuximab, a monoclonal antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a39cbdbd321139bf4963f1734d4b019
https://doi.org/10.3390/cancers12061393
https://doi.org/10.3390/cancers12061393
Publikováno v:
Journal of Visualized Experiments : JoVE
Cellular processes are complex and result from the interplay between multiple cell types and their environment. Existing cell biology techniques often do not allow for accurate interpretation of this interplay. Using a quantitative imaging-based appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f2eafccdbea402f4104b77f258de6e
https://doi.org/10.3791/55844
https://doi.org/10.3791/55844
In this chapter we discuss, from an evolutionary perspective, the response of cancer cell populations to therapeutic intervention. There are many factors that influence therapeutic response. Here we focus on examples of cell-intrinsic and -extrinsic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d415ab047d376b868b5530704468a588
https://doi.org/10.1016/b978-0-12-804310-3.00010-7
https://doi.org/10.1016/b978-0-12-804310-3.00010-7
Autor:
Jerôme Abadie, Ole Ammerpohl, Audrey Arnal, Maureen Banach, Christa Beckmann, Florence Bernex, Amy M. Boddy, Joel S. Brown, Sam P. Brown, Francisco De Jesús Andino, James DeGregori, Eva-Stina Edholm, Pedro M. Enriquez-Navas, Paul W. Ewald, Dominique Faugère, Jasmine Foo, Déborah Garcia, Colleen M. Garvey, Robert A. Gatenby, Cindy Gidoin, Robert J. Gillies, Christoph Grunau, Valerie K. Harris, Kirsten Hattermann, Janka Held-Feindt, Henry H. Heng, Arig Ibrahim-Hashim, Irina Kareva, Hanna Kokko, Sophie Labrut, Karin Lemberger, Danika Lindsay, Mark C. Lloyd, Anders Pape Møller, Thomas Madsen, Andriy Marusyk, John F. McDonald, Shannon M. Mumenthaler, Aurora M. Nedelcu, Randolph M. Nesse, Leonard Nunney, Andrew F. Read, Kun Hyoe Rhoo, Christoph Röcken, Jacques Robert, Benjamin Roche, Shonagh Russell, Heiner Schäfer, Christian Schem, Denis Schewe, Joshua D. Schiffman, Susanne Schindler, Hinrich Schulenburg, Susanne Sebens, Kathleen Sprouffske, Holly A. Swain Ewald, Michael Synowitz, Aurélie Tasiemski, Frédéric Thomas, Sanjay Tiwari, Arne Traulsen, Anna Trauzold, Beata Ujvari, Thomas Valerius, Mark Vincent, Marion Vittecoq, Kristofer Wollein Waldetoft, Daniela Wesch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aae2ffaaab6c0cd07701758647444960
https://doi.org/10.1016/b978-0-12-804310-3.00027-2
https://doi.org/10.1016/b978-0-12-804310-3.00027-2
Publikováno v:
Cancer Research. 77:5908-5908
Drug resistance remains a major problem in the treatment of most cancers. For example, KRAS wild-type colorectal cancers (CRCs) are typically treated with the anti-epidermal growth factor receptor (EGFR) therapy cetuximab in combination with standard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa39f1481fe00e014f238f9484f88213
https://doi.org/10.1158/1538-7445.am2017-5908
https://doi.org/10.1158/1538-7445.am2017-5908
Publikováno v:
Cancer Research. 77:B13-B13
Cancer-associated fibroblasts (CAFs) are an important component of the tumor microenvironment known to influence various aspects of tumor progression, including response to therapy. However, this stromal cell subtype is extremely heterogeneous, both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fcefec16da7657f8d1dc2fc1840e86c
https://doi.org/10.1158/1538-7445.epso16-b13
https://doi.org/10.1158/1538-7445.epso16-b13
Autor:
Jasmine Foo, Danika Lindsay, Erin Spiller, Parag Mallick, David B. Agus, Colleen M. Garvey, Nathan C. Choi, Chun-Te Chiang, Shannon M. Mumenthaler
Publikováno v:
Scientific Reports
Tumor progression results from a complex interplay between cellular heterogeneity, treatment response, microenvironment and heterocellular interactions. Existing approaches to characterize this interplay suffer from an inability to distinguish betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e06fd50b1e46c94316ee76f339c10a
Publikováno v:
Cancer Research. 76:C39-C39
Tumor populations are in constant flux as a result of dynamic pressures of their surrounding microenvironment. Measuring the phenotypic response of multiple cell types exposed to physiological relevant tumor conditions has been a challenge due to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::465dc002cc3774f4055045cf120a9a0d
https://doi.org/10.1158/1538-7445.tme16-c39
https://doi.org/10.1158/1538-7445.tme16-c39
Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines.