Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Colleen M. Doshna"'
Autor:
Jim Finley, Lindsay Tomlinson, Sarah P. Nicholson, Stacey R. Oppenheimer, Jessica L. Moore, Maik Schuler, Nathan Heath Patterson, Kevin Beaumont, Brett D. Hollingshead, Zaher A. Radi, Colleen M. Doshna, Casey Ritenour, Richard M. Caprioli, Shawn P. O'Neil, Jon C. Cook, Jason Barricklow, Amanda King-Ahmad, Saurabh G. Vispute, Jeremy L. Norris
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 123
Systemic toxicity assessments for oral or parenteral drugs often utilize the concentration of drug in plasma to enable safety margin calculations for human risk assessment. For topical drugs, there is no standard method for measuring drug concentrati
Autor:
Michael D. Aleo, Colleen M. Doshna, Daniel Baltrukonis, Jay H. Fortner, Cynthia A. Drupa, Kimberly A. Navetta, Carol A. Fritz, David M. Potter, Maria E. Verdugo, William P. Beierschmitt
Publikováno v:
Journal of Applied Toxicology. 39
Autor:
Maria E. Verdugo, Cynthia A. Drupa, Kimberly A. Navetta, Daniel Baltrukonis, David M. Potter, William P. Beierschmitt, Colleen M. Doshna, Michael D. Aleo, Jay H. Fortner, Carol A. Fritz
Publikováno v:
Journal of applied toxicology : JATREFERENCES. 39(9)
CJ-12,918, a 5-lipoxygenase (5-LO) inhibitor, caused cataracts during a 1-month safety assessment studies in rats whereas the structurally similar ZD-2138 was without effect. For CJ-12,918 analogs, blocking different sites of metabolic liability redu
Autor:
James E. Finley, Germaine Boucher, Thomas A. Lanz, Julie Harney, Colleen M. Doshna, Anna K. Kopec, Petra H. Koza-Taylor, Karissa Adkins, Piyush Bajaj, Christopher Somps, Christopher Houle
Publikováno v:
Toxicology in Vitro. 70:105012
Alveolar type II (ATII) epithelial cells contain lamellar bodies (LBs) which synthesize and store lung surfactants. In animals, the inhibition or knockout of leucine-rich repeat kinase 2 (LRRK2) causes abnormal enlargement of LBs in ATII cells. This
Publikováno v:
Toxicology and Applied Pharmacology. 230:126-134
Renal-derived cysteinyl leukotrienes (cysLT), such as leukotrienes C{sub 4} (LTC{sub 4}) and D{sub 4} (LTD{sub 4}) are thought to mediate acute and chronic cyclosporine A (CSA) nephrotoxicity. However, whole-body cysLT elimination is regulated primar
1,2-naphthoquinone stimulates lipid peroxidation and cholesterol domain formation in model membranes
Publikováno v:
Investigative ophthalmologyvisual science. 54(12)
PURPOSE Naphthalene induces cataract formation through the accumulation of its reactive metabolite, 1,2-naphthoquinone (1,2-NQ), in the ocular lens. 1,2-NQ increases lens protein oxidation and disrupts fiber cell membrane function; however, the assoc
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 312(3)
The cataractogenic potential of the thiazolidinedione ciglitazone (CIG) was investigated in vivo and in vitro. In the rat, CIG caused a dose-dependent (30-300 mg/kg/day) increase in incidence and severity of nuclear cataract formation during a 3-mont