Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Colleen M, Lau"'
Autor:
Rui Li, Cristian Camilo Galindo, Dominique Davidson, Huaijian Guo, Ming-Chao Zhong, Jin Qian, Bin Li, Zsolt Ruzsics, Colleen M. Lau, Timothy E. O'Sullivan, Silvia M. Vidal, Joseph C. Sun, André Veillette
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113800- (2024)
Summary: Infection of mice by mouse cytomegalovirus (MCMV) triggers activation and expansion of Ly49H+ natural killer (NK) cells, which are virus specific and considered to be “adaptive” or “memory” NK cells. Here, we find that signaling lymp
Externí odkaz:
https://doaj.org/article/adb6c93e5f704d00b240fb56f26c9322
Autor:
Gabriela M. Wiedemann, Simon Grassmann, Colleen M. Lau, Moritz Rapp, Alejandro V. Villarino, Christin Friedrich, Georg Gasteiger, John J. O’Shea, Joseph C. Sun
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108498- (2020)
Summary: Natural killer (NK) cells are innate lymphocytes with the capacity to elicit adaptive features, including clonal expansion and immunological memory. Because signal transducer and activator of transcription 5 (STAT5) is essential for NK cell
Externí odkaz:
https://doaj.org/article/cd2ef75af09d4bb1bf1ac555481e0d9d
Autor:
Javiera Villar, Adeline Cros, Alba De Juan, Lamine Alaoui, Pierre-Emmanuel Bonte, Colleen M. Lau, Ioanna Tiniakou, Boris Reizis, Elodie Segura
Publikováno v:
Nature Immunology
Nature Immunology, 2023, 24 (1), pp.84-95. ⟨10.1038/s41590-022-01374-0⟩
Nature Immunology, 2023, 24 (1), pp.84-95. ⟨10.1038/s41590-022-01374-0⟩
In inflamed tissues, monocytes differentiate into macrophages (mo-Macs) or dendritic cells (mo-DCs). In chronic nonresolving inflammation, mo-DCs are major drivers of pathogenic events. Manipulating monocyte differentiation would therefore be an attr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96a5d825e90775521c76dc879423b46
https://doi.org/10.1038/s41590-022-01374-0
https://doi.org/10.1038/s41590-022-01374-0
Autor:
Wei-Feng Yen, Rahul Sharma, Montserrat Cols, Colleen M. Lau, Ashutosh Chaudhry, Priyanka Chowdhury, William T. Yewdell, Bharat Vaidyanathan, Amy Sun, Maryaline Coffre, Joseph N. Pucella, Chun-Chin Chen, Maria Jasin, Joseph C. Sun, Alexander Y. Rudensky, Sergei B. Koralov, Jayanta Chaudhuri
Publikováno v:
Cell Reports, Vol 27, Iss 5, Pp 1472-1486.e5 (2019)
Summary: The immunoglobulin heavy chain (Igh) locus features a dynamic chromatin landscape to promote class switch recombination (CSR), yet the mechanisms that regulate this landscape remain poorly understood. CHD4, a component of the chromatin remod
Externí odkaz:
https://doaj.org/article/ed2f3bea71bc4f469ef90f6397a16508
Publikováno v:
bioRxiv
Immune cells responding to pathogens undergo molecular changes that are intimately linked to genome organization. Recent work has demonstrated that natural killer (NK) and CD8+T cells experience substantial transcriptomic and epigenetic rewiring duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9be4f6f75cd875f2c6c545a2f288e1b
https://doi.org/10.1101/2023.01.16.524322
https://doi.org/10.1101/2023.01.16.524322
Autor:
Katharine C. Hsu, Peter M Conaty, Colleen M. Lau, Joseph C. Sun, Thomas Mertens, Ann B. Hill, Kerstin Laib Sampaio, M. Kazim Panjwani, Stuart P. Adler, Nai-Kong V. Cheung, Zeguang Wu, Rosa Sottile, Katja Srpan, Juliet N. Barker, Jean-Benoît Le Luduec
Publikováno v:
The Journal of Immunology. 207:2534-2544
Human CMV (HCMV) is a ubiquitous pathogen that indelibly shapes the NK cell repertoire. Using transcriptomic, epigenomic, and proteomic approaches to evaluate peripheral blood NK cells from healthy human volunteers, we find that prior HCMV infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35f2252fe439db89b51627fe509cd82e
https://doi.org/10.4049/jimmunol.2001319
https://doi.org/10.4049/jimmunol.2001319
Autor:
Stuart P. Weisberg, Matthew R. Smith-Raska, Jose M. Esquilin, Ji Zhang, Teresita L. Arenzana, Colleen M. Lau, Michael Churchill, Haiyan Pan, Apostolos Klinakis, Jack E. Dixon, Leonid A. Mirny, Siddhartha Mukherjee, Boris Reizis
Publikováno v:
Cell Reports, Vol 6, Iss 3, Pp 528-540 (2014)
Tumor-propagating cells in acute leukemia maintain a stem/progenitor-like immature phenotype and proliferative capacity. Acute myeloid leukemia (AML) and acute T-lymphoblastic leukemia (T-ALL) originate from different lineages through distinct oncoge
Externí odkaz:
https://doaj.org/article/3573c6cc24d94edc9d0325459f777a08
Autor:
Endi K. Santosa, Simon Grassmann, Sam Sheppard, Gabriela M. Wiedemann, Colleen M. Lau, Jean-Benoît Le Luduec, Joseph C. Sun, Katharine C. Hsu, Nicholas M. Adams, Celeste Dang
Publikováno v:
Nat Immunol
Cytokine signaling via signal transducer and activator of transcription (STAT) proteins is crucial for optimal antiviral responses of natural killer (NK) cells. However, the pleiotropic effects of both cytokine and STAT signaling preclude the ability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f53a7848682389589a99276a3ae296
https://doi.org/10.1038/s41590-021-00909-1
https://doi.org/10.1038/s41590-021-00909-1
Autor:
Iona S. Schuster, Xavier Y.X. Sng, Colleen M. Lau, David R. Powell, Orr-El Weizman, Peter Fleming, Georgia E.G. Neate, Valentina Voigt, Sam Sheppard, Andreas I. Maraskovsky, Sheridan Daly, Motoko Koyama, Geoffrey R. Hill, Stephen J. Turner, Timothy E. O’Sullivan, Joseph C. Sun, Christopher E. Andoniou, Mariapia A. Degli-Esposti
Publikováno v:
Immunity. 56:531-546.e6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19519a48b78e26c5d059d91273751dbf
https://doi.org/10.1016/j.immuni.2023.01.016
https://doi.org/10.1016/j.immuni.2023.01.016
Autor:
Ioanna Tiniakou, Pei-Feng Hsu, Lorena S. Lopez-Zepeda, Colleen M. Lau, Chetna Soni, Eduardo Esteva, Nicholas M. Adams, Fan Liu, Alireza Khodadadi-Jamayran, Tori C. Rodrick, Drew Jones, Aristotelis Tsirigos, Uwe Ohler, Mark T. Bedford, Stephen D. Nimer, Boris Reizis
SummaryDendritic cells (DCs) are immune sentinel cells that comprise antigen-presenting conventional DCs (cDCs) and cytokine-producing plasmacytoid DCs (pDCs). Cytokine Flt3 ligand (Flt3L) supports the proliferation of hematopoietic progenitors, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d54502faa257f498110d4ce7e273bd4
https://doi.org/10.1101/2022.05.11.491577
https://doi.org/10.1101/2022.05.11.491577